scholarly journals Albumin Clearance

2020 ◽  
Author(s):  
Keyword(s):  
Albumin Clearance

Intrapleural liquid flow down a gravity-dependent hydraulic pressure gradient

1988 ◽  
Vol 64 (2) ◽  
pp. 577-584 ◽  
Author(s):  
G. Miserocchi ◽  
D. Negrini ◽  
M. Pistolesi ◽  
C. R. Bellina ◽  
M. C. Gilardi ◽  
...  
Keyword(s):  
Pressure Gradient ◽  
Time Course ◽  
Sudden Change ◽  
Vertical Movement ◽  
Rate Of Change ◽  
Large Field ◽  
Liquid Volume ◽  
Hydraulic Pressure ◽  
Albumin Clearance ◽  
Turning Maneuver

We studied the vertical movement of 2 mg technetium-labeled albumin injected intrapleurally in 0.5 ml saline (15% of pleural liquid volume) in eight spontaneously breathing anesthetized dogs subject to a sudden change in posture (prone to supine or vice versa). The albumin movements were evaluated through a large field gamma camera placed laterally to the animal and detecting total (AT) and regional activities from two superimposed equal areas (At and Ab, top and bottom, respectively). The At/Ab ratio decreased from 2.1 to 1.3 in four animals up to 20 min from the change in posture and from 0.9 to 0.5 in four more animals studied from 50 to 90 min from turning maneuver. The rate of change in At and Ab was similar in the two groups of animals and unaffected by the acquisition posture. AT decreased by 7.7 and 3.5% for the two groups, respectively, reflecting albumin clearance from the pleural space. The opposite time course of regional activities and the independence of their rate of change of the At/Ab ratio and of the animal posture suggest a top-to-bottom albumin transfer occurring through a bulk flow of liquid estimated at 0.006 ml.kg-1.h-1. The data are consistent with a measured vertical pleural liquid pressure gradient that does not reflect a hydrostatic condition.

Simultaneous measurement of fluid and protein permeability in isolated rabbit lungs during edema

1992 ◽  
Vol 73 (6) ◽  
pp. 2440-2447 ◽  
Author(s):  
P. A. Vincent ◽  
P. B. Kreienberg ◽  
F. L. Minnear ◽  
T. M. Saba ◽  
D. R. Bell
Keyword(s):  
Pulmonary Edema ◽  
Venous Pressure ◽  
Experimental Period ◽  
Hemodynamic Effects ◽  
Lung Weight ◽  
Isolated Lung ◽  
Pulmonary Arterial Catheter ◽  
Pressure Independent ◽  
Albumin Clearance ◽  
Protein Permeability

Fluid conductance and protein permeability have been studied in isolated perfused lung models of pulmonary edema. However, previous studies have not investigated changes of both fluid conductance and protein permeability in the same isolated lung preparation after injury. Arachidonic acid (AA) metabolites are involved in the inflammatory processes that lead to the development of pulmonary edema. The hemodynamic effects of AA have been well established; however, controversy exists concerning the ability of AA to alter the permeability of the pulmonary microvasculature to fluid and protein. The purpose of this study was to simultaneously determine whether transvascular fluid conductance and protein permeability are increased in isolated perfused rabbit lungs with pulmonary edema induced by AA. Indomethacin (80 microM) was added to the perfusate to inhibit the hemodynamic effects of AA and produce a pressure-independent model of pulmonary edema. Fluid conductance was assessed by determination of the capillary filtration coefficient (Kf), and protein permeability was evaluated by measurement of 125I-albumin clearance. The injection of AA (3 mg/200 ml of perfusate) into the pulmonary arterial catheter resulted in an increase in lung weight over the remaining 30-min experimental period. Kf (microliter.s-1 x cmH2O-1 x g dry lung-1) was increased (P < 0.05) in AA-treated lungs at 10 and 30 min post-AA injection when compared with control lungs and baseline values (determined 10 min before AA injection). Albumin clearance was also greater (P < 0.05) in lungs that received AA. 125I-albumin clearance was measured at different rates of fluid flux produced by elevation of venous pressure.(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals SP520PERITONEAL ALBUMIN CLEARANCE AND NOT PROTEIN PREDICTS CARDIOVASCULAR RISK IN PERITONEAL DIALYSIS PATIENTS

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii550-iii551
Author(s):  
Mooyong Park ◽  
Soo Jeong Choi ◽  
Seung Duk Hwang ◽  
Jin Kuk Kim ◽  
Hye Min Jo
Keyword(s):  
Peritoneal Dialysis ◽  
Cardiovascular Risk ◽  
Dialysis Patients ◽  
Albumin Clearance

Plasma ANP levels and protein extravasation during graded expansion with equilibrated whole blood

1996 ◽  
Vol 271 (3) ◽  
pp. R601-R609 ◽  
Author(s):  
V. L. Tucker
Keyword(s):  
Body Weight ◽  
Volume Expansion ◽  
Venous Pressure ◽  
The Body ◽  
Protein Distribution ◽  
Central Venous ◽  
Pentobarbital Sodium ◽  
Protein Extravasation ◽  
Albumin Clearance ◽  
The Relationship

The relationship between plasma immunoreactive atrial natriuretic peptide (irANP) and radiolabeled albumin clearance (CBSA) in multiple tissues after graded volume stimuli was examined. To obtain a pure volume stimulus, pentobarbital sodium-anesthetized rats (5 or 6 per group) were equilibrated with a reservoir of blood by a femoral arteriovenous shunt, and volume expansion (VE) was produced by adjusting reservoir outflow. Peak increases in central venous pressure (CVP) during VE equal to 2 and 4% of the body weight over 5 min were 3.6 +/- 0.2 and 7.0 +/- 0.3 mmHg, and plasma irANP levels measured at 40 min post-VE were elevated 1.9- and 4.1-fold above baseline, respectively. Graded increases in CBSA measured between 5 and 35 min post-VE occurred in selective tissues, including intestine, visceral fat, lung, and muscle (P < or = 0.05). In separate animals, the level of VE was maintained after 2% VE by slower administration of an additional 2% VE for the remaining 30 min. This resulted in a more sustained CVP elevation and larger increases in irANP levels and CBSA compared with either 2 or 4% VE. Furthermore, equations derived from previous work in this laboratory involving intravenous administration of ANP predicted the magnitude of CBSA elevation during maintained VE. These findings support a role for ANP in regulating transcapillary protein distribution during acute intravascular expansion.

Protein, not adenosine or adenine nucleotides, mediates platelet decrease in endothelial permeability

1997 ◽  
Vol 273 (5) ◽  
pp. H2304-H2311 ◽  
Author(s):  
Sandeep Patil ◽  
John E. Kaplan ◽  
Fred L. Minnear
Keyword(s):  
High Performance ◽  
Adenine Nucleotides ◽  
Endothelial Permeability ◽  
Platelet Response ◽  
Cell Monolayers ◽  
Adenosine Receptor Antagonist ◽  
Albumin Clearance ◽  
Protein Permeability

Platelets and platelet-conditioned medium (PCM) decrease endothelial protein permeability in vitro. Adenosine and a >100-kDa protein have previously been implicated as the soluble factors released from platelets that decrease endothelial permeability. The objective of this study was to further investigate the role of adenosine in this platelet response. Measurements of adenosine and its precursor adenine nucleotides by high-performance liquid chromatography were correlated with the assessment of permeability by125I-labeled albumin clearance and electrical resistance across endothelial cell monolayers derived from the bovine pulmonary artery. PCM contained micromolar concentrations of AMP, ADP, and ATP, but adenosine was below detectable levels (≤0.1 μM). Adenosine deaminase, an enzyme that converts adenosine to inactive inosine, or an adenosine-receptor antagonist did not block the platelet- or PCM-mediated decrease in endothelial permeability. A <3-kDa fraction of PCM that contained micromolar concentrations of AMP and ADP did not affect endothelial permeability, whereas a >3-kDa fraction that contained much reduced levels of AMP and ADP significantly decreased permeability. This activity of PCM was sensitive to insoluble trypsin. This study rules out adenosine and adenine nucleotides as primary factors in the platelet-induced decrease in endothelial permeability and suggests that the active factor is a protein.

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