scholarly journals Islet Neogenesis Associated Protein Antibody Measurement

2020 ◽  
Author(s):  
Keyword(s):  
Islet Neogenesis

The Role of Islet Neogeneis-Associated Protein (INGAP) in Pancreatic Islet Neogenesis

2009 ◽  
Vol 10 (1) ◽  
pp. 37-45 ◽  
Author(s):  
Gary Pittenger ◽  
David Taylor-Fishwick ◽  
Aaron Vinik
Keyword(s):  
Pancreatic Islet ◽  
Islet Neogenesis

scholarly journals P35 El INGAP-PP estimula cambios a nivel transcripcional tanto en células endocrinas como no endocrinas del islote

2020 ◽  
Vol 54 (3Sup) ◽  
pp. 140
Author(s):  
Ana Carolina Heidenreich ◽  
Agustín Romero ◽  
Carolina Román ◽  
Bárbara Maiztegui ◽  
Luis Emilio Flores ◽  
...  
Keyword(s):  
Rna Seq ◽  
Islet Neogenesis ◽  
Diabetes Tipo 2

Introducción: el INGAP-PP, un pentadecapéptido derivado del INGAP (Islet Neogenesis Associated Protein), potencia la secreción de insulina frente al estímulo de glucosa, aumenta la masa de células ß insulares y las protege de la acción citotóxica de la estreptozotocina. Estas evidencias nos permiten proponerlo como un posible recurso terapéutico para la prediabetes y diabetes tipo 2.Objetivos: estudiar los mecanismos, a nivel transcriptómico, que condicionan los efectos del INGAP-PP destacando la contribución de distintos tipos celulares en su rol terapéutico.Materiales y métodos: se aislaron islotes de rata Wistar macho normales y se cultivaron 4 días en ausencia o presencia de INGAP-PP y glucosa 11 mM. Luego de comprobar el efecto potenciador del INGAP-PP sobre la secreción de insulina inducida por glucosa 16,7 mM, se extrajo ARN de los islotes de ambos grupos y se realizó una secuenciación masiva (RNA-seq).

scholarly journals On the dynamics of the human endocrine pancreas and potential consequences for the development of type 1 diabetes

2019 ◽  
Vol 57 (4) ◽  
pp. 503-511 ◽  
Author(s):  
Oskar Skog ◽  
Olle Korsgren
Keyword(s):  
Cell Proliferation ◽  
Type 1 Diabetes ◽  
Beta Cell ◽  
Endocrine Pancreas ◽  
Blood Perfusion ◽  
Beta Cell Proliferation ◽  
Vascular Events ◽  
Islet Neogenesis ◽  
Islet Mass

Abstract Little is known about the human islet life span, and beta-cell neogenesis is generally considered rare in adults. However, based on available data on beta-cell proliferation, calculations can be made suggesting that the dynamics of the endocrine pancreas is considerable even during adulthood, with islet neogenesis and a sustained increase in size of already formed islets. Islet-associated hemorrhages, frequently observed in most mammals including humans, could account for a considerable loss of islet parenchyma balancing the constant beta-cell proliferation. Notably, in subjects with type 1 diabetes, periductal accumulation of leukocytes and fibrosis is frequently observed, findings that are likely to negatively affect islet neogenesis from endocrine progenitor cells present in the periductal area. Impaired neogenesis would disrupt the balance, result in loss of islet mass, and eventually lead to beta-cell deficiency and compromised glucose metabolism, with increased islet workload and blood perfusion of remaining islets. These changes would impose initiation of a vicious circle further increasing the frequency of vascular events and hemorrhages within remaining islets until the patient eventually loses all beta-cells and becomes c-peptide negative.

Neurod/betacellulin gene therapy induces pancreatic islet neogenesis in the liver and reverses diabetes in mice

2003 ◽  
Vol 124 (4) ◽  
pp. A86
Author(s):  
Mineko Fujimiya ◽  
Hideto Kojima ◽  
Tamio Nakahara ◽  
Lawrence Chan
Keyword(s):  
Gene Therapy ◽  
Pancreatic Islet ◽  
Islet Neogenesis ◽  
Diabetes In Mice

NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice

10.1038/nm867 ◽  
2003 ◽  
Vol 9 (5) ◽  
pp. 596-603 ◽  
Author(s):  
Hideto Kojima ◽  
Mineko Fujimiya ◽  
Kazuhiro Matsumura ◽  
Patrick Younan ◽  
Hirotsugu Imaeda ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Islet Neogenesis ◽  
Diabetes In Mice

Liver carbohydrates metabolism: A new islet-neogenesis associated protein peptide (INGAP-PP) target

Peptides ◽  
2018 ◽  
Vol 101 ◽  
pp. 44-50
Author(s):  
Hernán Gonzalo Villagarcía ◽  
Carolina Lisi Román ◽  
María Cecilia Castro ◽  
Luisa Arbeláez González ◽  
María Teresa Ronco ◽  
...  
Keyword(s):  
Islet Neogenesis

scholarly journals A role for islet neogenesis in curing diabetes

Diabetologia ◽  
2009 ◽  
Vol 52 (5) ◽  
pp. 735-738 ◽  
Author(s):  
G. L. Pittenger ◽  
D. Taylor-Fishwick ◽  
A. I. Vinik
Keyword(s):  
Islet Neogenesis
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