Synthetic Studies on Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge. 9. Synthesis of the C16-C36 Unit via Stereoselective Construction of the D and E Rings.

Kiyoshi HORITA; Masaaki NAGASAWA; Youji SAKURAI; Osamu YONEMITSU

doi:10.1248/cpb.46.1199

Synthetic Studies on Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge. 9. Synthesis of the C16-C36 Unit via Stereoselective Construction of the D and E Rings.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.46.1199 ◽

1998 ◽

Vol 46 (8) ◽

pp. 1199-1216 ◽

Cited By ~ 12

Author(s):

Kiyoshi HORITA ◽

Masaaki NAGASAWA ◽

Youji SAKURAI ◽

Osamu YONEMITSU

Keyword(s):

Marine Sponge ◽

Halichondrin B ◽

Synthetic Studies

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Synthetic Studies of Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge. 6. Synthesis of the C1-C15 Unit via Stereoselective Construction of the B and A Rings by Kinetically and Thermodynamically Controlled Michael Reactions with the Aid of Computational Search for Dominant Conformers.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.45.1265 ◽

1997 ◽

Vol 45 (8) ◽

pp. 1265-1281 ◽

Cited By ~ 16

Author(s):

Kiyoshi HORITA ◽

Shun-ichiro HACHIYA ◽

Tatsuya YAMAZAKI ◽

Tae NAITOU ◽

Jun'ichi UENISHI ◽

...

Keyword(s):

Marine Sponge ◽

Halichondrin B ◽

Michael Reactions ◽

Computational Search ◽

Synthetic Studies

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Synthetic Studies of Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge. 1. Stereoselective Synthesis of the C1-C13 FragmentviaConstruction of the B and A Rings by Kinetically and thermodynamically Controlled Intramolecular Michael Reactions.

Synlett ◽

10.1055/s-1994-22730 ◽

1994 ◽

Vol 1994 (01) ◽

pp. 38-40 ◽

Cited By ~ 26

Author(s):

K. Horita ◽

S. Hachiya ◽

M. Nagasawa ◽

M. Hikota ◽

O. Yonemitsu

Keyword(s):

Marine Sponge ◽

Stereoselective Synthesis ◽

Halichondrin B ◽

Michael Reactions ◽

Synthetic Studies

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ChemInform Abstract: Synthetic Studies of Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge. Part 5. A Highly Concise and Efficient Synthesis of the C37-C54 Tricyclic JKL-Ring Part.

ChemInform ◽

10.1002/chin.199617240 ◽

2010 ◽

Vol 27 (17) ◽

pp. no-no

Author(s):

K. HORITA ◽

S. HACHIYA ◽

K. OGIHARA ◽

Y. YOSHIDA ◽

M. NAGASAWA ◽

...

Keyword(s):

Marine Sponge ◽

Efficient Synthesis ◽

Halichondrin B ◽

Synthetic Studies

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Synthetic studies of halichondrin B, an antitumor polyether macrolide isolated from a marine sponge. 8. Synthesis of the lactone part (C1C36) via horner-emmons coupling between C1C15 and C16C36 fragments and Yamaguchi lactonization

Tetrahedron Letters ◽

10.1016/s0040-4039(97)10364-1 ◽

1997 ◽

Vol 38 (52) ◽

pp. 8965-8968 ◽

Cited By ~ 11

Author(s):

Kiyoshi Horita ◽

Masaaki Nagasawa ◽

Shun-ichiro Hachiya ◽

Youji Sakurai ◽

Tatsuya Yamazaki ◽

...

Keyword(s):

Marine Sponge ◽

Halichondrin B ◽

Synthetic Studies

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Synthetic Studies of Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge. 7. Synthesis of Two C27-C36 Units via Construction of the F Ring and Completely Stereoselective C-Glycosylation Using Mixed Lewis Acids.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.45.1558 ◽

1997 ◽

Vol 45 (10) ◽

pp. 1558-1572 ◽

Cited By ~ 17

Author(s):

Kiyoshi HORITA ◽

Youji SAKURAI ◽

Masaaki NAGASAWA ◽

Osamu YONEMITSU

Keyword(s):

Marine Sponge ◽

Lewis Acids ◽

Halichondrin B ◽

Synthetic Studies ◽

F Ring

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Synthetic Studies of Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge. 2. Efficient Synthesis of C16-C26 FragmentsviaConstruction of the D Ring by a Highly Stereocontrolled Iodoetherification

Synlett ◽

10.1055/s-1994-22731 ◽

1994 ◽

Vol 1994 (01) ◽

pp. 40-43 ◽

Cited By ~ 10

Author(s):

K. Horita ◽

M. Nagasawa ◽

S. Hachiya ◽

O. Yonemitsu

Keyword(s):

Marine Sponge ◽

Efficient Synthesis ◽

Halichondrin B ◽

Synthetic Studies

Download Full-text

ChemInform Abstract: Synthetic Studies of Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge. Part 7. Synthesis of Two C27-C36 Units via Construction of the F Ring and Completely Stereoselective C-Glycosylation Using Mixed Lewi

ChemInform ◽

10.1002/chin.199814201 ◽

2010 ◽

Vol 29 (14) ◽

pp. no-no

Author(s):

K. HORITA ◽

Y. SAKURAI ◽

M. NAGASAWA ◽

O. YONEMITSU

Keyword(s):

Marine Sponge ◽

Halichondrin B ◽

Synthetic Studies ◽

F Ring

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Synthetic Studies of Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge. 4. Synthesis of the C37-C54 SubunitviaStereoselective Construction of Three Consecutive J, K, and L Rings

Synlett ◽

10.1055/s-1994-22733 ◽

1994 ◽

Vol 1994 (01) ◽

pp. 46-48 ◽

Cited By ~ 15

Author(s):

K. Horita ◽

Y. Sakurai ◽

M. Nagasawa ◽

K. Maeno ◽

S. Hachiya ◽

...

Keyword(s):

Marine Sponge ◽

Halichondrin B ◽

Synthetic Studies

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ChemInform Abstract: Synthetic Studies on Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge. Part 9. Synthesis of the C16-C36 Unit via Stereoselective Construction of the D and E Rings.

ChemInform ◽

10.1002/chin.199906237 ◽

2010 ◽

Vol 30 (6) ◽

pp. no-no

Author(s):

K. HORITA ◽

M. NAGASAWA ◽

Y. SAKURAI ◽

O. YONEMITSU

Keyword(s):

Marine Sponge ◽

Halichondrin B ◽

Synthetic Studies

Download Full-text

Synthetic Studies of Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge. 3. Synthesis of C27-C36 SubunitviaCompletely StereoselectiveC-Glycosylation to the F Ring

Synlett ◽

10.1055/s-1994-22732 ◽

1994 ◽

Vol 1994 (01) ◽

pp. 43-45 ◽

Cited By ~ 35

Author(s):

K. Horita ◽

Y. Sakurai ◽

M. Nagasawa ◽

S. Hachiya ◽

O. Yonemitsu

Keyword(s):

Marine Sponge ◽

Halichondrin B ◽

Synthetic Studies ◽

F Ring

Download Full-text