scholarly journals RBP4 Gene

2020 ◽  
Author(s):  
Keyword(s):  
Rbp4 Gene

Ontogenic expression pattern and genetic polymorphisms of the retinol-binding protein 4 (RBP4) gene in Erlang mountainous chickens

Gene ◽  
2013 ◽  
Vol 526 (2) ◽  
pp. 170-175 ◽  
Author(s):  
Hua-Dong Yin ◽  
Elizabeth R. Gilbert ◽  
Shi-Yi Chen ◽  
Di-Yan Li ◽  
Zhi-Chao Zhang ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Expression Pattern ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Retinol Binding Protein 4 ◽  
Ontogenic Expression ◽  
Rbp4 Gene

scholarly journals Association of RBP4 Genotype with Phenotypic Reproductive Traits of Sows

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
A. Marantidis ◽  
G. P. Laliotis ◽  
M. Avdi
Keyword(s):  
Litter Size ◽  
Negative Impact ◽  
Reproductive Traits ◽  
Retinol Binding Protein ◽  
Rapid Improvement ◽  
Retinol Binding Protein 4 ◽  
Reproductive Characteristics ◽  
Pcr Rflp ◽  
Hardy Weinberg Equilibrium ◽  
Rbp4 Gene

PCR-RFLP was applied to a commercial crossbred pig population in order to investigate the association between polymorphism (SNP) of Retinol-binding protein 4 (RBP4) gene and reproductive performance. 400 sows were genotyped and 2000 records of reproductive traits were used in order to retrieve information about the allele frequencies and the association of the RBP4 gene with main reproductive characteristics of the population. A deviation from the Hardy-Weinberg equilibrium was observed as a result of the AB genotype excess. In addition, the AA genotype saw statistically significant higher values of (i) the total number of born piglets (p<0.05), (ii) the number of piglets born alive (p<0.01), and (iii) the number of weaned piglets (p<0.01). The number of the mummified piglets and the number of the piglets born dead did not differ between the various RBP4 genotypes. Interestingly, the AA genotype had a negative impact (p<0.05) on the number of piglets born dead, resulting indirectly in a larger litter size. In conclusion, the AA genotype and in extension the A allele of RBP4 gene are in favor of producing larger litter size, suggesting that the RBP4 gene may be used in Marker-Assisted Selection (MAS) programs for a rapid improvement of the reproductive characteristics in pigs.

scholarly journals Peroxisome Proliferator-Activated Receptors-α and -γ, and cAMP-Mediated Pathways, Control Retinol-Binding Protein-4 Gene Expression in Brown Adipose Tissue

Endocrinology ◽  
2012 ◽  
Vol 153 (3) ◽  
pp. 1162-1173 ◽  
Author(s):  
Meritxell Rosell ◽  
Elayne Hondares ◽  
Sadahiko Iwamoto ◽  
Frank J. Gonzalez ◽  
Martin Wabitsch ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Retinol Binding Protein ◽  
Peroxisome Proliferator ◽  
Brown Adipocytes ◽  
Retinol Binding Protein 4 ◽  
White Adipocytes ◽  
Brown Adipose ◽  
Rbp4 Gene

Retinol binding protein-4 (RBP4) is a serum protein involved in the transport of vitamin A. It is known to be produced by the liver and white adipose tissue. RBP4 release by white fat has been proposed to induce insulin resistance. We analyzed the regulation and production of RBP4 in brown adipose tissue. RBP4 gene expression is induced in brown fat from mice exposed to cold or treated with peroxisome proliferator-activated receptor (PPAR) agonists. In brown adipocytes in culture, norepinephrine, cAMP, and activators of PPARγ and PPARα induced RBP4 gene expression and RBP4 protein release. The induction of RBP4 gene expression by norepinephrine required intact PPAR-dependent pathways, as evidenced by impaired response of the RBP4 gene expression to norepinephrine in PPARα-null brown adipocytes or in the presence of inhibitors of PPARγ and PPARα. PPARγ and norepinephrine can also induce the RBP4 gene in white adipocytes, and overexpression of PPARα confers regulation by this PPAR subtype to white adipocytes. The RBP4 gene promoter transcription is activated by cAMP, PPARα, and PPARγ. This is mediated by a PPAR-responsive element capable of binding PPARα and PPARγ and required also for activation by cAMP. The induction of the RBP4 gene expression by norepinephrine in brown adipocytes is protein synthesis dependent and requires PPARγ-coactivator-1-α, which acts as a norepinephine-induced coactivator of PPAR on the RBP4 gene. We conclude that PPARγ- and PPARα-mediated signaling controls RBP4 gene expression and releases in brown adipose tissue, and thermogenic activation induces RBP4 gene expression in brown fat through mechanisms involving PPARγ-coactivator-1-α coactivation of PPAR signaling.

Linkage mapping of the retinol-binding protein 4 (RBP4) gene to porcine Chromosome 14

1996 ◽  
Vol 7 (5) ◽  
pp. 396-396 ◽  
Author(s):  
L. A. Messer ◽  
L. Wang ◽  
J. Yelich ◽  
D. Pomp ◽  
R. D. Geisert ◽  
...  
Keyword(s):  
Linkage Mapping ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Porcine Chromosome ◽  
Chromosome 14 ◽  
Retinol Binding Protein 4 ◽  
Rbp4 Gene

Investigation of the retinol-binding protein 4 (RBP4) gene as a candidate gene for increased litter size in pigs

2000 ◽  
Vol 11 (1) ◽  
pp. 75-77 ◽  
Author(s):  
Max F. Rothschild ◽  
Lori Messer ◽  
Andy Day ◽  
Richard Wales ◽  
Tom Short ◽  
...  
Keyword(s):  
Candidate Gene ◽  
Litter Size ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Retinol Binding Protein 4 ◽  
Rbp4 Gene

scholarly journals Regulatory SNP in the RBP4 Gene Modified the Expression in Adipocytes and Associated With BMI

Obesity ◽  
2010 ◽  
Vol 18 (5) ◽  
pp. 1006-1014 ◽  
Author(s):  
Lkhagvasuren Munkhtulga ◽  
Shuichi Nagashima ◽  
Kazuhiro Nakayama ◽  
Nanami Utsumi ◽  
Yoshiko Yanagisawa ◽  
...  
Keyword(s):  
Rbp4 Gene
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