Photofrin ® photodynamic therapy with intratumor photosensitizer injection provides similar tumor response while reducing systemic skin photosensitivity: Pilot murine study

2017 ◽  
Vol 50 (5) ◽  
pp. 476-482 ◽  
Author(s):  
Timothy M. Baran
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Response ◽  
Skin Photosensitivity

scholarly journals Photodynamic Therapy of Lung Cancer With Bronchial Artery Infusion of Photofrin

1996 ◽  
Vol 2 (4) ◽  
pp. 203-206 ◽  
Author(s):  
Tetsuya Okunaka ◽  
Harubumi Kato ◽  
Chimori Konaka ◽  
Kinya Furukawa ◽  
Masahiko Harada ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Photodynamic Therapy ◽  
Early Stage ◽  
Bronchial Artery ◽  
Arterial Infusion ◽  
Early Stage Lung Cancer ◽  
Hospitalization Period ◽  
Bronchial Arterial Infusion ◽  
Skin Photosensitivity ◽  
Stage Lung Cancer

Photodynamic therapy (PDT) utilizing Photofrin is proving to be effective for the treatment of early stage lung cancer. However, wider clinical applications of Photofrin as a photosensitizer for various cancers are hampered by potentially serious and prolonged skin photosensitivity. To prevent these side effects and reduce the hospitalization period, we recently gave reduced doses of Photofrin by bronchial arterial infusion. Five patients with endoscopically evaluated minimally invasive carcinoma of the lung were given 0.7 mg/kg of Photofrin by bronchial arterial infusion 48 hr before PDT. Complete remission was obtained in all 5 cases and no case showed skin photosensitivity when exposed to sunlight under careful surveillance at one week after PDT.

Differential vascular response and relationship to tumor response with photodynamic therapy using WST-09 (TOOKAD)

2004 ◽  
Author(s):  
Greta M. Garbo ◽  
Peter K. Kik ◽  
Linda T. Harrison ◽  
Pierre H. Brun ◽  
Dominique Blanc ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Response ◽  
Vascular Response

Phase I and Pharmacokinetic Study of Photodynamic Therapy for High-Grade Gliomas Using a Novel Boronated Porphyrin

2001 ◽  
Vol 19 (2) ◽  
pp. 519-524 ◽  
Author(s):  
Mark A. Rosenthal ◽  
Bhadu Kavar ◽  
John S. Hill ◽  
Denis J. Morgan ◽  
Roger L. Nation ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Recommended Dose ◽  
Pharmacokinetic Parameters ◽  
Toxicity Profile ◽  
Intracranial Tumors ◽  
Time Curve ◽  
Concentration Time ◽  
Nonhematologic Toxicity ◽  
Dose Limiting Toxicity ◽  
Skin Photosensitivity

PURPOSE: To determine the recommended dose, toxicity profile, and pharmacokinetics of a novel boronated porphyrin (BOPP) for photodynamic therapy (PDT) of intracranial tumors. PATIENTS AND METHODS: BOPP was administered alone in increasing doses (0.25, 0.5, 1.0, 2.0, 4.0, or 8.0 mg/kg) preoperatively in patients with intracranial tumors undergoing postresection PDT until dose-limiting toxicity (DLT) was observed. RESULTS: Twenty-nine assessable patients with intracranial tumors received BOPP intravenously 24 hours before surgery. The recommended dose was 4 mg/kg. Dose escalation was limited by thrombocytopenia. The most common nonhematologic toxicity was skin photosensitivity. Pharmacokinetic parameters showed increased area under the plasma concentration-time curve and maximum concentration with increased dose. Tumor BOPP concentrations also increased with increased dose. CONCLUSION: BOPP at a dose of 4 mg/kg was well tolerated. DLT was thrombocytopenia, and photosensitivity was the only other toxicity of note. The efficacy of PDT using BOPP requires further exploration.

THE EFFECTS OF THROMBOXANE INHIBITORS ON THE MICROVASCULAR AND TUMOR RESPONSE TO PHOTODYNAMIC THERAPY

1993 ◽  
Vol 58 (3) ◽  
pp. 393-399 ◽  
Author(s):  
Victor H. Fingar ◽  
Kimberly A. Siegel ◽  
T. Jeffery Wieman ◽  
Karola Weber Doak
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Response

scholarly journals Effectiveness of Photodynamic Therapy and Nd-YAG Laser Treatment for Obstructed Tracheobronchial Malignancies

1999 ◽  
Vol 5 (3) ◽  
pp. 161-166 ◽  
Author(s):  
Kinya Furukawa ◽  
Tetsuya Okunaka ◽  
Hideki Yamamoto ◽  
Takaaki Tsuchida ◽  
Jitsuo Usuda ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Laser Treatment ◽  
Tumor Response ◽  
Careful Consideration ◽  
Alternative Therapies ◽  
Yag Laser ◽  
Segmental Bronchus ◽  
Laser Group ◽  
Tokyo Medical ◽  
Medical University

Since 1980, advanced lung carcinomas were treated with palliative laser therapy for the purpose of opening the endobronchial stenosis and obstruction by either photodynamic therapy (PDT) or Nd-YAG laser treatment at Tokyo Medical University. A total of 258 lesions were treated, 81 by PDT and 177 by Nd-YAG laser treatment. PDT achieved effective results in 61 (75%) of 81 lesions. In the Nd-YAG laser group, 143 (81%) of 177 lesions showed effective results. When the tumor was located in the trachea or main bronchi, effective results were obtained in 73% (19 of 26) of cases treated by PDT and in 93% of cases (64 of 69) treated by Nd-YAG laser. However, in cases in which the tumor was located in lobar or segmental bronchi, the tumor response was effective in 76% (42 of 55) of PDT-treated patients and 73% (79 of 108) of Nd-YAG laser-treated patients. With a mortality rate of 0%, the greatest advantage of PDT over Nd-YAG treatment was safety. Considering complications, PDT seems to be useful for obstruction of lobar and segmental bronchus. Nevertheless, when deciding among alternative therapies, physicians treating patients with advanced lung carcinoma should give careful consideration to the benefit and complications of both laser therapies and decide the most suitable modality.

scholarly journals Measurement of Cyanine Dye Photobleaching in Photosensitizer Cyanine Dye Conjugates Could Help in Optimizing Light Dosimetry for Improved Photodynamic Therapy of Cancer

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 1842 ◽  
Author(s):  
Nadine James ◽  
Ravindra Cheruku ◽  
Joseph Missert ◽  
Ulas Sunar ◽  
Ravindra Pandey
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Tumor Response ◽  
Cyanine Dye ◽  
Fluence Rate ◽  
Low Light ◽  
Light Dosimetry ◽  
Light Fluence ◽  
Photodynamic Therapy Of Cancer

Photodynamic therapy (PDT) of cancer is dependent on three primary components: photosensitizer (PS), light and oxygen. Because these components are interdependent and vary during the dynamic process of PDT, assessing PDT efficacy may not be trivial. Therefore, it has become necessary to develop pre-treatment planning, on-line monitoring and dosimetry strategies during PDT, which become more critical for two or more chromophore systems, for example, PS-CD (Photosensitizer-Cyanine dye) conjugates developed in our laboratory for fluorescence-imaging and PDT of cancer. In this study, we observed a significant impact of variable light dosimetry; (i) high light fluence and fluence rate (light dose: 135 J/cm2, fluence rate: 75 mW/cm2) and (ii) low light fluence and fluence rate (128 J/cm2 and 14 mW/cm2 and 128 J/cm2 and 7 mW/cm2) in photobleaching of the individual chromophores of PS-CD conjugates and their long-term tumor response. The fluorescence at the near-infrared (NIR) region of the PS-NIR fluorophore conjugate was assessed intermittently via fluorescence imaging. The loss of fluorescence, photobleaching, caused by singlet oxygen from the PS was mapped continuously during PDT. The tumor responses (BALB/c mice bearing Colon26 tumors) were assessed after PDT by measuring tumor sizes daily. Our results showed distinctive photobleaching kinetics rates between the PS and CD. Interestingly, compared to higher light fluence, the tumors exposed at low light fluence showed reduced photobleaching and enhanced long-term PDT efficacy. The presence of NIR fluorophore in PS-CD conjugates provides an opportunity of fluorescence imaging and monitoring the photobleaching rate of the CD moiety for large and deeply seated tumors and assessing PDT tumor response in real-time.

scholarly journals Quantitative Multi-Parametric Magnetic Resonance Imaging of Tumor Response to Photodynamic Therapy

PLoS ONE ◽  
2016 ◽  
Vol 11 (11) ◽  
pp. e0165759 ◽  
Author(s):  
Tom J. L. Schreurs ◽  
Stefanie J. Hectors ◽  
Igor Jacobs ◽  
Holger Grüll ◽  
Klaas Nicolay ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Photodynamic Therapy ◽  
Magnetic Resonance ◽  
Tumor Response ◽  
Resonance Imaging

Monitoring Tumor Response During Photodynamic Therapy Using Near-infrared Photon-migration Spectroscopy¶

2007 ◽  
Vol 73 (6) ◽  
pp. 669-677 ◽  
Author(s):  
Tuan H. Pham ◽  
René Hornung ◽  
Michael W. Berns ◽  
Yona Tadir ◽  
Bruce J. Tromberg
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Tumor Response ◽  
Photon Migration ◽  
Infrared Photon
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