scholarly journals Eye Drops, Powder and Solvent for Suspension Dosage Form

2020 ◽  
Author(s):  
Keyword(s):  
Dosage Form ◽  
Eye Drops

scholarly journals Clinical Application and Efficacy of Silver Drug in Ophthalmology: A Literature Review and New Formulation of EYE Drops with Drug Silver (I) Complex of Metronidazole with Improved Dosage Form

Biomedicines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 210
Author(s):  
Arleta Waszczykowska ◽  
Dominik Żyro ◽  
Justyn Ochocki ◽  
Piotr Jurowski
Keyword(s):  
Dosage Form ◽  
Complex Analysis ◽  
Bacterial Resistance ◽  
Eye Drops ◽  
Ophthalmic Diseases ◽  
The Stability ◽  
New Formulation ◽  
Additional Therapy ◽  
Antibacterial Potential

The use of silver preparations in medicine is becoming increasingly popular. The basic aim of this evaluation was to review the literature on the clinical (in vivo) and antibacterial potential of silver preparations in ophthalmic diseases. The second goal was to summarize the results of experimental research on the use of silver preparations in ophthalmology. The third objective was to present a method for stabilizing eye drops containing silver (I) complex. Analysis of the pH stability of the silver (I) complex with metronidazole in the prepared dosage form (eye drops) was carried out. Most silver preparations are clinically used for topical application. Few experimental results indicate the usefulness of intraocular or systemic administration of silver (I) preparations as an alternative or additional therapy in infectious and angiogenic eye diseases. The development of a new formulation increases the stability of the dosage form. New forms of silver (I) products will certainly find application in the treatment of many ophthalmic diseases. One of the most important features of the silver (I) complex is its capacity to break down bacterial resistance. The new eye drops formula can significantly improve comfort of use. Due to their chemical nature, silver (I) compounds are difficult to stabilize, especially in the finished dosage form.

Benzyldimethyl[3-(miristoylamino)-propyl]ammonium chloride stabilized silver nanoparticles (Argumistin™) in medicine: results of clinical trials for treatment of infectious diseases of dogs and perspectives for humans

2016 ◽  
Vol 8 (4) ◽  
Author(s):  
Yurii Krutyakov ◽  
Alexey Klimov ◽  
Boris Violin ◽  
Vladimir Kuzmin ◽  
Victoria Ryzhikh ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Clinical Trials ◽  
Infectious Diseases ◽  
Ammonium Chloride ◽  
Dosage Form ◽  
Multiple Drug Resistance ◽  
Periodontal Diseases ◽  
Veterinary Drug ◽  
Antibacterial Drug ◽  
Eye Drops

AbstractIncreased interest in nanosilver during the last 10 years is mainly explained by the emergence and spread of pathogenic microorganisms with multiple drug resistance, including resistance to last-generation antibiotics. In this article, we for the first time, give a description of large-scale clinical trials of a new nanosilver based antibacterial drug [containing two active components: silver nanoparticles (AgNPs) (10–50 ppm) and benzyldimethyl[3-(miristoylamino)-propyl]ammonium chloride (100 ppm)] registered in Russia in 2015 as a veterinary drug under the brand name Argumistin™. This drug has been approved for application in a diluted dosage form – as eye drops, intranasal drops and orally; it has also been approved for application in a more concentrated dosage form (up to 50 ppm of nanosilver) as ear drops and as an antiseptic during demodicosis and gum disease treatment, open wound treatment, etc. We have registered the high therapeutic effectiveness of Argumistin™ during treatment of infectious conjunctivitis, gingivitis, parodontosis and enteritis of dogs. Application of this antibacterial drug gives considerable (up to 70% in case of periodontal diseases) reduction in the treatment period and prevention of complications. The results of clinical trials in the treatment of infectious diseases of dogs makes Argumistin™ a promising candidate for an effective antibacterial drug for human medicine.

scholarly journals Elaboration of the bischofite eye drops using the biopharmaceutical criteria

2011 ◽  
Vol 10 (5) ◽  
pp. 162-166
Author(s):  
B. B. Sysuev ◽  
Ye. B. Sysuev ◽  
I. Yu. Mitrofanova
Keyword(s):  
Analytic Hierarchy Process ◽  
Magnesium Chloride ◽  
Dosage Form ◽  
Practical Importance ◽  
Eye Drops ◽  
Mineral Component ◽  
Analytic Hierarchy ◽  
Pharmaceutical Form ◽  
Hierarchy Process

Our research is of theoretical and practical importance and aims at the development of ophthalmological dosage form comprising mineral component (bischofite). It is mineral complex consisting of 96% magnesium chloride with macro- and microelements. Having carried out complex physicochemical and biopharmaceutical researches in vitro, we developed composition and technology of 10% bischofite solution in the form of eye drops. After is one of the perspective tools in technological researches. After using of the analytic hierarchy process by T. Saaty the optimal eye drops composition was selected according to all chosen criteria for this pharmaceutical form.

Antibacterial Effectiveness of Chloramphenicol Ophthalmic Hydrogel Against Staphylococcus aureus ATCC 25923 and Bacillus subtilis ATCC 6633

2018 ◽  
Vol 9 (3) ◽  
Author(s):  
Kurniawansyah I S ◽  
Sulistiyaningsih . ◽  
Maulia M G ◽  
Budiman A
Keyword(s):  
Antibacterial Activity ◽  
Dosage Form ◽  
Large Fraction ◽  
Three Dimensional ◽  
Polymeric Materials ◽  
Good Alternative ◽  
Eye Drops ◽  
Significant Difference ◽  
Bacillus Subtilis Atcc ◽  
Physical Preparation

Background: Hydrogels are the unique three-dimensional polymeric materials that can hold a large fraction of water thus aims to release the drug in a controlled manner. Controlled drug delivery systems that are meant to deliver the drugs at predetermined rate for a pre-programmed period is a good alternative to accomplish and overcome the inadequacy of low bioavailability of conventional dosage form. Aims and Objectives: To determine the effectiveness of antibacterial activity of chloramphenicol in ophthalmic hydrogel preparations against S. aureus and B. subtilis comparing with eye drops dosage form. Materials and Methods: Ophthalmic hydrogel and eye drops of chloramphenicol were used for comparing the effectiveness of antibacterial activity against S. aureus and B. subtillis using agar diffusion methods with perforation technique. The observations were made for 28 days with evaluation of the physical preparation includes organoleptic, pH, viscosity. Result: The chloramphenicol eye drops preparation showed that the largest inhibition diameter at concentrations 20%,10% and 5% were 2.87-2.90; 2.64-2.76 and 2.48-2.55 cm. During comparison with opthalmic hyrdogel preparations there was not a very significant difference observed at opthalmic hydrogel preparation of 20% , 10% and 5% inhibition diameter obtained were 2.85-2.98; 2.58-2.69 and 2.42-2.46 cm. This showed that both preparations were equally effective in inhibition of S. aureus and B. subtilis growth. The minimum inhibitory concentration growth of the hydrogel opthalmic preparations against the bacteria B. subtilis was 10% and S. aureus at concentration 20%. In the evaluation of the physical preparation includes organoleptic, pH, viscosity showed good results, and still within the range of requirements. Conclusion: The effectiveness of antibacterial preparations in chloramphenicol ophthalmic hydrogel were not much of a difference compared to the form of eye drops preparations against S. aureus and B. subtilis.

scholarly journals Scientific substantiation of the concentration of excipients for the manufacture of eye drops Angiolin

2021 ◽  
Vol 14 (1) ◽  
pp. 52-55
Author(s):  
L. I. Kucherenko ◽  
I. A. Mazur ◽  
R. R. Akopian ◽  
O. O. Portna ◽  
H. I. Tkachenko
Keyword(s):  
Sodium Chloride ◽  
Dosage Form ◽  
Pharmaceutical Chemistry ◽  
Eye Drops ◽  
Technological Parameters ◽  
Three Solutions ◽  
High Molecular Weight Complex ◽  
Scientific Substantiation ◽  
Medical University

Throughout human history, cataracts have been one of the leading causes of blindness. For this disease, we studied the market of drugs of domestic and foreign production. The object of our study was the subgroup S10X Other ophthalmic drugs. Employees of the Department of Pharmaceutical Chemistry of Zaporizhzhia State Medical University (ZSMU) together with specialists of the NGO “Pharmatron” was synthesized a new compound, which was named Angiolin. A rational dosage form in the form of eye drops was proposed for the new drug. Since the drops continue to be the most common and widely used in practice dosage form. We have previously selected the optimal content of the active substance in eye drops. As is known from the technological parameters, eye drops must be isotonic, ie in their composition should be added excipients. The aim of our work is to select the concentration of excipients for the manufacture of eye drops Angiolin. Materials and methods. During the work at the Department of Pharmaceutical Chemistry of ZSMU, three solutions of eye drops Angiolin with different composition were prepared, and later the theoretical osmolarity was calculated. Results. Accurate theoretical calculation of the osmolarity of solutions containing substances with high molecular weight, complex total extracts, and highly concentrated solutions is impossible. Since the excipient was used methylcellulose, it was better to perform such a calculation experimentally, through the determination of osmolality. On the basis of the conducted researches, for correction of osmolarity, we were chosen – sodium chloride. Sodium chloride was selected at a concentration of 7.0 g/l, which creates an osmolality of the drug equal to 234.3 mosmol/kg. The estimated value at the same concentration of sodium chloride was 239.56 mosmol/l. The value of osmolarity of eye drops was calculated from it makes 302,18 mosmol/l that was confirmed the correctness of the chosen concentration of sodium chloride as a part of eye drops. Conclusions. Based on the above, we selected the concentration of excipients for the manufacture of eye drops Angiolin.

scholarly journals A prospective study of drug utilization in patients attending ophthalmology outpatient department at KBN teaching and general hospital of Gulbarga, India

2018 ◽  
Vol 7 (8) ◽  
pp. 1512
Author(s):  
Md Mohsin Ahmed ◽  
Amogh Harsoor ◽  
Sana Nizami
Keyword(s):  
Drug Use ◽  
Drug Utilization ◽  
Dosage Form ◽  
Antimicrobial Agents ◽  
Outpatient Department ◽  
Eye Drops ◽  
Duration Of Treatment ◽  
Rational Use ◽  
Duration Of Therapy ◽  
Generic Prescribing

Background: Drug utilization studies are an important part of rational use of drugs. Assessment of drug use pattern especially in developing countries is becoming increasingly necessary to promote the rational use of drugs. This study was planned to prospectively assess the drug utilization pattern in Ophthalmology outpatient department at KBN teaching and General hospital.Methods: After approval from Ethics Committee, the prescriptions of 1000 outpatients were analyzed using a predesigned form to record information from the OPD prescriptions. Mentioned WHO drug use indicators and additional indices were analyzed: Average number of drugs per prescription, number of encounters with antibiotics, percentage of encounters with injections, percentage of drugs prescribed by their generic names, percentage of drugs prescribed from the National Essential Drug List (NEDL), etc.Results: Prescription analysis showed that the average number of drugs per prescription was 2.6. The drugs were prescribed in the several forms, predominant dosage form been topical eye drops (69.58%) followed by tablets (11.98%), ointments (10.17%) and capsules (6.6%). The ‘dosage form’ was indicated for all of the drugs prescribed, the ‘frequency’ of drug administration was present in 96.5% of the drugs, and the duration of treatment for 82% of the drugs prescribed. Topical Antimicrobial agents were the most commonly prescribed drugs. followed by anti-inflammatory and anti-allergic, lubricants, anti-glaucoma drugs, etc. Percentage of drugs prescribed by generic name and from NEDL was 7.98% and 55 % respectively.Conclusions: The prescription writing errors were less, however, there was very low generic prescribing and inadequate information about the duration of therapy in many prescriptions. Generic prescribing can be improved. Duration of therapy should be mentioned in all prescriptions. It is essential that appropriate guidelines on the use of topical antimicrobials are required to ensure rational prescribing.

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