scholarly journals Breast Columnar Cell Mucinous Carcinoma

2020 ◽  
Author(s):  
Keyword(s):  
Mucinous Carcinoma ◽  
Columnar Cell

scholarly journals Mucinous breast carcinoma with tall columnar cells

2018 ◽  
Vol 100 (5) ◽  
pp. e132-e135 ◽  
Author(s):  
N Tsoukalas ◽  
M Kiakou ◽  
M Tolia ◽  
ID Kostakis ◽  
M Galanopoulos ◽  
...  
Keyword(s):  
Ductal Carcinoma ◽  
Mucinous Carcinoma ◽  
Signet Ring Cell ◽  
Columnar Cell ◽  
World Health ◽  
Clinical Staging ◽  
Breast Cancers ◽  
Carcinoma Of The Breast ◽  
Surgical Specimen ◽  
Columnar Cells

Mucinous carcinoma of the breast represents 1%–4% of all breast cancers. The World Health Organization classification divides this type of tumour into three different subtypes: mucinous carcinoma, mucinous carcinoma with tall columnar cells (mucinous cystadenocarcinoma and columnar cell mucinous carcinoma) and signet ring cell carcinoma. A 74-year-old woman presented a tumour with inflammatory features in the upper outer quadrant of her left breast, 7 cm in diameter. The core biopsy showed infiltrating ductal carcinoma of no specific type. The tumour-node-metastasis clinical staging was T4cN3M0 (Stage IIIC). She received neoadjuvant chemotherapy, underwent left mastectomy with radical axillary resection and subsequently received radiotherapy and chemotherapy. The histological examination of the surgical specimen revealed two solid tumors in the tail of Spence, which corresponded to adenocarcinoma with high columnar cells. The patient died 16 months after the diagnosis, suffering from pulmonary metastases and anterior chest wall infiltration. A review of the literature revealed only 21 reports of mucinous carcinoma of the breast with tall columnar cells, including our case. This is only the third time that the specific histological type of columnar cell mucinous carcinoma has been reported in the literature.

Ultrastructural Localization Study of Carcinoembryonic Antigen (CEA) in Gastric Cancer: Immunoelectron Microscopic Observation

1990 ◽  
Vol 48 (3) ◽  
pp. 252-253
Author(s):  
Dong Yuming ◽  
Yang Guanglin ◽  
Wu Jifeng ◽  
Chen Xiaolin
Keyword(s):  
Gastric Cancer ◽  
Intestinal Metaplasia ◽  
Cancer Cells ◽  
Microscopic Observation ◽  
Biological Significance ◽  
Ultrastructural Localization ◽  
Mucinous Carcinoma ◽  
Surface Glycoprotein ◽  
Tubular Adenocarcinoma ◽  
Pap Method

On the basis of light microscopic observation, the ultrastructural localization of CEA in gastric cancer was studied by immunoelectron microscopic technique. The distribution of CEA in gastric cancer and its biological significance and the mechanism of abnormal distribution of CEA were further discussed.Among 104 surgically resected specimens of gastric cancer with PAP method at light microscopic level, the incidence of CEA(+) was 85.58%. All of mucinous carcinoma exhibited CEA(+). In tubular adenocarcinoma the incidence of CEA(+) showed a tendency to rising with the increase of degree of differentiation. In normal epithelia and intestinal metaplasia CEA was faintly present and was found only in the luminal surface. The CEA staining patterns in cancer cells were of three types--- cytoplasmic, membranous and weak reactive type. The ultrastructural localization of CEA in 14 cases of gastric cancer was studied by immunoelectron microscopic technique.There was a little or no CEA in the microvilli of normal epithelia. In intestinal metaplasia CEA was found on the microvilli of absorptive cells and among the mucus particles of goblet cells. In gastric cancer CEA was also distributed on the lateral and basal surface or even over the entire surface of cancer cells and lost their polarity completely. Many studies had proved that the alterations in surface glycoprotein were characteristic changes of tumor cells. The antigenic determinant of CEA was glycoprotein, so the alterations of tumor-associated surface glycoprotein opened up a new way for the diagnosis of tumors.

Histopathological and genetic characterization of colorectal mucinous carcinoma

2001 ◽  
Vol 120 (5) ◽  
pp. A166-A166
Author(s):  
S FUJII ◽  
T KUSAKA ◽  
T KAIHARA ◽  
Y UEDA ◽  
T CHIBA ◽  
...  
Keyword(s):  
Genetic Characterization ◽  
Mucinous Carcinoma

scholarly journals Immunohistochemical Biomarkers as a Surrogate of Molecular Analysis in Ovarian Carcinomas: A Review of the Literature

Diagnostics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 199 ◽  
Author(s):  
Giacomo Santandrea ◽  
Simonetta Piana ◽  
Riccardo Valli ◽  
Magda Zanelli ◽  
Elisa Gasparini ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Molecular Analysis ◽  
Immunohistochemical Analysis ◽  
Cost Effective ◽  
Mucinous Carcinoma ◽  
Serous Carcinoma ◽  
Malignant Neoplasms ◽  
Low Grade ◽  
Ovarian Carcinomas ◽  
Novel Target

The term “ovarian carcinoma” encompasses at least five different malignant neoplasms: high-grade serous carcinoma, low-grade serous carcinoma, endometrioid carcinoma, mucinous carcinoma, and clear cell carcinoma. These five histotypes demonstrated distinctive histological, molecular, and clinical features. The rise of novel target therapies and of a tailored oncological approach has demanded an integrated multidisciplinary approach in the setting of ovarian carcinoma. The need to implement a molecular-based classification in the worldwide diagnostic and therapeutic setting of ovarian cancer demanded a search for easy-to-use and cost-effective molecular-surrogate biomarkers, relying particularly on immunohistochemical analysis. The present review focuses on the role of immunohistochemistry as a surrogate of molecular analysis in the everyday diagnostic approach to ovarian carcinomas.

Genomic Profile of Columnar Cell Variant of Papillary Thyroid Carcinoma

2021 ◽  
Author(s):  
Tyler Janovitz ◽  
Drew F.K. Williamson ◽  
Kristine S. Wong ◽  
Fei Dong ◽  
Justine A. Barletta
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Columnar Cell ◽  
Genomic Profile ◽  
Papillary Thyroid ◽  
Cell Variant ◽  
Columnar Cell Variant

Evaluation of preoperative prognostic factors in patients with resectable invasive intraductal papillary mucinous carcinoma

Surgery ◽  
2020 ◽  
Vol 168 (6) ◽  
pp. 994-1002 ◽  
Author(s):  
Wataru Izumo ◽  
Ryota Higuchi ◽  
Toru Furukawa ◽  
Takehisa Yazawa ◽  
Shuichiro Uemura ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Mucinous Carcinoma

scholarly journals EP1.15-27 One Case of Mucinous Carcinoma of Thymus Caused Bone Marrow Metastasis

2019 ◽  
Vol 14 (10) ◽  
pp. S1062-S1063
Author(s):  
T. Omori ◽  
H. Takahashi ◽  
T. Tachibana ◽  
O. Uchida ◽  
H. Hirano ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mucinous Carcinoma ◽  
Bone Marrow Metastasis
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