Orbital Part of the Inferior Frontal Gyrus

Altered functional connectivity of the nucleus accumbens subdivisions in amphetamine-type stimulant abusers: a resting-state fMRI study

BMC Neuroscience ◽

10.1186/s12868-019-0548-y ◽

2019 ◽

Vol 20 (1) ◽

Cited By ~ 1

Author(s):

Yun Wang ◽

Kai-Juan Yan ◽

Chen-Xiao Fan ◽

Xiao-Nian Luo ◽

Yuan Zhou

Keyword(s):

Nucleus Accumbens ◽

Functional Connectivity ◽

Resting State ◽

Inferior Frontal Gyrus ◽

Resting State Fmri ◽

Resting State Functional Connectivity ◽

Functional Architecture ◽

Superior Frontal Gyrus ◽

Eyes Closed ◽

Orbital Part

Abstract Background The growing abuse of amphetamine-type stimulants leads to new challenges to human health. A possible addiction mechanism has been proposed by altered functional architecture of the nucleus accumbens (NAc) during resting state. NAc contains different subdivisions and they may play different roles in addiction. The aim of the present study was to examine whether there are common or distinct patterns of functional connectivity of the NAc subdivisions in amphetamine-type stimulant abusers (ATSAs). Methods The present study recruited 17 male ATSAs and 22 healthy male controls. All the subjects underwent resting-state functional magnetic resonance imaging (fMRI) with their eyes closed. The NAc was divided into core-like and shell-like subdivisions. We used seed-based resting-state functional connectivity (RSFC) analyses to identify differences in brain functional architecture between ATSAs and healthy controls (HCs). Results ATSAs had lower positive RSFCs with all of the NAc subdivisions over the left orbital part of superior frontal gyrus and higher positive RSFCs with the NAc subdivisions over the left opercular part of inferior frontal gyrus than HCs, which indicates common abnormalities across the NAc subdivisions in ATSAs. In addition, the RSFCs between the NAc subdivisions and the left orbital part of superior frontal gyrus were negatively correlated with the addiction severity in ATSAs. Conclusion These results provide evidence that there are common RSFC patterns of the NAc subdivisions in ATSAs. The abnormality indicated by disrupted functional connectivity between the NAc subdivisions and prefrontal cortex suggests abnormal interaction between the rewarding process and cognitive control in ATSAs. Our results shed insight on the neurobiological mechanisms of ATSA and suggest potential novel therapeutic targets for treatment and intervention of ATSAs.

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Specific Gray Matter Volume Changes of the Brain in Unipolar and Bipolar Depression

Frontiers in Human Neuroscience ◽

10.3389/fnhum.2020.592419 ◽

2021 ◽

Vol 14 ◽

Author(s):

Junyan Wang ◽

Penghong Liu ◽

Aixia Zhang ◽

Chunxia Yang ◽

Sha Liu ◽

...

Keyword(s):

Gray Matter ◽

Bipolar Depression ◽

Inferior Frontal Gyrus ◽

Gray Matter Volume ◽

Structural Basis ◽

Middle Temporal Gyrus ◽

Healthy Controls ◽

Matter Volume ◽

The Common ◽

Orbital Part

To identify the common and specific structural basis of bipolar depression (BD) and unipolar depression (UD) is crucial for clinical diagnosis. In this study, a total of 85 participants, including 22 BD patients, 36 UD patients, and 27 healthy controls, were enrolled. A voxel-based morphology method was used to identify the common and specific changes of the gray matter volume (GMV) to determine the structural basis. Significant differences in GMV were found among the three groups. Compared with healthy controls, UD patients showed decreased GMV in the orbital part of the left inferior frontal gyrus, whereas BD patients showed decreased GMV in the orbital part of the left middle frontal gyrus. Compared with BD, UD patients have increased GMV in the left supramarginal gyrus and middle temporal gyrus. Our results revealed different structural changes in UD and BD patients suggesting BD and UD have different neurophysiological underpinnings. Our study contributes toward the biological determination of morphometric changes, which could help to discriminate between UD and BD.

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Local Functional MR Change Pattern and Its Association With Cognitive Function in Objectively-Defined Subtle Cognitive Decline

Frontiers in Aging Neuroscience ◽

10.3389/fnagi.2021.684918 ◽

2021 ◽

Vol 13 ◽

Author(s):

Liang Cui ◽

Zhen Zhang ◽

Chun-Yi Zac Lo ◽

Qihao Guo

Keyword(s):

Cognitive Decline ◽

Functional Activity ◽

Mmse Score ◽

Inferior Frontal Gyrus ◽

Brain Regions ◽

Amci Group ◽

Local Functional ◽

Middle Occipital Gyrus ◽

The Right ◽

Orbital Part

Introduction: To identify individuals with preclinical cognitive impairment, researchers proposed the concept of objectively-defined subtle cognitive decline (Obj-SCD). However, it is not clear whether Obj-SCD has characteristic brain function changes. In this study, we aimed at exploring the changing pattern of brain function activity in Obj-SCD individuals and the similarities and differences with mild cognitive impairments (MCI).Method: 37 healthy control individuals, 25 Obj-SCD individuals (with the impairment in memory and language domain), and 28 aMCI individuals were included. Resting-state fMRI and neuropsychological tests were performed. fALFF was used to reflect the local functional activity and compared between groups. Finally, we analyzed the correlation between the fALFF values of significantly changed regions and neuropsychological performance.Results: We found similar functional activity enhancements in some local brain regions in the Obj-SCD and aMCI groups, including the left orbital part of the inferior frontal gyrus and the left median cingulate and paracingulate gyri. However, some changes in local functional activities of the Obj-SCD group showed different patterns from the aMCI group. Compared with healthy control (HC), the Obj-SCD group showed increased local functional activity in the right middle occipital gyrus, decreased local functional activity in the left precuneus and the left inferior temporal gyrus. In the Obj-SCD group, in normal band, the fALFF value of the right middle occipital gyrus was significantly negatively correlated with Mini-Mental State Examination (MMSE) score (r = −0.450, p = 0.024) and Animal Verbal Fluency Test (AFT) score (r = −0.402, p = 0.046); the left inferior temporal gyrus was significantly positively correlated with MMSE score (r = 0.588, p = 0.002). In slow-4 band, the fALFF value of the left precuneus was significantly positively correlated with MMSE score (r = 0.468, p = 0.018) and AFT score (r = 0.600, p = 0.002). In the aMCI group, the fALFF value of the left orbital part of the inferior frontal gyrus was significantly positively correlated with Auditory Verbal Learning Test (AVLT) long delay cued recall score (r = 0.506, p = 0.006).Conclusion: The Obj-SCD group showed a unique changing pattern; the functional changes of different brain regions have a close but different correlation with cognitive impairment, indicating that there may be a complex pathological basis inside. This suggests that Obj-SCD may be a separate stage of cognitive decline before aMCI and is helpful to the study of preclinical cognitive decline.

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Effect of the SIRT1 gene on regional cortical grey matter density in the Han Chinese population

The British Journal of Psychiatry ◽

10.1192/bjp.2018.270 ◽

2018 ◽

Vol 216 (5) ◽

pp. 254-258 ◽

Cited By ~ 2

Author(s):

Shuquan Rao ◽

Na Luo ◽

Jing Sui ◽

Qi Xu ◽

Fuquan Zhang

Keyword(s):

Chinese Population ◽

Grey Matter ◽

Inferior Frontal Gyrus ◽

Matter Density ◽

Han Chinese ◽

Pathophysiological Mechanism ◽

Han Chinese Population ◽

Grey Matter Density ◽

Genome Wide ◽

Orbital Part

BackgroundOur previous genome-wide association study (CONVERGE sample) identified significant association between single nucleotide polymorphisms (SNPs) near the SIRT1 gene and major depressive disorder (MDD) in Chinese populations.AimsTo investigate whether SNPs across the SIRT1 gene locus affect regional grey matter density in the Han Chinese population.MethodT1-weighted structural magnetic resonance imaging was conducted on 92 healthy participants from Eastern China. Grey matter was segmented from the image, which consisted of voxel-wise grey matter density. The effect of SIRT1 SNPs on grey matter density was determined by a multiple linear regression framework.ResultsSNP rs4746720 was significantly associated with grey matter density in two brain cortical regions: the orbital part of the right inferior frontal gyrus and the orbital part of the left inferior frontal gyrus (family-wise error-corrected P < 0.05; voxel-wise P < 0.001). Also, rs4746720 exceeded genome-wide significance in association with MDD in our CONVERGE sample (P = 3.32 × 10−08, odds ratio 1.161).ConclusionsOur results provided evidence for a potential role of the SIRT1 gene in the brain, implying a possible pathophysiological mechanism underlying susceptibility to MDD.

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Contribution of Inflammation and Hypoperfusion to White Matter Hyperintensities-Related Cognitive Impairment

Frontiers in Neurology ◽

10.3389/fneur.2021.786840 ◽

2022 ◽

Vol 12 ◽

Author(s):

Chao-Juan Huang ◽

Xia Zhou ◽

Xin Yuan ◽

Wei Zhang ◽

Ming-Xu Li ◽

...

Keyword(s):

Cognitive Impairment ◽

White Matter ◽

White Matter Hyperintensities ◽

Small Vessel Disease ◽

Inferior Frontal Gyrus ◽

Multivariate Logistic Regression Analysis ◽

Middle Temporal Gyrus ◽

Whole Brain ◽

Triangular Part ◽

Orbital Part

White matter hyperintensities (WMHs) of presumed vascular origin are one of the most important neuroimaging markers of cerebral small vessel disease (CSVD), which are closely associated with cognitive impairment. The aim of this study was to elucidate the pathogenesis of WMHs from the perspective of inflammation and hypoperfusion mechanisms. A total of 65 patients with WMHs and 65 healthy controls were enrolled in this study. Inflammatory markers measurements [hypersensitive C-reactive protein (hsCRP) and lipoprotein-associated phospholipase A2 (Lp-PLA2)], cognitive evaluation, and pseudocontinuous arterial spin labeling (PCASL) MRI scanning were performed in all the subjects. The multivariate logistic regression analysis showed that Lp-PLA2 was an independent risk factor for WMHs. Cerebral blood flow (CBF) in the whole brain, gray matter (GM), white matter (WM), left orbital medial frontal gyrus [MFG.L (orbital part)], left middle temporal gyrus (MTG.L), and right thalamus (Tha.R) in the patients was lower than those in the controls and CBF in the left triangular inferior frontal gyrus [IFG.L (triangular part)] was higher in the patients than in the controls. There was a significant correlation between Lp-PLA2 levels and CBF in the whole brain (R = −0.417, p < 0.001) and GM (R = −0.278, p = 0.025), but not in the WM in the patients. Moreover, CBF in the MFG.L (orbital part) and the Tha.R was, respectively, negatively associated with the trail making test (TMT) and the Stroop color word test (SCWT), suggesting the higher CBF, the better executive function. The CBF in the IFG.L (triangular part) was negatively correlated with attention scores in the Cambridge Cognitive Examination-Chinese Version (CAMCOG-C) subitems (R = −0.288, p = 0.020). Our results revealed the vascular inflammation roles in WMHs, which may through the regulation of CBF in the whole brain and GM. Additionally, CBF changes in different brain regions may imply a potential role in the modulation of cognitive function in different domains.

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Configural memory of a blending aromatic mixture reflected in activation of the left orbital part of the inferior frontal gyrus

Behavioural Brain Research ◽

10.1016/j.bbr.2020.113088 ◽

2021 ◽

Vol 402 ◽

pp. 113088

Author(s):

C. Sinding ◽

T. Hummel ◽

N. Béno ◽

J. Prescott ◽

M. Bensafi ◽

...

Keyword(s):

Inferior Frontal Gyrus ◽

Orbital Part

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Dysfunction of Affective Network in Post Ischemic Stroke Depression: A Resting-State Functional Magnetic Resonance Imaging Study

BioMed Research International ◽

10.1155/2014/846830 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 8

Author(s):

Peiyao Zhang ◽

Qin Xu ◽

Jianping Dai ◽

Jun Wang ◽

Ning Zhang ◽

...

Keyword(s):

Resting State ◽

Hamilton Depression Rate Scale ◽

Inferior Frontal Gyrus ◽

Imaging Study ◽

Magnetic Resonance Imaging Study ◽

Functional Magnetic Resonance ◽

Resonance Imaging ◽

Stroke Patients ◽

Orbital Part ◽

Normal Controls

Objective. Previous studies have demonstrated that stroke characteristics and social and psychological factors jointly contribute to the development of poststroke depression (PSD). The purpose of this study was to identify altered functional connectivity (FC) of the affective network (AN) in patients with PSD and to explore the correlation between FC and the severity of PSD.Materials and Methods. 26 PSD patients, 24 stroke patients without depression, and 24 age-matched normal controls underwent the resting-state functional MRI (fMRI) scanning. The bilateral anterior cingulated cortices (ACCs) were selected as regions of interest (ROIs). FC was calculated and compared among the three groups. The association between FC and Hamilton Depression Rate Scale (HDRS) scores of PSD group was investigated.Results. The FC of the AN was disrupted in PSD patients compared to stroke patients without depression and normal controls. Moreover, the left orbital part of inferior frontal gyrus which indicated altered FC was significantly correlated with HDRS scores in PSD patients.Conclusions. Dysfunction of the affective network may be one of the reasons of the development of PSD.

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When Hearing Does Not Mean Understanding: On the Neural Processing of Syntactically Complex Sentences by Listeners With Hearing Loss

Journal of Speech Language and Hearing Research ◽

10.1044/2020_jslhr-20-00262 ◽

2021 ◽

pp. 1-13

Author(s):

Margreet Vogelzang ◽

Christiane M. Thiel ◽

Stephanie Rosemann ◽

Jochem W. Rieger ◽

Esther Ruigendijk

Keyword(s):

Hearing Loss ◽

Sentence Processing ◽

Secondary Task ◽

Sentence Comprehension ◽

Inferior Frontal Gyrus ◽

Normal Hearing ◽

Cognitive Demands ◽

Sentence Complexity ◽

Complex Sentences ◽

And Task

Purpose Adults with mild-to-moderate age-related hearing loss typically exhibit issues with speech understanding, but their processing of syntactically complex sentences is not well understood. We test the hypothesis that listeners with hearing loss' difficulties with comprehension and processing of syntactically complex sentences are due to the processing of degraded input interfering with the successful processing of complex sentences. Method We performed a neuroimaging study with a sentence comprehension task, varying sentence complexity (through subject–object order and verb–arguments order) and cognitive demands (presence or absence of a secondary task) within subjects. Groups of older subjects with hearing loss ( n = 20) and age-matched normal-hearing controls ( n = 20) were tested. Results The comprehension data show effects of syntactic complexity and hearing ability, with normal-hearing controls outperforming listeners with hearing loss, seemingly more so on syntactically complex sentences. The secondary task did not influence off-line comprehension. The imaging data show effects of group, sentence complexity, and task, with listeners with hearing loss showing decreased activation in typical speech processing areas, such as the inferior frontal gyrus and superior temporal gyrus. No interactions between group, sentence complexity, and task were found in the neuroimaging data. Conclusions The results suggest that listeners with hearing loss process speech differently from their normal-hearing peers, possibly due to the increased demands of processing degraded auditory input. Increased cognitive demands by means of a secondary visual shape processing task influence neural sentence processing, but no evidence was found that it does so in a different way for listeners with hearing loss and normal-hearing listeners.

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