scholarly journals Atypical Neurofibroma

2020 ◽  
Author(s):  
Keyword(s):  
Atypical Neurofibroma

Cutaneous Atypical Neurofibroma

2018 ◽  
Vol 40 (11) ◽  
pp. 864-867
Author(s):  
Nima Mesbah Ardakani ◽  
Ferlin Yap ◽  
Benjamin A. Wood
Keyword(s):  
Atypical Neurofibroma

scholarly journals Atypical Neurofibroma and Osteosclerotic Metastasis

2012 ◽  
Vol 2012 ◽  
pp. 1-4
Author(s):  
Neeraj Varyani ◽  
Anubhav Thukral ◽  
Sunny Garg ◽  
Kailash Kumar Gupta ◽  
Ravi Tandon ◽  
...  
Keyword(s):  
Systemic Corticosteroid ◽  
Bone Marrow Aspiration ◽  
Metastatic Lesion ◽  
Intrathecal Methotrexate ◽  
Resonance Imaging ◽  
Eosinophilic Cytoplasm ◽  
Magnetic Resonance Imaging Mri ◽  
Generalized Lymphadenopathy ◽  
Brain And Spinal Cord ◽  
Atypical Neurofibroma

35-year-old male presented with multiple swellings in left leg, headache, weakness of limbs for 4 months, and blurring of vision for the last 15 days. On examination, he was pale, cachexic with generalized lymphadenopathy and lower motor neuron type weakness of limbs sparing right upper limb. Blood investigations showed anemia with high alkaline phosphatase. Chest radiograph revealed osteosclerotic metastatic lesion in humerus. Biopsy of leg lesion revealed atypical neurofibroma. Computed tomography (CT) of thorax revealed osteoblastic metastasis. Bone marrow aspiration showed cells with round to oval nuclei, fine granular chromatin with large central prominent nucleoli and eosinophilic cytoplasm with acini formation. Magnetic resonance imaging (MRI) of brain and spinal cord defined metastatic leptomeningeal deposits. Cerebrospinal fluid (CSF) cytology was positive for malignant cells. Gastroscopy showed an ulceroinfiltrative growth from stomach which on histopathology revealed diffuse adenocarcinoma. Palliative treatment was given with intrathecal methotrexate and systemic corticosteroid with chemotherapy. Patient’s symptom improved drastically, but we lost him to followup.

Podoplanin and CD34 in peripheral nerve sheath tumours: focus on neurofibromatosis 1-associated atypical neurofibroma

2010 ◽  
Vol 103 (2) ◽  
pp. 239-245 ◽  
Author(s):  
Urs Naber ◽  
Reinhard E. Friedrich ◽  
Markus Glatzel ◽  
Victor Felix Mautner ◽  
Christian Hagel
Keyword(s):  
Peripheral Nerve ◽  
Neurofibromatosis 1 ◽  
Nerve Sheath ◽  
Atypical Neurofibroma

scholarly journals Cdkn2a Loss in a Model of Neurofibroma Demonstrates Stepwise Tumor Progression to Atypical Neurofibroma and MPNST

2020 ◽  
Vol 80 (21) ◽  
pp. 4720-4730
Author(s):  
Katherine E. Chaney ◽  
Melissa R. Perrino ◽  
Leah J. Kershner ◽  
Ami V. Patel ◽  
Jianqiang Wu ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Atypical Neurofibroma

scholarly journals The effect of surgical margins on outcomes for low grade MPNSTs and atypical neurofibroma

2014 ◽  
Vol 110 (7) ◽  
pp. 813-816 ◽  
Author(s):  
Nicholas M. Bernthal ◽  
Angelica Putnam ◽  
Kevin B. Jones ◽  
David Viskochil ◽  
R Lor Randall
Keyword(s):  
Surgical Margins ◽  
Low Grade ◽  
Atypical Neurofibroma

scholarly journals Peripheral Nerve Sheath Tumors Resembling Human Atypical Neurofibroma in Goldfish (Carassius auratus, Linnaeus, 1758)

Animals ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 2621
Author(s):  
Federico Armando ◽  
Claudio Pigoli ◽  
Matteo Gambini ◽  
Andrea Ghidelli ◽  
Gabriele Ghisleni ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Carassius Auratus ◽  
S100 Protein ◽  
Nerve Sheath Tumors ◽  
Peripheral Nerve Sheath Tumors ◽  
Goldfish Carassius Auratus ◽  
Nerve Sheath ◽  
Minimal Subset ◽  
Skin Nodules ◽  
Atypical Neurofibroma

Skin spindle cell tumors (SSTs) frequently occur in fishes, with peripheral nerve sheath tumors (PNSTs) being the most commonly reported neoplasms in goldfish. However, distinguishing PNSTs from other SCTs is not always possible when relying exclusively on routine cytological and histopathological findings. Therefore, the aim of this study is to characterize six skin nodules, resembling atypical neurofibromas in humans, found in six cohabiting goldfish (Carassius auratus), and to determine a minimal subset of special stains required to correctly identify PNSTs in this species. Routine cytology and histopathology were indicative of an SCT with nuclear atypia in all cases, with randomly distributed areas of hypercellularity and loss of neurofibroma architecture. Muscular and fibroblastic tumors were excluded using Azan trichrome staining. Alcian blue and Gomori’s reticulin stains revealed the presence of intratumoral areas of glycosaminoglycans or mucins and basement membrane fragments, respectively. PAS and PAS–diastase stains confirmed the latter finding and revealed intra- and extracellular glycogen granules. Immunohistochemistry displayed multifocal, randomly distributed aggregates of neoplastic cells positive for S100 protein and CNPase, intermingled with phosphorylated and non-phosphorylated neurofilament-positive axons. Collectively, these findings are consistent with a PNST resembling atypical neurofibroma in humans, an entity not previously reported in goldfish, and suggest that Azan trichrome staining, reticulin staining, and immunohistochemistry for S100 protein and CNPase represent a useful set of special stains to identify and characterize PNSTs in this species.

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