scholarly journals Clinical relevance is associated with allergen‐specific wheal size in skin prick testing

2014 ◽  
Vol 44 (3) ◽  
pp. 407-416 ◽  
Author(s):  
T. Haahtela ◽  
G. J. Burbach ◽  
C. Bachert ◽  
C. Bindslev‐Jensen ◽  
S. Bonini ◽  
...  
Keyword(s):  
Clinical Relevance ◽  
Skin Prick Testing ◽  
Wheal Size

Comparison of Intradermal Dilutional Testing, Skin Prick Testing, and Modified Quantitative Testing for Common Allergens

2007 ◽  
Vol 137 (2) ◽  
pp. 246-249 ◽  
Author(s):  
Jacques Peltier ◽  
Matthew W. Ryan
Keyword(s):  
Clinical Study ◽  
Study Design ◽  
Skin Prick Testing ◽  
Immediate Hypersensitivity ◽  
Safe Alternative ◽  
Comparative Clinical Study ◽  
Wheal Size

OBJECTIVES: To compare and correlate wheal size using the Multi-Test II applicator with the endpoint obtained by intradermal dilutional testing (IDT) for 5 common allergens. To examine the safety of modified quantitative testing (MQT) for determining immunotherapy starting doses. STUDY DESIGN: Prospective comparative clinical study. SUBJECTS AND METHODS: A total of 134 subjects were simultaneously skin tested for immediate hypersensitivity using the Multi-Test II device and IDT. RESULTS: There was a 77% concordance between results from IDT and results from MQT. When there was a difference, MQT predicted a safer endpoint for starting immunotherapy in all but 2 cases. CONCLUSION: Wheal size by SPT is predictive of endpoint by IDT. MQT is nearly as effective as formal IDT in determining endpoint. SIGNIFICANCE: Modified quantitative testing appears to be a safe alternative to IDT for determining starting doses for immunotherapy.

Use of Intradermal Dilutional Testing and Skin Prick Testing: Clinical Relevance and Cost Efficiency

2006 ◽  
Vol 116 (9) ◽  
pp. 1530-1538 ◽  
Author(s):  
Merritt Seshul ◽  
Harold Pillsbury ◽  
Thomas Eby
Keyword(s):  
Cost Efficiency ◽  
Clinical Relevance ◽  
Skin Prick Testing

scholarly journals Low Potency of Indian Dust Mite Allergen Skin Prick Test Extracts Compared to FDA-Approved Extracts: A Double-Blinded Randomized Control Trial

2018 ◽  
Vol 9 ◽  
pp. 215265671879674 ◽  
Author(s):  
Devasahayam J. Christopher ◽  
Narmada Ashok ◽  
Aruna Ravivarma ◽  
Deepa Shankar ◽  
Erik Peterson ◽  
...  
Keyword(s):  
Immunoglobulin E ◽  
Skin Prick Testing ◽  
Statistical Significance ◽  
Skin Testing ◽  
Allergic Diseases ◽  
Allergen Extract ◽  
Prick Test ◽  
Full Strength ◽  
Dust Mite ◽  
Wheal Size

Background Skin prick testing is the most important diagnostic tool to detect immunoglobulin E-mediated allergic diseases. With increase in the number of allergy tests performed in India, it is imperative to know the potency of indigenous extracts in comparison with U.S. Food and Drug Administration (USFDA)-approved extracts. Methods A randomized comparison trial of Indian manufactured and USFDA-approved extracts of Dermatophagoides pteronyssinus (DP) and Dermatophagoides farinae (DF) was done at Christian Medical College & Hospital, Vellore, India from April 2014 to June 2015, to compare the skin test reactivity of indigenous allergen extracts of dust mites against validated allergen. Study enrollment included 197 patients with allergic disorders that showed sensitivity to dust mite during routine allergy skin testing. Study participants were tested with varying dilutions of DP and DF indigenous extracts along with USFDA-approved allergens in a blinded fashion. Results were recorded, and statistical significance was calculated using the Friedman rank sum test. Results Using the Friedman rank sum test with a Tukey adjustment for multiple comparisons, we found that the extracts in each dilution were significantly different ( P < .0001). The full strength indigenous extracts, B-DF (DF allergen standard extract from Bioproducts and Diagnostics, India) and C-DF (DF allergen extract from Creative Diagnostics, India) extracts, had mean wheal sizes of 7.69 (standard deviation [SD] 9.91) and 31.01(SD 51.04), respectively. The full strength S-DF (DF allergen extract from Jubilant Hollister Stier, Spokane, WA, USA) had a mean wheal size of 109.97 (SD 162.73), which was significantly higher ( P < .0001) than both the indigenous extracts. For each of the dilutions, the S-DF mean wheal size was significantly greater than that of the corresponding B-DF and C-DF wheal sizes. The full strength indigenous C-DP (DP allergen extract from Creative Diagnostics, India) had mean wheal size of 39.37 (SD 51.74). The full strength standard S-DP (DP allergen extract from Jubilant Hollister Stier, Spokane, WA, USA) extract had a mean wheal size of 167.66 (SD 270.80), which was significantly higher ( P < .0001) than the indigenous C-DP extract. Similar differences were seen across all dilutions. Conclusion The indigenous extracts have significantly lower potency compared to USFDA-approved extracts; hence, there is an urgent need for policy makers to institute stringent criteria for standardization of antigens in India.

Selected Abstracts of Recent Research in Stuttering

1999 ◽  
Vol 9 (1) ◽  
pp. 5-6
Author(s):  
Carrie Bain ◽  
Nan Bernstein Ratner
Keyword(s):  
Large Volume ◽  
Clinical Relevance

Due to the large volume of fluency-related publications since the last column, we have chosen to highlight those articles of highest potential clinical relevance.

259: Evaluation and Clinical Relevance of Prognostic Molecular Risk Factors in Prostate Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 86-86
Author(s):  
Roland Bonfig ◽  
Hubertus Riedmiller ◽  
Burkhardt Kneitz ◽  
Philipp Stroebel
Keyword(s):  
Prostate Cancer ◽  
Risk Factors ◽  
Clinical Relevance

52: Clinical Relevance of Local Recurrence in Neobladders

2004 ◽  
Vol 171 (4S) ◽  
pp. 14-14
Author(s):  
Dieter R. Echtle ◽  
Elizabeth M. Mueller ◽  
Detlef H. Frohneberg
Keyword(s):  
Local Recurrence ◽  
Clinical Relevance
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