Liver Acinus Zone 3

2020 ◽  
Author(s):  
Keyword(s):  
Liver Acinus

scholarly journals Adriamycin activity's durational governance of different cell death types and zonality in rat liver acinus. Immunohistochemical studies

2014 ◽  
Vol 58 (1) ◽  
pp. 125-133
Author(s):  
Agnieszka Pedrycz ◽  
Zbigniew Boratyński ◽  
Piotr Siermontowski ◽  
Jacek Mendocha ◽  
Marcin Orłowski ◽  
...  
Keyword(s):  
Cell Death ◽  
Caspase 3 ◽  
Mitochondrial Pathway ◽  
Immunohistochemical Method ◽  
Extrinsic Pathway ◽  
Apoptotic Pathway ◽  
Liver Acinus ◽  
Group I ◽  
Female Wistar Rats ◽  
Immunohistochemical Studies

Abstract The aim of this study was to develop and examine a model of apoptosis and necrosis of hepatocytes induced by a damaging factor - adriamycin, correlating time after its administration with cell death type, and to investigate the localisation within the liver acinus of hepatocytes dying in these two ways. The results obtained in the present and previous studies were compared in order to make a map of cell death localisation in the liver acinus, showing the effect of time in action and dose of adriamycin. The experiment was performed on 32 female Wistar rats, divided into four groups: I and II - experimental, and III and IV - control. Adriamycin (3 mg/kg b.w.) was administered intraperitoneally to rats in groups I and II, and the rats were decapitated after four (group I) and eight (group II) weeks. Animals in control groups III and IV were given 0.5 mL of 0.9% NaCl solution, and decapitated after four and eight weeks respectively. Sections of the liver were examined with a three-stage immunohistochemical method. This method allowed to examine hepatocytes qualitatively and quantitatively for the presence of proteins involved in three types of apoptosis: induced by the mitochondrial pathway (caspase 3, 9), the intrinsic pathway related to endoplasmic reticulum stress (caspase 3, 12), and the extrinsic pathway (caspase 3, 8). One of the inflammatory markers, caspase 1, was also examined. The zonal localisation of all three types of apoptosis was assessed in the liver tissue. More oxidated hepatocytes indicated only signs of the internal mitochondrial pathway, whereas less oxidated hepatocytes induced the internal reticular pathway and the external apoptotic pathway. The period between adriamycin administration and hepatic cell investigation was a main factor of the process. A longer period post insult resulted in a more pronounced effect of the activation of apoptosis. Sections explored eight weeks after treatment with different doses of the drug (3 and 5 mg/kg in the previous study) showed a similar intensity of apoptosis.

The stuctural and functional unit in the human liver (liver acinus)

1958 ◽  
Vol 130 (4) ◽  
pp. 673-689 ◽  
Author(s):  
A. M. Rappaport ◽  
W. D. Wilson
Keyword(s):  
Human Liver ◽  
Functional Unit ◽  
Liver Acinus

Causes of zonal distribution of glycogen in the liver acinus after a fat-rich diet

1973 ◽  
Vol 29 (5) ◽  
pp. 545-546 ◽  
Author(s):  
W. den Otter ◽  
L. F. Blikkendaal-Lieftinck ◽  
J. W. Koten
Keyword(s):  
Zonal Distribution ◽  
Liver Acinus

The location of hepatocytes in the rat liver acinus determines their sensitivity to calcium-mobilizing hormones

1996 ◽  
Vol 111 (5) ◽  
pp. 1343-1352 ◽  
Author(s):  
T Tordjmann ◽  
B Berthon ◽  
L Combettes ◽  
M Claret
Keyword(s):  
Rat Liver ◽  
Liver Acinus

scholarly journals Hypophysectomy does not alter the acinar zonation of gluconeogenesis or the mitochondrial redox state in rat liver

1989 ◽  
Vol 260 (1) ◽  
pp. 183-187 ◽  
Author(s):  
D Tosh ◽  
K G M M Alberti ◽  
L Agius
Keyword(s):  
Alanine Aminotransferase ◽  
Redox State ◽  
Cell Populations ◽  
Hepatic Enzyme ◽  
Hepatic Enzymes ◽  
Functional Heterogeneity ◽  
Liver Acinus ◽  
Mitochondrial Redox State ◽  
Hypophysectomized Rats ◽  
Periportal Zone

The biochemical and functional heterogeneity of hepatocytes in different zones of the liver acinus may be related to the concentrations of hormones within the liver acinus. We examined the effects of hypophysectomy, which causes marked changes in plasma hormone levels and in activities of hepatic enzymes that are normally heterogeneously distributed, on the degree of metabolic zonation within the liver acinus. In hypophysectomized rats the activity of alanine aminotransferase was increased, but its normal zonation (predominance in the periportal zone) was preserved. The activity in cultured periportal and perivenous hepatocytes was increased by dexamethasone, but not by glucagon. Periportal hepatocytes from hypophysectomized rats expressed higher rates of gluconeogenesis in culture than did perivenous hepatocytes, irrespective of the absence or presence of dexamethasone, glucagon or insulin. Similar differences in rates of ketogenesis and in the mitochondrial redox state in response to glucagon were observed between periportal and perivenous hepatocytes from hypophysectomized rats as between cell populations from normal rats. Although hypophysectomy causes marked changes in hepatic enzyme activities, it does not alter the degree of zonation of alanine aminotransferase, gluconeogenesis or the mitochondrial redox state within the liver acinus.

Distribution of alcohol dehydrogenase isoenzymes in the human liver acinus

1999 ◽  
Vol 111 (5) ◽  
pp. 391-397 ◽  
Author(s):  
I. Piotr Maly ◽  
Mireille Toranelli ◽  
D. Sasse
Keyword(s):  
Alcohol Dehydrogenase ◽  
Human Liver ◽  
Alcohol Dehydrogenase Isoenzymes ◽  
Liver Acinus

An Experimental Microangiographic Study on Injured Liver Acinus by Ligation of Common Bile Duct

1994 ◽  
Vol 30 (3) ◽  
pp. 531
Author(s):  
Byung Soo Kim ◽  
Jong Yeon Park ◽  
Ki Ho Moon ◽  
Yoon Gyu Kirn ◽  
Suek Hong Lee ◽  
...  
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Liver Acinus ◽  
Injured Liver
Sign in / Sign up

Export Citation Format

Share Document