scholarly journals Mucinous carcinoma of the colon: correlation of loss of mismatch repair enzymes with clinicopathologic features and survival

2004 ◽  
Vol 17 (6) ◽  
pp. 696-700 ◽  
Author(s):  
Sanjay Kakar ◽  
Saime Aksoy ◽  
Lawrence J Burgart ◽  
Thomas C Smyrk
Keyword(s):  
Mismatch Repair ◽  
Mucinous Carcinoma ◽  
Clinicopathologic Features ◽  
Carcinoma Of The Colon ◽  
Repair Enzymes

scholarly journals The Conversion Gradient at HIS4 of Saccharomyces cerevisiae. I. Heteroduplex Rejection and Restoration of Mendelian Segregation

Genetics ◽  
1999 ◽  
Vol 153 (2) ◽  
pp. 555-572 ◽  
Author(s):  
Kenneth J Hillers ◽  
Franklin W Stahl
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Mismatch Repair ◽  
Dna Double Strand Breaks ◽  
Mendelian Segregation ◽  
Strand Breaks ◽  
Conversion Model ◽  
Repair Enzymes ◽  
Heteroduplex Rejection ◽  
Aberrant Segregation ◽  
Hybrid Dna

Abstract In Saccharomyces cerevisiae, some gene loci manifest gradients in the frequency of aberrant segregation in meiosis, with the high end of each gradient corresponding to a hotspot for DNA double-strand breaks (DSBs). The slope of a gradient is reduced when mismatch repair functions fail to act upon heteroduplex DNA—aberrant segregation frequencies at the low end of the gradient are higher in the absence of mismatch repair. Two models for the role of mismatch repair functions in the generation of meiotic “conversion gradients” have been proposed. The heteroduplex rejection model suggests that recognition of mismatches by mismatch repair enzymes limits hybrid DNA flanking the site of a DSB. The restoration-conversion model proposes that mismatch repair does not affect the length of hybrid DNA, but instead increasingly favors restoration of Mendelian segregation over full conversion with increasing distance from the DSB site. In our experiment designed to distinguish between these two models, data for one subset of well repairable mismatches in the HIS4 gene failed to show restoration-type repair but did indicate reduction in the length of hybrid DNA, supporting the heteroduplex rejection model. However, another subset of data manifested restoration-type repair, indicating a relationship between Holliday junction resolution and mismatch repair. We also present evidence for the infrequent formation of symmetric hybrid DNA during meiotic DSB repair.

scholarly journals Clinicopathologic Features of Signet-ring Cell Carcinoma of the Colon and Rectum

2006 ◽  
Vol 39 (1) ◽  
pp. 16-22 ◽  
Author(s):  
Tomoki Makino ◽  
Hideyuki Mishima ◽  
Masakazu Ikenaga ◽  
Toshimasa Tsujinaka ◽  
Masashi Takeda ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Clinicopathologic Features ◽  
Carcinoma Of The Colon ◽  
Signet Ring ◽  
Colon And Rectum ◽  
Ring Cell

CLINICAL AND PATHOLOGICAL FEATURES OF MUCINOUS CARCINOMA OF THE COLON AND RECTUM

1987 ◽  
Vol 48 (5) ◽  
pp. 609-614
Author(s):  
Masahiro OKUNO ◽  
Teruyuki IKEHARA ◽  
Masayoshi NAGAYAMA ◽  
Yasuyuki KATO ◽  
Saburo YUI ◽  
...  
Keyword(s):  
Mucinous Carcinoma ◽  
Pathological Features ◽  
Carcinoma Of The Colon ◽  
Colon And Rectum ◽  
Clinical And Pathological Features

Comprehensive Clinicopathologic and Updated Immunohistochemical Characterization of Primary Ovarian Mucinous Carcinoma

2018 ◽  
Vol 26 (4) ◽  
pp. 306-317 ◽  
Author(s):  
Dina Bassiouny ◽  
Nadia Ismiil ◽  
Valerie Dubé ◽  
Guangming Han ◽  
Matthew Cesari ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Advanced Disease ◽  
Mucinous Carcinoma ◽  
Therapeutic Options ◽  
Clinicopathologic Features ◽  
Napsin A ◽  
Mucinous Ovarian Carcinoma ◽  
Mmr Proteins ◽  
Her2 Positivity

The distinction of primary mucinous ovarian carcinoma (PMOC) from other primaries or secondaries is essential for selecting therapeutic options and prognostication. We aimed to characterize the immunohistochemical profile of 36 PMOCs using an extended immunohistochemical panel, with clinicopathologic features and outcome. PAX8 was negative in 30 (83.3%), and SATB2 was negative in 32/35. HNF1B, AMACR, and napsin-A were detected in 33 (91.7%), 35 (97.2%), and 0 (0%), respectively. MMR proteins and ARID1A were retained in 100%; PTEN was lost in 4 (11.1%). P53 was aberrant in 10 (27.8%); none overexpressed p16. HER2 was positive in 6/35 (17.1%). Most PMOCs had a favorable outcome. However, recurrence is usually fatal. The typical tumor profile was CK7+, CK20+/−, CDX2+/−, PAX8−, ER−, PgR−, and SATB2−. HER2 positivity suggests a possible target for therapy in advanced disease.

Detection of DNA point mutations with DNA mismatch repair enzymes

1994 ◽  
Vol 15 (8) ◽  
pp. 1657-1662 ◽  
Author(s):  
Ih-Chang Hsu ◽  
QiuPing Yang ◽  
Myong W. Kahng ◽  
Jing-Fan Xu
Keyword(s):  
Mismatch Repair ◽  
Dna Mismatch Repair ◽  
Point Mutations ◽  
Dna Mismatch ◽  
Repair Enzymes

scholarly journals Theswi4+gene ofSchizosaccharomyces pombeencodes a homologue of mismatch repair enzymes

1992 ◽  
Vol 20 (9) ◽  
pp. 2271-2278 ◽  
Author(s):  
Oliver Fleck ◽  
Holger Michael ◽  
Lutz Heim
Keyword(s):  
Mismatch Repair ◽  
Repair Enzymes

scholarly journals CLINICOPATHOLOGICAL STUDY OF POORLY DIFFERENTIATED ADENOCARCINOMA AND MUCINOUS CARCINOMA OF THE COLON

1993 ◽  
Vol 43 (2) ◽  
pp. 147-152
Author(s):  
TOMIO SAWADA ◽  
SUSUMU OHWADA ◽  
IZUMI TAKEYOSHI ◽  
SEIJI NAKAMURA ◽  
YUKIO MIYAMOTO ◽  
...  
Keyword(s):  
Mucinous Carcinoma ◽  
Poorly Differentiated Adenocarcinoma ◽  
Carcinoma Of The Colon ◽  
Clinicopathological Study ◽  
Poorly Differentiated
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