scholarly journals Halichondrin B

2020 ◽  
Author(s):  
Keyword(s):  
Halichondrin B

Naturally occurring heterocyclic anticancer compounds

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Shashi Kiran Misra ◽  
Kamla Pathak
Keyword(s):  
Anticancer Agents ◽  
Topoisomerase I ◽  
Heterocyclic Ring ◽  
Cytotoxic Action ◽  
Extrinsic Pathway ◽  
Anticancer Compounds ◽  
Halichondrin B ◽  
Naturally Occurring ◽  
Microbial Infections ◽  
Almost All

Abstract Naturally occurring heterocyclic scaffolds are key ingredients for the development of various therapeutics employed for biomedical applications. Heterocyclic pharmacophores are widely disseminated and have been befallen in almost all categories of drugs for the alleviation of myriad ailments including diabetes, neurodegenerative, psychiatric, microbial infections, disastrous cancers etc. Countless fused heterocyclic anticancerous templates are reported to display antimetabolite, antioxidant, antiproliferative, cytostatic etc. pharmacological actions via targeting different signaling pathways (cell cycle, PI-3kinase/Akt, p53, caspase extrinsic pathway etc.), overexpressive receptors (EGRF, HER2, EGF, VEGF etc.) and physiological enzymes (topoisomerase I and II, cyclin dependent kinase etc.). A compiled description on various natural sources (plants, microbes, marine) containing anticancer agents comprising heterocyclic ring specified with presence of nitrogen (vincristine, vinblastine, indole-3-carbinol, meridianins, piperine, lamellarins etc.), oxygen (paclitaxel, halichondrin B, quercetin, myricetin, kaempferol etc.) and sulphur atoms (brugine, fucoidan, carrageenan etc.) are displayed here along with their molecular level cytotoxic action and therapeutic applications.

Synthesis of a C(22)−C(34) Halichondrin B Precursor via Ring Opening−Double Ring Closing Metathesis

1998 ◽  
Vol 63 (24) ◽  
pp. 8626-8627 ◽  
Author(s):  
Steven D. Burke ◽  
Kevin J. Quinn ◽  
Victor J. Chen
Keyword(s):  
Ring Opening ◽  
Ring Closing Metathesis ◽  
Halichondrin B ◽  
Double Ring

An expeditious synthesis of the C(1)-C(14) subunit of halichondrin B

1994 ◽  
Vol 35 (5) ◽  
pp. 703-706 ◽  
Author(s):  
Steven D. Burke ◽  
Kyung Woon Jung ◽  
Jeannie R. Phillips ◽  
Roman E. Perri
Keyword(s):  
Halichondrin B

A Simple but Remarkably Effective Device for Forming the C8−C14 Polycyclic Ring System of Halichondrin B

2004 ◽  
Vol 126 (25) ◽  
pp. 7770-7771 ◽  
Author(s):  
Kosuke Namba ◽  
Hyuk-Sang Jun ◽  
Yoshito Kishi
Keyword(s):  
Ring System ◽  
Halichondrin B
Sign in / Sign up

Export Citation Format

Share Document