scholarly journals Complementary Biomarker Assessment of Components Absorbed from Diet and Creatinine Excretion Rate Reflecting Muscle Mass in Dialysis Patients

Nutrients ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1827 ◽  
Author(s):  
Adrian Post ◽  
Akin Ozyilmaz ◽  
Ralf Westerhuis ◽  
Karin Ipema ◽  
Stephan Bakker ◽  
...  
Keyword(s):  
Dietary Intake ◽  
Muscle Mass ◽  
Protein Intake ◽  
Excretion Rate ◽  
Protein Energy Malnutrition ◽  
Dialysis Patients ◽  
Sodium Potassium ◽  
Waste Products ◽  
Creatinine Excretion ◽  
Creatinine Excretion Rate

To prevent protein energy malnutrition (PEM) and accumulation of waste products, dialysis patients require diet adjustments. Dietary intake assessed by self-reported intakes often provides biased information and standard 24-h urinary excretion is inapplicable in dialysis patients. We aimed to assess dietary intake via a complementary, less biased biomarker method, and to compare this to dietary diaries. Additionally, we investigated the prospective association of creatinine excretion rate (CER) reflecting muscle mass with mortality. Complete intradialytic dialysate and interdialytic urinary collections were used to calculate 24-h excretion of protein, sodium, potassium, phosphate and creatinine in 42 chronic dialysis patients and compared with protein, sodium, potassium, and phosphate intake assessed by 5-day dietary diaries. Cox regression analyses were employed to investigate associations of CER with mortality. Mean age was 64 ± 13 years and 52% were male. Complementary biomarker assessed (CBA) and dietary assessed (DA) protein intake were significantly correlated (r = 0.610; p < 0.001), but there was a constant bias, as dietary diaries overestimated protein intake in most patients. Correlations were found between CBA and DA sodium intake (r = 0.297; p = 0.056), potassium intake (r = 0.312; p = 0.047) and phosphate uptake/intake (r = 0.409; p = 0.008). However, Bland-Altman analysis showed significant proportional bias. During a median follow-up of 26.6 (25.3–31.5) months, nine dialysis patients (23%) died. CER was independently and inversely associated with survival (HR: 0.59 (0.42–0.84); p = 0.003). Excretion measurements may be a more reliable assessment of dietary intake in dialysis patients, as this method is relatively free from biases known to exist for self-reported intakes. CER seems to be a promising tool for monitoring PEM.

Creatinine excretion rate, a marker of muscle mass, is related to clinical outcome in patients with chronic systolic heart failure

2014 ◽  
Vol 103 (12) ◽  
pp. 976-983 ◽  
Author(s):  
Jozine M. ter Maaten ◽  
Kevin Damman ◽  
Hans L. Hillege ◽  
Stephan J. Bakker ◽  
Stefan D. Anker ◽  
...  
Keyword(s):  
Heart Failure ◽  
Clinical Outcome ◽  
Muscle Mass ◽  
Excretion Rate ◽  
Systolic Heart Failure ◽  
Creatinine Excretion ◽  
Chronic Systolic Heart Failure ◽  
Creatinine Excretion Rate

Excretion trends in men undergoing deacclimatization to heat

1962 ◽  
Vol 17 (3) ◽  
pp. 456-460
Author(s):  
Henry B. Hale ◽  
James P. Ellis ◽  
Bruno Balke ◽  
Richard C. McNee
Keyword(s):  
Uric Acid ◽  
Transition Period ◽  
Excretion Rate ◽  
Potassium Phosphate ◽  
Creatinine Ratio ◽  
Heat Acclimatization ◽  
Sodium Potassium ◽  
Creatinine Excretion ◽  
Phosphate Excretion ◽  
Creatinine Excretion Rate

In an effort to characterize metabolic changes associated with heat deacclimatization under natural conditions, urinary determinations were made on 21 healthy men during the transition period from summer to fall. Two overnight urine specimens per subject per week were analyzed for sodium, potassium, phosphate, urea, uric acid, creatinine, and 17-hydroxycorticosteroids (17-OHCS). No trends were found for urine output, uric acid, urea, or sodium. Creatinine excretion rate and Na/K ratio fell as environmental temperature fell; potassium/creatinine ratio and potassium excretion rate increased. These four variables showed linear trends, but phosphate/creatinine ratio increased in a stepwise manner and urea/creatinine ratio increased only after temperature had fallen far below the summer level. Excretion of 17-OHCS (as rate or ratio) declined (two-stage shift). Subjects who did not exercise regularly showed upward shifting in phosphate excretion; nonexercising subjects as a group showed a cyclic tendency; and those who exercised daily showed essentially no change in phosphate excretion. This retention of one summer characteristic in the latter group is consonant with the literature on heat acclimatization in that it shows that physical fitness is a factor that delays heat deacclimatization. Submitted on May 25, 1961

scholarly journals Posttransplant muscle mass measured by urinary creatinine excretion rate predicts long-term outcomes after liver transplantation

2018 ◽  
Vol 19 (2) ◽  
pp. 540-550 ◽  
Author(s):  
Suzanne P. Stam ◽  
Maryse C. J. Osté ◽  
Michele F. Eisenga ◽  
Hans Blokzijl ◽  
Aad P. van den Berg ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Muscle Mass ◽  
Excretion Rate ◽  
Long Term Outcomes ◽  
Creatinine Excretion ◽  
Urinary Creatinine ◽  
Urinary Creatinine Excretion ◽  
Creatinine Excretion Rate

scholarly journals Variability of Urinary Creatinine in Healthy Individuals

2021 ◽  
Vol 18 (6) ◽  
pp. 3166
Author(s):  
Gerd Sallsten ◽  
Lars Barregard
Keyword(s):  
Flow Rate ◽  
Excretion Rate ◽  
Time Of Day ◽  
Urinary Flow Rate ◽  
Urinary Flow ◽  
Diurnal Variability ◽  
Creatinine Excretion ◽  
Blood Samples ◽  
Urinary Creatinine ◽  
Creatinine Excretion Rate

Many urinary biomarkers are adjusted for dilution using creatinine or specific gravity. The aim was to evaluate the variability of creatinine excretion, in 24 h and spot samples, and to describe an openly available variability biobank. Urine and blood samples were collected from 60 healthy non-smoking adults, 29 men and 31 women. All urine was collected at six time points during two 24 h periods. Blood samples were also collected twice and stored frozen. Analyses of creatinine in urine was performed in fresh urine using an enzymatic method. For creatinine in urine, the intra-class correlation (ICC) was calculated for 24 h urine and spot samples. Diurnal variability was examined, as well as association with urinary flow rate. The creatinine excretion rate was lowest in overnight samples and relatively constant in the other five samples. The creatinine excretion rate in each individual was positively correlated with urinary flow rate. The creatinine concentration was highest in the overnight sample and at 09:30. For 24 h samples the ICC was 0.64, for overnight samples it was 0.5, and for all spot samples, it was much lower. The ICC for urinary creatinine depends on the time of day of sampling. Frozen samples from this variability biobank are open for researchers examining normal variability of their favorite biomarker(s).

scholarly journals Creatinine Excretion Rate and Mortality in Type 2 Diabetes and Nephropathy

Diabetes Care ◽  
2013 ◽  
Vol 36 (6) ◽  
pp. 1489-1494 ◽  
Author(s):  
S. J. Sinkeler ◽  
A. J. Kwakernaak ◽  
S. J. L. Bakker ◽  
S. Shahinfar ◽  
E. Esmatjes ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Excretion Rate ◽  
Creatinine Excretion ◽  
Creatinine Excretion Rate
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