scholarly journals Gain of Chromosome 1q21

2020 ◽  
Author(s):  
Keyword(s):  
Chromosome 1Q21

scholarly journals Characterization of the human extracellular matrix protein 1 gene on chromosome 1q21

1997 ◽  
Vol 16 (5) ◽  
pp. 289-292 ◽  
Author(s):  
Maureen R. Johnson ◽  
Douglas J. Wilkin ◽  
Hans L. Vos ◽  
Rosa Isela Ortiz De Luna ◽  
Anindya M. Dehejia ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Matrix Protein ◽  
Extracellular Matrix Protein ◽  
Extracellular Matrix Protein 1 ◽  
Chromosome 1Q21

Contribution of Chromosome 1q21-q23 to Familial Combined Hyperlipidemia in Mexican Families

2004 ◽  
Vol 68 (5) ◽  
pp. 419-427 ◽  
Author(s):  
A. Huertas-Vázquez ◽  
J. P. del Rincón ◽  
S. Canizales-Quinteros ◽  
L. Riba ◽  
G. Vega-Hernández ◽  
...  
Keyword(s):  
Familial Combined Hyperlipidemia ◽  
Mexican Families ◽  
Chromosome 1Q21

scholarly journals Chromosome 1q21 amplification and oncogenes in hepatocellular carcinoma

2010 ◽  
Vol 31 (9) ◽  
pp. 1165-1171 ◽  
Author(s):  
Leilei Chen ◽  
Tim Hon Man Chan ◽  
Xin-yuan Guan
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chromosome 1Q21

Genetic Analysis of the Epidermal Differentiation Complex (EDC) on Human Chromosome 1q21: Chromosomal Orientation, New Markers, and a 6-Mb YAC Contig

Genomics ◽  
1996 ◽  
Vol 37 (3) ◽  
pp. 295-302 ◽  
Author(s):  
Ingo Marenholz ◽  
Armin Volz ◽  
Andreas Ziegler ◽  
Angela Davies ◽  
Ioannis Ragoussis ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Human Chromosome ◽  
Epidermal Differentiation ◽  
Epidermal Differentiation Complex ◽  
Yac Contig ◽  
Chromosome 1Q21

scholarly journals Fine Mapping of the PSORS4 Psoriasis Susceptibility Region on Chromosome 1q21

2001 ◽  
Vol 116 (5) ◽  
pp. 728-730 ◽  
Author(s):  
Francesca Capon ◽  
Sabrina Semprini ◽  
Giuseppe Novelli ◽  
Sergio Chimenti ◽  
Giuseppe Fabrizi ◽  
...  
Keyword(s):  
Fine Mapping ◽  
Susceptibility Region ◽  
Chromosome 1Q21

scholarly journals Molecular Cloning of Translocation t(1;14)(q21;q32) Defines a Novel Gene (BCL9) at Chromosome 1q21

Blood ◽  
1998 ◽  
Vol 91 (6) ◽  
pp. 1873-1881 ◽  
Author(s):  
T.G. Willis ◽  
I.R. Zalcberg ◽  
L.J.A. Coignet ◽  
I. Wlodarska ◽  
M. Stul ◽  
...  
Keyword(s):  
Sequence Analysis ◽  
B Cell ◽  
Lymphoblastic Leukemia ◽  
Response To Therapy ◽  
Cdna Clones ◽  
Fish Analysis ◽  
Long Distance ◽  
B Cell Malignancies ◽  
Low Level ◽  
Chromosome 1Q21

Abstract Abnormalities of chromosome 1q21 are common in B-cell malignancies and have been associated with a poor response to therapy. The nature of the involved gene(s) on chromosome 1q21 remains unknown. A cell line (CEMO-1) has recently been established from a patient with precursor-B–cell acute lymphoblastic leukemia (ALL), which exhibited a t(1;14)(q21;q32). To identify the gene involved in this translocation, we have cloned both rearranged IGHJ alleles using long-distance inverse polymerase chain reaction (LDI-PCR). TwoIGHJ fragments were amplified from CEMO-1 DNA and sequenced. One allele showed novel sequences upstream of JH5 with no homology to either IGH or any other sequences on the databases. Using a single-copy Xho I fragment immediately 5′ ofJH5, PAC clones were isolated and mapped to chromosome 1q21 on normal metaphases by fluorescence in situ hybridization (FISH), confirming that this allele represented the t(1;14)(q21;q32) breakpoint. Sequence analysis of the 1q21 XhoI fragment showed identity with an expressed sequence tag (EST), and this probe was therefore used to probe Northern blots. Two transcripts of 6.3 kb and 4.2 kb expressed at low level in mRNA from all tissues were detected: a third transcript of 1.6 kb was expressed only in thymus, spleen, and small intestine. Full-lengthBCL9 cDNA clones were obtained from a normal human fetal brain cDNA library supplemented by 5′ and 3′ RACE. Sequence analysis predicted a protein of 1394 amino acids containing 18% proline, 11% glycine, 11% serine, and 6% methionine, but no recognizable protein motifs or significant homologies to any other known proteins. The CEMO-1 1q21 breakpoint fell within the 3′ UTR of the BCL9 gene. Low-level expression of BCL9 was detected in Epstein-Barr virus-transformed normal B cells by Northern blot; in contrast, abundant BCL9 expression was observed in CEMO-1, indicating that deregulated expression of this gene was one pathological consequence of the translocation. Screening of a panel of 39 B-cell malignancies with 1q abnormalities by Southern blot showed one additional case with a breakpoint in the 3′ UTR ofBCL9, indicating that this was a recurrent breakpoint. FISH analysis using an 850-kb YAC spanning BCL9 identified a further case with t(1;22)(q21;q11) causing juxtaposition of BCL9 to theIGλ locus. Other breakpoints were heterogeneous, falling both centromeric (10 cases) and telomeric (10 cases) of the BCL9gene. These data suggest that BCL9 may be the target of translocation in some B-cell malignancies with abnormalities of 1q21 and that deregulated BCL9 expression may be important in their pathogenesis.

Clinical Features of Five Pedigrees Genetically Linked to the Juvenile Glaucoma Locus on Chromosome 1q21-q31

Ophthalmology ◽  
1995 ◽  
Vol 102 (12) ◽  
pp. 1782-1789 ◽  
Author(s):  
Janey L. Wiggs ◽  
Elizabeth A. Del Bono ◽  
Joel S. Schuman ◽  
B. Thomas Hutchinson ◽  
David S. Walton
Keyword(s):  
Clinical Features ◽  
Juvenile Glaucoma ◽  
Chromosome 1Q21
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