scholarly journals Wheal Size

2020 ◽  
Author(s):  
Keyword(s):  
Wheal Size

scholarly journals Adjusting wheal size measures to correct atopy misclassification

2011 ◽  
pp. 597 ◽  
Author(s):  
Hongmei Zhang ◽  
Karmaus ◽  
Jian-Jun Gan ◽  
Bao ◽  
Zhao ◽  
...  
Keyword(s):  
Wheal Size

Automated measurement of skin prick tests: an advance towards exact calculation of wheal size

2006 ◽  
Vol 15 (2) ◽  
pp. 119-124 ◽  
Author(s):  
Stefan Wohrl ◽  
Kornelia Vigl ◽  
Michael Binder ◽  
Georg Stingl ◽  
Michael Prinz
Keyword(s):  
Exact Calculation ◽  
Automated Measurement ◽  
Skin Prick Tests ◽  
Wheal Size

Temelastine, a New H1-Receptor Antagonist

1986 ◽  
Vol 14 (4) ◽  
pp. 200-204 ◽  
Author(s):  
Fred Alexander ◽  
Robert M Stote ◽  
Nancy Allison ◽  
Robert G Familiar ◽  
Dianne Tatoian ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Plasma Concentrations ◽  
Controlled Study ◽  
Blood Levels ◽  
Double Blind Study ◽  
Double Blind ◽  
The Central Nervous System ◽  
H1 Receptor Antagonist ◽  
Oral Doses ◽  
Wheal Size

Temelastine is a selective, competitive histamine H1-receptor antagonist which does not penetrate the central nervous system. The effect of varying doses of temelastine was compared in a randomized, double-blind, controlled study by measuring the inhibition of cutaneous histamine wheals. In twelve subjects single oral doses of 50, 100 and 200 mg of temelastine produced dose-dependent reductions in wheal areas. The inhibition of wheal size was maximal by 2 hr after dosing and was present at 8 hr. At 2 hr the 50, 100, and 200 mg doses reduced the wheal size by 53, 64, and 78%, respectively. Chlorpheniramine, 4 mg, reduced wheal size by 32% at the same period. The ability of temelastine to antagonize the histamine-induced skin reaction over 20 hr was evaluated in a second randomized, double-blind study. Eight subjects participated. Temelastine, 100 mg, produced reductions of 64, 49, 56 and 51% in histamine wheal area at 8, 12, 16 and 20 hr, respectively. Plasma concentrations at these times were 4.04, 2.77, 1.88, and 1.44 μmol/l, respectively. These data suggest that blood levels as low as 1.44 μmol/l may be sufficient to produce an antihistaminic effect, and that daily or twice daily dosing with 100 mg may be adequate to control allergic symptoms.

scholarly journals Clinical relevance is associated with allergen‐specific wheal size in skin prick testing

2014 ◽  
Vol 44 (3) ◽  
pp. 407-416 ◽  
Author(s):  
T. Haahtela ◽  
G. J. Burbach ◽  
C. Bachert ◽  
C. Bindslev‐Jensen ◽  
S. Bonini ◽  
...  
Keyword(s):  
Clinical Relevance ◽  
Skin Prick Testing ◽  
Wheal Size

Mean Wheal Size from Peanut Prick Skin Test and IgE Levels in Peanut Allergic Patients Receiving Oral Peanut Immunotherapy

2008 ◽  
Vol 121 (2) ◽  
pp. S136-S136
Author(s):  
M ADAIR ◽  
S LAUBACH ◽  
P STEELE ◽  
J KAMILARIS ◽  
L PONS ◽  
...  
Keyword(s):  
Skin Test ◽  
Prick Skin Test ◽  
Wheal Size

scholarly journals Histamine 50-Skin-Prick Test: A Tool to Diagnose Histamine Intolerance

ISRN Allergy ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Lukas Kofler ◽  
Hanno Ulmer ◽  
Heinz Kofler
Keyword(s):  
Amine Oxidase ◽  
Gastrointestinal Symptoms ◽  
Control Group ◽  
Amine Oxidases ◽  
Prick Test ◽  
Histamine Intolerance ◽  
Validated Questionnaire ◽  
Wide Range ◽  
Key Enzyme ◽  
Wheal Size

Background. Histamine intolerance results from an imbalance between histamine intake and degradation. In healthy persons, dietary histamine can be sufficiently metabolized by amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine toxicity. Diamine oxidase (DAO) is the key enzyme in degradation. Histamine elicits a wide range of effects. Histamine intolerance displays symptoms, such as rhinitis, headache, gastrointestinal symptoms, palpitations, urticaria and pruritus. Objective. Diagnosis of histamine intolerance until now is based on case history; neither a validated questionnaire nor a routine test is available. It was the aim of this trial to evaluate the usefullness of a prick-test for the diagnosis of histamine intolerance. Methods. Prick-testing with 1% histamine solution and wheal size-measurement to assess the relation between the wheal in prick-test, read after 20 to 50 minutes, as sign of slowed histamine degradation as well as history and symptoms of histamine intolerance. Results. Besides a pretest with 17 patients with HIT we investigated 156 persons (81 with HIT, 75 controls): 64 out of 81 with histamine intolerance(HIT), but only 14 out of 75 persons from the control-group presented with a histamine wheal ≥3 mm after 50 minutes (). Conclusion and Clinical Relevance. Histamine-50 skin-prickt-test offers a simple tool with relevance.

Comparison of Multi-Test Device Skin Testing and Modified RAST Results

1998 ◽  
Vol 118 (6) ◽  
pp. 797-799 ◽  
Author(s):  
JONATHAN L. LEVINE ◽  
RICHARD L. MABRY ◽  
CYNTHIA S. MABRY
Keyword(s):  
Skin Testing ◽  
Test System ◽  
Test Results ◽  
Allergy Test ◽  
Preliminary Study ◽  
Inhalant Allergy ◽  
The Relationship ◽  
Wheal Size ◽  
Head Neck

The initial purpose of this study was to determine the potential correlation between allergy test results obtained with the Multi-Test skin testing method and the radioallergosorbent test (RAST) blood test (used as a “standard”). Twenty patients with a history and physical examination findings suggestive of inhalant allergy underwent both a Multi-Test system screen (14 antigens plus histamine and glycerine controls) and RAST testing. The relationship between wheal size and Multi-Test system grade for each antigen and the corresponding RAST class was studied. The correlation between positive Multi-Test system and RAST results was poor, with an average agreement by antigen of 56.26% and overall agreement of 67.86%. However, the overall agreement between negative Multi-Test system results (≠1+) and negative RAST results (≠class I) was 95.15%, with an average agreement by antigen of 83.99%. On the basis of results of this preliminary study, it appears that a negative Multi-Test system result indicates that significant inhalant allergy is unlikely, whereas a positive Multi-Test system result necessitates follow-up with more definitive testing by additional skin testing or RAST. (Otolaryngol Head Neck Surg 1998;118:797–9.)

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