scholarly journals Recent Thymic Emigrant

2020 ◽  
Author(s):  
Keyword(s):  
Recent Thymic Emigrant

scholarly journals Levels of Recent Thymic Emigrant Cells Decrease in Children Undergoing Partial Thymectomy during Cardiac Surgery

2005 ◽  
Vol 12 (5) ◽  
pp. 563-565 ◽  
Author(s):  
Ashish B. Madhok ◽  
A. Chandrasekran ◽  
Vincent Parnell ◽  
Mysore Gandhi ◽  
Devyani Chowdhury ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
T Cell ◽  
Postoperative Period ◽  
Real Time Pcr ◽  
Peripheral Blood Lymphocytes ◽  
Fetal Life ◽  
Significant Drop ◽  
Recent Thymic Emigrant ◽  
Cell Pool

ABSTRACT The human thymus is required for establishment of a T-cell pool in fetal life, but postnatal thymectomy is not known to cause immunodeficiency. T-cell emigration from thymus (thymic recent emigrants [TRECs]) is a continuous thymic-dependent process. We studied TREC levels pre- and post-partial thymectomy in children undergoing cardiac surgery. TRECs were quantitated by real-time PCR in peripheral blood lymphocytes of 24 children (0 to 12 years). TREC values were 47916 ± 9271 pre-partial thymectomy and 33157 ± 8479 post-partial thymectomy in 11 paired patients (P = 0.014). Interval between pre- and post-partial thymectomy was 8.8 days ± 5.8 days. Another group of 8 children had 30384 ± 9748 TRECs 16 days to 6 years post-partial thymectomy. There was a significant drop in TREC values post-partial thymectomy in the immediate postoperative period compared to prethymectomy TREC levels. While decreased thymic output may persist, the long-term implications were not evaluated in this patient population.

scholarly journals Unstable regulatory T cells, enriched for naïve and Nrp1neg cells, are purged after fate challenge

2021 ◽  
Vol 6 (61) ◽  
pp. eabe4723
Author(s):  
Steffie Junius ◽  
Adamantios V. Mavrogiannis ◽  
Pierre Lemaitre ◽  
Margaux Gerbaux ◽  
Frederik Staels ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Complex Mixture ◽  
Recent Thymic Emigrant ◽  
Effector T Cell ◽  
Neuropilin 1 ◽  
Mapping System ◽  
A Cell ◽  
Clinical Potential ◽  
Secondary Stability

Regulatory T cells (Tregs) are indispensable for the control of immune homeostasis and have clinical potential as a cell therapy for treating autoimmunity. Tregs can lose expression of the lineage-defining Foxp3 transcription factor and acquire effector T cell (Teff) characteristics, a process referred to as Treg plasticity. The extent and reversibility of such plasticity during immune responses remain unknown. Here, using a murine genetic fate-mapping system, we show that Treg stability is maintained even during exposure to a complex microbial/antigenic environment. Furthermore, we demonstrate that the observed plasticity of Tregs after adoptive transfer into a lymphopenic environment is a property limited to only a subset of the Treg population, with the nonconverting majority of Tregs being resistant to plasticity upon secondary stability challenge. The unstable Treg fraction is a complex mixture of phenotypically distinct Tregs, enriched for naïve and neuropilin-1–negative Tregs, and includes peripherally induced Tregs and recent thymic emigrant Tregs. These results suggest that a “purging” process can be used to purify stable Tregs that are capable of robust fate retention, with potential implications for improving cell transfer therapy.

Rôle et importance des lymphocytes RTE (recent thymic emigrant) dans la réponse immunitaire anti-gliome: résultats préliminaires

2007 ◽  
Vol 53 (5) ◽  
pp. 425-426
Author(s):  
E. Jouanneau ◽  
L. Veiga ◽  
K.L. Black ◽  
Y. Zhai ◽  
X.-X. Zhang ◽  
...  
Keyword(s):  
Recent Thymic Emigrant

Short Communication: Naive CD4+ T Cells and Recent Thymic Emigrant Levels in Treated Individuals with HIV: Clinical Relevance

2006 ◽  
Vol 22 (9) ◽  
pp. 893-896 ◽  
Author(s):  
Margarita Bofill ◽  
Javier Martinez-Picado ◽  
Raul Ruiz-Hernandez ◽  
Cecilia Cabrera ◽  
Silvia Marfil ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Clinical Relevance ◽  
Short Communication ◽  
Recent Thymic Emigrant

scholarly journals Identification of a human recent thymic emigrant phenotype

2000 ◽  
Vol 97 (8) ◽  
pp. 4215-4220 ◽  
Author(s):  
R. D. McFarland ◽  
D. C. Douek ◽  
R. A. Koup ◽  
L. J. Picker
Keyword(s):  
Recent Thymic Emigrant

Thymic function and output of recent thymic emigrant T cells during intracranial glioma progression

2003 ◽  
Vol 64 (1-2) ◽  
pp. 45-54 ◽  
Author(s):  
Robert M. Prins ◽  
Martin R. Graf ◽  
Randall E. Merchant ◽  
Keith L. Black ◽  
Christopher J. Wheeler
Keyword(s):  
T Cells ◽  
Thymic Function ◽  
Recent Thymic Emigrant ◽  
Glioma Progression
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