scholarly journals Inconclusive Result

2019 ◽  
Author(s):  
Keyword(s):  
Inconclusive Result

scholarly journals 460. Point-of-Care, In-Home SARS-CoV-2 IgG Antibody Testing to Assess Seroprevalence in At-Risk Health Care Workers

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S297-S297
Author(s):  
Eric G Meissner ◽  
Christine Litwin ◽  
Tricia Crocker ◽  
Elizabeth Mack ◽  
Lauren Card
Keyword(s):  
Health Care ◽  
At Risk ◽  
Health Care Workers ◽  
Medical Center ◽  
Point Of Care ◽  
Academic Medical Center ◽  
Significant Risk ◽  
Documented Infection ◽  
Inconclusive Result ◽  
Care Workers

Abstract Background Health care workers are at significant risk for infection with the novel coronavirus SARS-CoV-2. Methods We utilized a point-of-care, lateral flow SARS-CoV-2 IgG immunoassay (RayBiotech) to conduct a seroprevalence study in a cohort of at-risk health care workers (n=339) and normal-risk controls (n=100) employed at an academic medical center. To minimize exposure risk while conducting the study, consents were performed electronically, tests were mailed and then self-administered at home using finger stick blood, and subjects uploaded a picture of the test result while answering an electronic questionnaire. We also validated the assay using de-identified serum samples from patients with PCR-proven SARS-CoV-2 infection. Results Between April 14th and May 6th 2020, 439 subjects were enrolled. Subjects were 68% female, 93% white, and most were physicians (38%) and nurses (27%). In addition, 37% had at least 1 respiratory symptom in the prior month, 34% had cared for a patient with known SARS-CoV-2 infection, 57% and 23% were worried about exposure at work or in the community, respectively, and 5 reported prior documented SARS-CoV-2 infection. On initial testing, 3 subjects had a positive IgG test, 336 had a negative test, and 87 had an inconclusive result. Of those with an inconclusive result who conducted a repeat test (85%), 96% had a negative result. All 3 positive IgG tests were in subjects reporting prior documented infection. Laboratory validation showed that of those with PCR-proven infection more than 13 days prior, 23/30 were IgG positive (76% sensitivity), whereas 1/26 with a negative prior PCR test were seropositive (95% specificity). Repeat longitudinal serologic testing every 30 days for up to 4 times is currently in progress. Conclusion We conducted a contact-free study in the setting of a pandemic to assess SARS-CoV-2 seroprevalence in an at-risk group of health care workers. The only subjects found to be IgG positive were those with prior documented infection, even though a substantial proportion of subjects reported significant potential occupational or community exposure and symptoms that were potentially compatible with SARS-COV-2 infection. Disclosures All Authors: No reported disclosures

Differences in radioimmunoassay results for thyroglobulin that affect management of patients with thyroid cancer.

1984 ◽  
Vol 30 (1) ◽  
pp. 81-86 ◽  
Author(s):  
M F Bayer ◽  
I R McDougall
Keyword(s):  
Differentiated Thyroid Carcinoma ◽  
Medical Systems ◽  
Serum Thyroglobulin ◽  
Clinical Specimens ◽  
Inconclusive Result ◽  
Thyroglobulin Autoantibodies ◽  
Thyroglobulin Concentration ◽  
Positive Results ◽  
Disease Free ◽  
Good Agreement

Abstract We compared two commercial assays for measurement of serum thyroglobulin [Nuclear Medical Systems (NMS) and "CIS" (Damon Diagnostics)] with each other and with one developed at Stanford (J Clin Endocrinol Metab 49:557-564, 1979). The NMS assay is a competitive-binding RIA, the CIS and Stanford assays are two-site immunoradiometric assays. The kit standards varied in thyroglobulin concentration. The NMS standards differed in immunoreactivity from thyroglobulin in clinical specimens and from the other standards. Also, nonparallelism between standards and patients' sera in the NMS assay suggested a less-specific antiserum. Results by the CIS and Stanford assays correlated well (n = 120, r = 0.964), those by the NMS assay less strongly (n = 101, r = 0.855 vs CIS, r = 0.888 vs Stanford). Clinical evaluation in 50 patients treated for differentiated thyroid carcinoma (10 with metastases and 40 currently disease-free) indicated good agreement for positive results by the three assays. The CIS and the Stanford assay both gave high results (greater than or equal to 25 micrograms/L) in all 10 cases with metastases; the NMS RIA identified eight of these patients (thyroglobulin greater than or equal to 30 micrograms/L), but excluded two with anti-thyroglobulin autoantibodies. In subjects without disease, however, the percentage of undetectable thyroglobulin (negative result), as opposed to low measurable thyroglobulin (inconclusive result) varied considerably: 85% by CIS, 30% by NMS, and 75% by the Stanford assay.

scholarly journals Uncertainty following an inconclusive result from the BRCA1/2 genetic test: A review about psychological outcomes

2021 ◽  
Vol 11 (5) ◽  
pp. 189-200
Author(s):  
Sonia Monique Bramanti ◽  
Carmen Trumello ◽  
Lucia Lombardi ◽  
Alessandra Cavallo ◽  
Liborio Stuppia ◽  
...  
Keyword(s):  
Genetic Test ◽  
Psychological Outcomes ◽  
Inconclusive Result

scholarly journals Using Personality Tests to Identify Potential ICT Entrepreneurs

10.28945/3160 ◽  
2007 ◽  
Author(s):  
Kevin Johnston ◽  
Barry Andersen ◽  
Jennifer Davidge-Pitts ◽  
Mark Ostensen-Saunders
Keyword(s):  
Population Sample ◽  
Personality Types ◽  
Personality Characteristics ◽  
Personality Tests ◽  
Keirsey Temperament Sorter ◽  
Inconclusive Result ◽  
Entrepreneurial Ability ◽  
University Of Cape Town ◽  
The University ◽  
The Impact

Literature relating to personality and entrepreneurship has focused primarily on personality characteristics of traditional entrepreneurs. The focus of this study was on personality characteristics and temperaments of potential ICT entrepreneurs. The main objective of the study was to evaluate the impact of personality characteristics as identifiers of potential ICT entrepreneurship. In order to meet this objective, the personality characteristics of the participants had to be determined. The Keirsey Temperament Sorter was used as a personality indicator, as it is a proven research instrument. Two entrepreneurial tests were used to determine entrepreneurial ability. The temperament of the individuals was ascertained, and compared to their entrepreneurial ability. The population sample used for this study was comprised of third year and honours information systems students from the University of Cape Town, and current ICT entrepreneurs. A positive relationship between the “Martian” temperaments and potential ICT entrepreneurs was found. No significant relationship between specific personality types and potential entrepreneurial ability were evident in the study. A positive connection was noticed between potential ICT entrepreneurs, and being male. Unfortunately the number of female respondents was insufficient, leading to an inconclusive result.

ECB QE and growth may obscure Polish political risk

2015 ◽  
Keyword(s):  
Financial Markets ◽  
Interest Rates ◽  
Federal Reserve ◽  
Economic Recovery ◽  
Coalition Government ◽  
Parliamentary Election ◽  
Quantitative Easing ◽  
Content Type ◽  
Inconclusive Result ◽  
The Us

Significance Having fallen against the resurgent dollar this year, the zloty has lately been strengthening, since the US Federal Reserve surprised financial markets by striking a more dovish stance than expected on both the timing and pace of the anticipated tightening in monetary policy. While the zloty and Polish stocks had suffered because of fears of a rise in US interest rates, local bonds have been underpinned by the ECB's quantitative easing (QE) programme. The effects of QE and a brisker economic recovery may temporarily offset the risk of an inconclusive result in the parliamentary election in October. Impacts Investors have yet to price in the risk of a hung parliament in Poland following October's election. The vote could lead to the formation of a weak and unstable coalition government. The risk of an unstable coalition is particularly high, given the strong likelihood that PO's share of the vote will decline sharply.

Next EU summit may alter some of Turkish migrant deal

2016 ◽  
Keyword(s):  
European Council ◽  
Refugee Crisis ◽  
Political Pressure ◽  
Content Type ◽  
Inconclusive Result ◽  
Turkish Migrant ◽  
The Eu

Significance Leaders have tried to put a positive spin on the inconclusive result, insisting they outlined the main principles of a deal and would work out details over the next ten days before convening again at the scheduled March 17-18 European Council summit to conclude an agreement. Impacts EU leaders are desperate to find a common approach to the refugee crisis before it leads to complete unravelling of the Schengen area. Such leaders as Germany's Merkel face huge political pressure to reduce the refugee influx which is fuelling support for extremist parties. If the plan works, it may lift the severe pressure on Greece by reducing the inflow of migrants and allowing relocation in the EU.

1060 Screening For Obstructive Sleep Apnea In Severe Gastroesophageal Reflux Disease Patients: A Forgotten Association?

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A403-A403
Author(s):  
A De ◽  
H Gharib ◽  
D Frenia ◽  
S Velpari
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Ph Monitoring ◽  
Intermediate Risk ◽  
Inconclusive Result ◽  
Obstructive Sleep ◽  
History Of

Abstract Introduction Obstructive sleep apnea (OSA) is an emerging epidemic in the USA and remains underdiagnosed. Investigations of Gastroesophageal reflux disease (GERD) poses a substantial burden on patient-welfare and costs to the health system. Current literature has highlighted the association between severe GERD and OSA, and other sleep disorders. We conducted a retrospective analysis of patient records undergoing Bravo pH monitoring for refractory GERD to measure the prevalence of OSA and screening. Methods Records of patients who underwent outpatient Bravo pH monitoring at a teaching hospital were reviewed from August 2018 to May 2019. 72 records were reviewed in our analysis. Analysis variables included age, gender, body mass index, history of hypertension and OSA. Outpatient records were reviewed for documentation for OSA or screening and demographics were obtained for calculation of a partial STOP-BANG score (a validated OSA screening tool). Results 8 out of 72 (11%) were excluded due to incomplete documentation regarding their history. Of the remaining 64, 2 had a known diagnosis of OSA (3%) and 1 was due a sleep study for maintenance insomnia. Of the remaining 61 patients, none had documentation of a history pertaining to sleep complaints or full screening for OSA. 4 of the 8 components to the STOP-BANG criteria were documented and used to measure risk of OSA in these patients. 23 (39%) patients had a score of 3 or above characterizing them as intermediate risk. The other 4 components were not used due to a lack of clinical information. 13 of these patients had a positive Bravo test, 2 had an inconclusive result and 8 had a negative result. Of the 61 patients in total, 31 had a positive Bravo result and 9 had an inconclusive result. Conclusion In our study, we found that 39% of patients based on demographic data were of intermediate risk of OSA. Over half of these patients had a positive result for GERD. Despite the increased awareness of sleep disorders it is still neglected despite prevalent associated comorbid conditions. This study highlights the failure to screen for this modifiable risk factor within a teaching environment. Support None

scholarly journals The US CDC RT-PCR probes for the Wuhan 2019-nCoV are non-specific for SARS - there is a better non-specific 500bp option (21852-22427) within the spike-protein

2020 ◽  
Author(s):  
Sandeep Chakraborty
Keyword(s):  
Virulent Strain ◽  
Spike Protein ◽  
World Health ◽  
Genomic Fragment ◽  
Rt Pcr ◽  
Inconclusive Result ◽  
The Us ◽  
The World ◽  
Significant Homology ◽  
Health Organization

The World Health Organization has declared the Wuhan coronavirus [1–3] outbreak a public health emer- gency on 30th Jan, 2020. An accurate detection of the Wuhan virus is imperative to avoid false positives, since 2019-nCoV [2,3] shares significant homology [4] with other species.On the 24th of Jan, the CDC has published a list of 3 probes (Fig 1) for detecting the 2019-nCoV. Detection of all three probes would give a positive result, while detection of one or two gives an ’inconclusive result’ (and obviously negative when none are found).All 3 probes will have significant homology in other strains (Table 1 and Fig 2 ) - specifically SARS (Severe Acute Respiratory Syndrome). A much more specific option is to look within a 500bp genomic fragment in the N-terminal of the spike protein (Accid:NC 045512.2 [2],21852-22427, SI.cdc:nCoVFULLSLICE.fa), which seems to the most perturbed in this virulent strain [5].It is also important to have a common repository for all countries to be following a similar protocol. Many papers do no provide what PCR was used to detect coronaviruses [6].

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