scholarly journals Creatinine Excretion Rate

2020 ◽  
Author(s):  
Keyword(s):  
Excretion Rate ◽  
Creatinine Excretion ◽  
Creatinine Excretion Rate

scholarly journals Variability of Urinary Creatinine in Healthy Individuals

2021 ◽  
Vol 18 (6) ◽  
pp. 3166
Author(s):  
Gerd Sallsten ◽  
Lars Barregard
Keyword(s):  
Flow Rate ◽  
Excretion Rate ◽  
Time Of Day ◽  
Urinary Flow Rate ◽  
Urinary Flow ◽  
Diurnal Variability ◽  
Creatinine Excretion ◽  
Blood Samples ◽  
Urinary Creatinine ◽  
Creatinine Excretion Rate

Many urinary biomarkers are adjusted for dilution using creatinine or specific gravity. The aim was to evaluate the variability of creatinine excretion, in 24 h and spot samples, and to describe an openly available variability biobank. Urine and blood samples were collected from 60 healthy non-smoking adults, 29 men and 31 women. All urine was collected at six time points during two 24 h periods. Blood samples were also collected twice and stored frozen. Analyses of creatinine in urine was performed in fresh urine using an enzymatic method. For creatinine in urine, the intra-class correlation (ICC) was calculated for 24 h urine and spot samples. Diurnal variability was examined, as well as association with urinary flow rate. The creatinine excretion rate was lowest in overnight samples and relatively constant in the other five samples. The creatinine excretion rate in each individual was positively correlated with urinary flow rate. The creatinine concentration was highest in the overnight sample and at 09:30. For 24 h samples the ICC was 0.64, for overnight samples it was 0.5, and for all spot samples, it was much lower. The ICC for urinary creatinine depends on the time of day of sampling. Frozen samples from this variability biobank are open for researchers examining normal variability of their favorite biomarker(s).

scholarly journals Creatinine Excretion Rate and Mortality in Type 2 Diabetes and Nephropathy

Diabetes Care ◽  
2013 ◽  
Vol 36 (6) ◽  
pp. 1489-1494 ◽  
Author(s):  
S. J. Sinkeler ◽  
A. J. Kwakernaak ◽  
S. J. L. Bakker ◽  
S. Shahinfar ◽  
E. Esmatjes ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Excretion Rate ◽  
Creatinine Excretion ◽  
Creatinine Excretion Rate

scholarly journals Complementary Biomarker Assessment of Components Absorbed from Diet and Creatinine Excretion Rate Reflecting Muscle Mass in Dialysis Patients

Nutrients ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1827 ◽  
Author(s):  
Adrian Post ◽  
Akin Ozyilmaz ◽  
Ralf Westerhuis ◽  
Karin Ipema ◽  
Stephan Bakker ◽  
...  
Keyword(s):  
Dietary Intake ◽  
Muscle Mass ◽  
Protein Intake ◽  
Excretion Rate ◽  
Protein Energy Malnutrition ◽  
Dialysis Patients ◽  
Sodium Potassium ◽  
Waste Products ◽  
Creatinine Excretion ◽  
Creatinine Excretion Rate

To prevent protein energy malnutrition (PEM) and accumulation of waste products, dialysis patients require diet adjustments. Dietary intake assessed by self-reported intakes often provides biased information and standard 24-h urinary excretion is inapplicable in dialysis patients. We aimed to assess dietary intake via a complementary, less biased biomarker method, and to compare this to dietary diaries. Additionally, we investigated the prospective association of creatinine excretion rate (CER) reflecting muscle mass with mortality. Complete intradialytic dialysate and interdialytic urinary collections were used to calculate 24-h excretion of protein, sodium, potassium, phosphate and creatinine in 42 chronic dialysis patients and compared with protein, sodium, potassium, and phosphate intake assessed by 5-day dietary diaries. Cox regression analyses were employed to investigate associations of CER with mortality. Mean age was 64 ± 13 years and 52% were male. Complementary biomarker assessed (CBA) and dietary assessed (DA) protein intake were significantly correlated (r = 0.610; p < 0.001), but there was a constant bias, as dietary diaries overestimated protein intake in most patients. Correlations were found between CBA and DA sodium intake (r = 0.297; p = 0.056), potassium intake (r = 0.312; p = 0.047) and phosphate uptake/intake (r = 0.409; p = 0.008). However, Bland-Altman analysis showed significant proportional bias. During a median follow-up of 26.6 (25.3–31.5) months, nine dialysis patients (23%) died. CER was independently and inversely associated with survival (HR: 0.59 (0.42–0.84); p = 0.003). Excretion measurements may be a more reliable assessment of dietary intake in dialysis patients, as this method is relatively free from biases known to exist for self-reported intakes. CER seems to be a promising tool for monitoring PEM.

scholarly journals Non-inferiority of creatinine excretion rate to urinary L-FABP and NGAL as predictors of early renal allograft function

2014 ◽  
Vol 15 (1) ◽  
Author(s):  
Jernej Pajek ◽  
Andrej Škoberne ◽  
Klara Šosterič ◽  
Barbara Adlešič ◽  
Bojan Leskošek ◽  
...  
Keyword(s):  
Renal Allograft ◽  
Excretion Rate ◽  
Creatinine Excretion ◽  
Allograft Function ◽  
Creatinine Excretion Rate

scholarly journals Indicators of lean body mass catabolism: emphasis on the creatinine excretion rate

QJM ◽  
2008 ◽  
Vol 101 (3) ◽  
pp. 197-205 ◽  
Author(s):  
A.P.C.P. Carlotti ◽  
D. Bohn ◽  
A.K. Matsuno ◽  
D.M. Pasti ◽  
M. Gowrishankar ◽  
...  
Keyword(s):  
Lean Body Mass ◽  
Body Mass ◽  
Excretion Rate ◽  
Creatinine Excretion ◽  
Creatinine Excretion Rate

Creatinine Excretion as An Index of Myofibrillar Protein Mass in Dystrophic Mice

1981 ◽  
Vol 61 (6) ◽  
pp. 737-741 ◽  
Author(s):  
C. E. Murray ◽  
D. M. Warnes ◽  
F. J. Ballard ◽  
F. M. Tomas
Keyword(s):  
Excretion Rate ◽  
Myofibrillar Protein ◽  
Strongly Correlated ◽  
Creatinine Excretion ◽  
Protein Mass ◽  
Live Body Weight ◽  
Valid Index ◽  
Dystrophic Mice ◽  
Murine Dystrophy ◽  
Creatinine Excretion Rate

1. Daily creatinine excretion in the urine of normal and dystrophic mice was determined and then the carcass proteins were quantitatively extracted into soluble, myofibrillar and collagenous fractions. 2. on a live body-weight basis, total carcass protein was 15% lower in dystrophic than in normal mice. Relative to carcass weight, however, the amount of protein was significantly lower only in male dystrophic mice. 3. the myofibrillar protein fraction comprised 36.3 and 32.5% of the total protein in male and female dystrophic mice and 48.8 and 45.0% respectively in normal mice. the decrease in myofibrillar protein in dystrophic mice was accompanied by an increase in the residual collagenous fraction of proteins. 4. the rate of excretion of creatinine was strongly correlated (r = +0.98) with the myofibrillar protein mass in each mouse. This relationship was the same for both normal and dystrophic mice, each gram of myofibrillar protein being associated with 3.6 μmol of creatinine excreted/day. 5. the creatinine excretion rate is a valid index of contractile muscle mass in murine dystrophy.

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