scholarly journals NANOG Gene

2020 ◽  
Author(s):  
Keyword(s):  
Nanog Gene

NANOG gene suppression and replacement of let-7 modulate the stemness, invasion, and apoptosis in breast cancer

Gene ◽  
2021 ◽  
pp. 145844
Author(s):  
Zeynab Aliyari Serej ◽  
Ayyub Ebrahimi ◽  
Tohid Kazemi ◽  
Souzan Najafi ◽  
Mohammad Amini ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Suppression ◽  
Nanog Gene

scholarly journals Epigenetic regulation of Nanog gene in embryonic stem and trophoblast stem cells

2007 ◽  
Vol 12 (3) ◽  
pp. 387-396 ◽  
Author(s):  
Naoko Hattori ◽  
Yuko Imao ◽  
Koichiro Nishino ◽  
Naka Hattori ◽  
Jun Ohgane ◽  
...  
Keyword(s):  
Stem Cells ◽  
Epigenetic Regulation ◽  
Embryonic Stem ◽  
Trophoblast Stem Cells ◽  
Trophoblast Stem ◽  
Nanog Gene

scholarly journals Insights into the Nanog gene: A propeller for stemness in primitive stem cells

2016 ◽  
Vol 12 (11) ◽  
pp. 1372-1381 ◽  
Author(s):  
Wei Zhang ◽  
Yi Sui ◽  
Jun Ni ◽  
Tao Yang
Keyword(s):  
Stem Cells ◽  
Nanog Gene

Nanog gene: Genomic organization and expression in the vole Microtus rossiaemeridionalis

2009 ◽  
Vol 425 (1) ◽  
pp. 102-105 ◽  
Author(s):  
S. P. Medvedev ◽  
E. A. Elisaphenko ◽  
A. I. Shevchenko ◽  
N. A. Mazurok ◽  
S. M. Zakian
Keyword(s):  
Genomic Organization ◽  
Microtus Rossiaemeridionalis ◽  
Nanog Gene

Identification of the OCT4-pg1 retrogene and NANOG gene expression in the human fetal eye

2008 ◽  
Vol 35 (2) ◽  
pp. 108-112 ◽  
Author(s):  
N. V. Firsova ◽  
Yu. V. Markitantova ◽  
Yu. A. Smirnova ◽  
I. G. Panova ◽  
G. T. Sukhikh ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nanog Gene

scholarly journals Significance of stem cell marker Nanog gene in the diagnosis and prognosis of lung cancer

2016 ◽  
Vol 12 (4) ◽  
pp. 2507-2510 ◽  
Author(s):  
Zeng Liu ◽  
Jing Zhang ◽  
Honggang Kang ◽  
Guiming Sun ◽  
Baozhong Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Stem Cell ◽  
Stem Cell Marker ◽  
Cell Marker ◽  
Diagnosis And Prognosis ◽  
Nanog Gene

The synergistic effect of 5Azadc and TSA on maintenance of pluripotency of chicken ESCs by overexpression of NANOG gene

2016 ◽  
Vol 52 (4) ◽  
pp. 488-496
Author(s):  
Xiaoyan Wang ◽  
Yingjie Wang ◽  
Qisheng Zuo ◽  
Dong Li ◽  
Wenhui Zhang ◽  
...  
Keyword(s):  
Synergistic Effect ◽  
Nanog Gene

scholarly journals Repression of Nanog Gene Transcription by Tcf3 Limits Embryonic Stem Cell Self-Renewal

2006 ◽  
Vol 26 (20) ◽  
pp. 7479-7491 ◽  
Author(s):  
Laura Pereira ◽  
Fei Yi ◽  
Bradley J. Merrill
Keyword(s):  
Stem Cells ◽  
Transcription Factors ◽  
Molecular Mechanisms ◽  
Inner Cell Mass ◽  
Cell Mass ◽  
Regulatory Region ◽  
Embryonic Stem ◽  
Dual Function ◽  
Self Renewal ◽  
Nanog Gene

ABSTRACT The dual function of stem cells requires them not only to form new stem cells through self-renewal but also to form lineage-committed cells through differentiation. Embryonic stem cells (ESC), which are derived from the blastocyst inner cell mass, retain properties of self-renewal and the potential for lineage commitment. To balance self-renewal and differentiation, ESC must carefully control the levels of several transcription factors, including Nanog, Sox2, and Oct4. While molecular mechanisms promoting transcription of these genes have been described, mechanisms preventing excessive levels in self-renewing ESC remain unknown. By examining the function of the TCF family of transcription factors in ESC, we have found that Tcf3 is necessary to limit the steady-state levels of Nanog mRNA, protein, and promoter activity in self-renewing ESC. Chromatin immunoprecipitation and promoter reporter assays showed that Tcf3 bound to a promoter regulatory region of the Nanog gene and repressed its transcriptional activity in ESC through a Groucho interaction domain-dependent process. The absence of Tcf3 caused delayed differentiation of ESC in vitro as elevated Nanog levels persisted through 5 days of embryoid body formation. These new data support a model wherein Tcf3-mediated control of Nanog levels allows stem cells to balance the creation of lineage-committed and undifferentiated cells.

scholarly journals Isolation and characterization of the murine Nanog gene promoter

Cell Research ◽  
2005 ◽  
Vol 15 (5) ◽  
pp. 317-324 ◽  
Author(s):  
Da Yong WU ◽  
Zhen YAO
Keyword(s):  
Gene Promoter ◽  
Isolation And Characterization ◽  
Nanog Gene

scholarly journals Relation between Immune cell response and stemness genes expression in breast cancer; A new approach in NANOG gene and Let7-a expression in breast cancer cell lines

2020 ◽  
Vol 6 (2) ◽  
pp. e21-e21
Author(s):  
Zeynab Aliyari-Serej ◽  
Ayyub Ebrahimi ◽  
Tohid Kazemi ◽  
Souzan Najafi ◽  
Elmira Roshani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Immune Cells ◽  
Immune Cell ◽  
Preclinical Study ◽  
Breast Cancer Cell Lines ◽  
Developmental Behavior ◽  
Genes Expression ◽  
Nanog Gene ◽  
Immune Cell Response

Introduction: Failure and recurrence in breast cancer treatment cause a great obstacle in cancer therapy and identification of cell population named cancer stem cells (CSCs) in the tumor can be led us to define it as target in novel therapeutic strategy. Objectives: The aim of this study is the finding of correlation between stemness and metastatic characteristic, also knowing CSCs as a potential target of therapy because of its developmental behavior and similarities with normal stem cells. Materials and Methods: Here, we focus on the expression of NANOG in breast CSCs, a key molecule in the physiological process of stem cells and the Let-7a that is involved in the differentiation of the cells. Results: In this work, we found that NANOG was highly expressed in SKBR3 and down-regulation of let-7a, as a differentiation miRNA, was found in MDA-MB-468 cells. Conclusion: It will be critical for the developing of effective anti-tumor drugs, utilizing mentioned concepts. Inhibition of NANOG in combination with Let-7a up-regulation can help to decrease the stemness and increase the differentiation of CSCs. The decrease of stemness and increase of differentiation initiate the apoptotic process. So, modification in the mechanism of apoptosis beside anti-cancer drugs provide a good preclinical study goal. However, in order to these drugs become clinical, the problems of their side effects and toxicity must be solved. Differentiation of CSCs provides an optimal condition to activity of immune cells which never let them escape from immune cells by alteration of immunogenicity.

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