scholarly journals AHSG Gene

2020 ◽  
Author(s):  
Keyword(s):  
Ahsg Gene

scholarly journals Genetic Variation of the Human α-2-Heremans-Schmid Glycoprotein (AHSG) Gene Associated with the Risk of SARS-CoV Infection

PLoS ONE ◽  
2011 ◽  
Vol 6 (8) ◽  
pp. e23730 ◽  
Author(s):  
Xiaohui Zhu ◽  
Yan Wang ◽  
Hongxing Zhang ◽  
Xuan Liu ◽  
Ting Chen ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Ahsg Gene

scholarly journals Improved Insulin Sensitivity and Resistance to Weight Gain in Mice Null for the Ahsg Gene

Diabetes ◽  
2002 ◽  
Vol 51 (8) ◽  
pp. 2450-2458 ◽  
Author(s):  
S. T. Mathews ◽  
G. P. Singh ◽  
M. Ranalletta ◽  
V. J. Cintron ◽  
X. Qiang ◽  
...  
Keyword(s):  
Weight Gain ◽  
Insulin Sensitivity ◽  
Insulin Sensitivity And Resistance ◽  
Ahsg Gene

Association of AHSG gene polymorphisms with serum Fetuin-A levels in individuals with cardiovascular calcification in west of Iran

2020 ◽  
Vol 47 (3) ◽  
pp. 1809-1820
Author(s):  
Ehsan Mohammadi-Noori ◽  
Nahid Salehi ◽  
Hadi Mozafari ◽  
Daniel Elieh Ali Komi ◽  
Mohammadrza Saidi ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Fetuin A ◽  
Ahsg Gene

scholarly journals Genetic Mapping and Functional Studies of a Natural Inhibitor of the Insulin Receptor Tyrosine Kinase: The Mouse Ortholog of Humanα2-HS Glycoprotein

2000 ◽  
Vol 1 (4) ◽  
pp. 249-263 ◽  
Author(s):  
Vivian J. Cintrón ◽  
Minoru S. H. Ko ◽  
Kenneth D. Chi ◽  
Jason P. Gross ◽  
Pothur R. Srinivas ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Insulin Receptor ◽  
Genomic Library ◽  
Sequence Data ◽  
Recombinant Baculovirus ◽  
Mus Spretus ◽  
Insulin Receptor Tyrosine Kinase ◽  
First Intron ◽  
Ahsg Gene

Fetuin/α2-HS glycoprotein (α2-HSG) homologs have been identified in several species including rat, sheep, pig, rabbit, guinea pig, cattle, mouse and human. Multiple physiological roles for these homologs have been suggested, including ability to bind to hydroxyapatite crystals and to specifically inhibit the tyrosine kinase (TK) activity of the insulin receptor (IR). In this study we report the identification, cloning, and characterization of the mouse Ahsg gene and its function as an IR-TK inhibitor. Genomic clones derived from a mouse Svj 129 genomic library were sequenced in order to characterize the intron–exon organization of the mouse Ahsg gene, including an 875 bp subclone containing 154 bp upstream from the transcription start site, the first exon, and part of the first intron. A second genomic subclone harboring a 3.45 kb Bgl II fragment contained exons 2, 3 and 4 in addition to two adjacent elements within the first intron-a repetitive element of the B1 family (92 bp) and a 271 bp tract of (T,C)n* (A,G)n. We have mapped mouse Ahsg at 16 cM adjacent to the Diacylglycerol kinase 3 (Dagk3) gene on chromosome 16 by genotyping interspecific backcross panels between C57BL/6J andMus spretus. The position is syntenic with human chromosome 3q27, where the human AHSG gene resides. Using recombinant mouseα2-HSG expressed from a recombinant baculovirus, we demonstrate that mouseα2-HSG inhibits insulin–stimulated IR autophosphorylation and IR-TKAin vitro. In addition, mouseα2-HSG (25μg/ml) completely abolishes insulin-induced DNA synthesis in H-35 rat hepatoma cells. Based on the sequence data and functional analysis, we conclude that the mouse Ahsg gene is the true ortholog of the human AHSG gene.

AHSG gene variant is associated with leanness among Swedish men

2005 ◽  
Vol 117 (1) ◽  
pp. 54-60 ◽  
Author(s):  
Catharina Lavebratt ◽  
Sofia Wahlqvist ◽  
Louise Nordfors ◽  
Johan Hoffstedt ◽  
Peter Arner
Keyword(s):  
Gene Variant ◽  
Ahsg Gene

AHSG gene polymorphisms are associated with bone mineral density in Caucasian nuclear families

2007 ◽  
Vol 22 (8) ◽  
pp. 527-532 ◽  
Author(s):  
Yan-Jun Yang ◽  
Yan-Bo Wang ◽  
Shu-Feng Lei ◽  
Ji-Rong Long ◽  
Hui Shen ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Gene Polymorphisms ◽  
Mineral Density ◽  
Nuclear Families ◽  
Ahsg Gene

scholarly journals Association of α2-Heremans-Schmid Glycoprotein Polymorphisms with Subclinical Atherosclerosis

2007 ◽  
Vol 92 (1) ◽  
pp. 345-352 ◽  
Author(s):  
Allison B. Lehtinen ◽  
Kathryn P. Burdon ◽  
Joshua P. Lewis ◽  
Carl D. Langefeld ◽  
Julie T. Ziegler ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Carotid Artery ◽  
Atherosclerotic Plaque ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Fetuin A ◽  
Media Thickness ◽  
European Americans ◽  
Calcified Plaque ◽  
Ahsg Gene

Abstract Context: Cardiovascular disease is significantly increased in individuals with type 2 diabetes mellitus (T2DM), especially in the presence of calcified atherosclerotic plaque. Fetuin A is an important mineralization inhibitor, and polymorphisms in the corresponding α2-Heremans-Schmid glycoprotein (AHSG) gene have been shown to be associated with serum fetuin A levels and free phosphate levels, as well as cardiovascular disease death. Objective: This study investigated whether polymorphisms in AHSG contribute to the development of calcified atherosclerotic plaque in the coronary and carotid arteries and to carotid artery intima-media thickness. Design: Eleven single nucleotide polymorphisms (SNPs) in AHSG were genotyped and evaluated for association with quantitative measures of subclinical atherosclerosis. Participants: Subjects were 829 T2DM-affected European Americans from 368 families in the Diabetes Heart Study. Main Outcome Measures: Participants were phenotyped for cardiovascular risk factors and atherosclerosis traits. The extent of coronary artery calcified plaque (CorCP) and carotid artery calcified plaque (CarCP) was measured using quantitative computed tomography, and carotid artery intima-media thickness was measured using high-resolution B mode ultrasonography. Results: Four SNPs in AHSG were nominally associated with CorCP in European Americans with T2DM (P < 0.05). Two 3-SNP haplotypes in the exon 6–7 region were associated with CorCP in European Americans with T2DM (P < 0.06). Conclusions: Sequence variants in the AHSG gene affect the extent of CorCP in T2DM-affected European Americans, consistent with the known biological role of AHSG in vascular calcification. These data implicate AHSG in the development of vascular calcified plaque in diabetic subjects.

scholarly journals Polymorphism of the AHSG gene is associated with increased adipocyte β2-adrenoceptor function

2005 ◽  
Vol 46 (10) ◽  
pp. 2278-2281 ◽  
Author(s):  
Catharina Lavebratt ◽  
Elisabeth Dungner ◽  
Johan Hoffstedt
Keyword(s):  
Ahsg Gene

Association of AHSG Gene Polymorphisms with Ischemic Stroke in a Han Chinese Population

2013 ◽  
Vol 51 (11-12) ◽  
pp. 916-926 ◽  
Author(s):  
Shanshan Ma ◽  
Zhiyi He ◽  
Jie Zhao ◽  
Lei Li ◽  
Liying Yuan ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Gene Polymorphisms ◽  
Chinese Population ◽  
Han Chinese ◽  
Han Chinese Population ◽  
Ahsg Gene
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