Investigation of the retinol-binding protein 4 (RBP4) gene as a candidate gene for increased litter size in pigs

2000 ◽  
Vol 11 (1) ◽  
pp. 75-77 ◽  
Author(s):  
Max F. Rothschild ◽  
Lori Messer ◽  
Andy Day ◽  
Richard Wales ◽  
Tom Short ◽  
...  
Keyword(s):  
Candidate Gene ◽  
Litter Size ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Retinol Binding Protein 4 ◽  
Rbp4 Gene

Ontogenic expression pattern and genetic polymorphisms of the retinol-binding protein 4 (RBP4) gene in Erlang mountainous chickens

Gene ◽  
2013 ◽  
Vol 526 (2) ◽  
pp. 170-175 ◽  
Author(s):  
Hua-Dong Yin ◽  
Elizabeth R. Gilbert ◽  
Shi-Yi Chen ◽  
Di-Yan Li ◽  
Zhi-Chao Zhang ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Expression Pattern ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Retinol Binding Protein 4 ◽  
Ontogenic Expression ◽  
Rbp4 Gene

scholarly journals Association of RBP4 Genotype with Phenotypic Reproductive Traits of Sows

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
A. Marantidis ◽  
G. P. Laliotis ◽  
M. Avdi
Keyword(s):  
Litter Size ◽  
Negative Impact ◽  
Reproductive Traits ◽  
Retinol Binding Protein ◽  
Rapid Improvement ◽  
Retinol Binding Protein 4 ◽  
Reproductive Characteristics ◽  
Pcr Rflp ◽  
Hardy Weinberg Equilibrium ◽  
Rbp4 Gene

PCR-RFLP was applied to a commercial crossbred pig population in order to investigate the association between polymorphism (SNP) of Retinol-binding protein 4 (RBP4) gene and reproductive performance. 400 sows were genotyped and 2000 records of reproductive traits were used in order to retrieve information about the allele frequencies and the association of the RBP4 gene with main reproductive characteristics of the population. A deviation from the Hardy-Weinberg equilibrium was observed as a result of the AB genotype excess. In addition, the AA genotype saw statistically significant higher values of (i) the total number of born piglets (p<0.05), (ii) the number of piglets born alive (p<0.01), and (iii) the number of weaned piglets (p<0.01). The number of the mummified piglets and the number of the piglets born dead did not differ between the various RBP4 genotypes. Interestingly, the AA genotype had a negative impact (p<0.05) on the number of piglets born dead, resulting indirectly in a larger litter size. In conclusion, the AA genotype and in extension the A allele of RBP4 gene are in favor of producing larger litter size, suggesting that the RBP4 gene may be used in Marker-Assisted Selection (MAS) programs for a rapid improvement of the reproductive characteristics in pigs.

Linkage mapping of the retinol-binding protein 4 (RBP4) gene to porcine Chromosome 14

1996 ◽  
Vol 7 (5) ◽  
pp. 396-396 ◽  
Author(s):  
L. A. Messer ◽  
L. Wang ◽  
J. Yelich ◽  
D. Pomp ◽  
R. D. Geisert ◽  
...  
Keyword(s):  
Linkage Mapping ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Porcine Chromosome ◽  
Chromosome 14 ◽  
Retinol Binding Protein 4 ◽  
Rbp4 Gene

The Retinol Binding Protein-4 (RBP4) Gene and Gestational Diabetes

2017 ◽  
pp. 135-145
Author(s):  
Renata Saucedo ◽  
Jorge Valencia ◽  
Lourdes Basurto ◽  
Marcelino Hernandez ◽  
Edgardo Puello ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Retinol Binding Protein 4 ◽  
Rbp4 Gene

scholarly journals Plasma retinol-binding protein 4 in the first and second trimester and risk of gestational diabetes mellitus in Chinese women: a nested case-control study

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Chuyao Jin ◽  
Lizi Lin ◽  
Na Han ◽  
Zhiling Zhao ◽  
Zheng Liu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Binding Protein ◽  
First Trimester ◽  
Retinol Binding Protein ◽  
Second Trimester ◽  
Retinol Binding Protein 4 ◽  
Plasma Retinol

Abstract Background To assess the association between plasma retinol-binding protein 4 (RBP4) levels both in the first trimester and second trimester and risk of gestational diabetes mellitus (GDM). Methods Plasma RBP4 levels and insulin were measured among 135 GDM cases and 135 controls nested within the Peking University Birth Cohort in Tongzhou. Multivariable linear regression analysis was conducted to assess the influence of RBP4 levels on insulin resistance. Conditional logistic regression models were used to compute the odds ratio (OR) and 95% confidence interval (CI) between RBP4 levels and risk of GDM. Results The GDM cases had significantly higher levels of RBP4 in the first trimester than controls (medians: 18.0 μg/L vs 14.4 μg/L; P < 0.05). Plasma RBP4 concentrations in the first and second trimester were associated with fasting insulin, homeostasis model assessment for insulin resistance (HOMA-IR), and the quantitative insulin sensitivity check index (QUICKI) in the second trimester (all P < 0.001). With adjustment for diet, physical activity, and other risk factors for GDM, the risk of GDM increased with every 1-log μg/L increment of RBP4 levels, and the OR (95% CI) was 3.12 (1.08–9.04) for RBP4 in the first trimester and 3.38 (1.03–11.08) for RBP4 in the second trimester. Conclusions Plasma RBP4 levels both in the first trimester and second trimester were dose-dependently associated with increased risk of GDM.

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