scholarly journals CCL2 Gene

2020 ◽  
Author(s):  
Keyword(s):  
Ccl2 Gene

Association of CCL2 Gene Variants with Osteoarthritis

2019 ◽  
Vol 50 (3) ◽  
pp. 86-90 ◽  
Author(s):  
Zhonghua Xu ◽  
Jin Li ◽  
Haoyu Yang ◽  
Lifeng Jiang ◽  
Xindie Zhou ◽  
...  
Keyword(s):  
Gene Variants ◽  
Ccl2 Gene

scholarly journals Novel Regulation of CCL2 Gene Expression by Murine LITAF and STAT6B

PLoS ONE ◽  
2011 ◽  
Vol 6 (9) ◽  
pp. e25083 ◽  
Author(s):  
Xiaoren Tang ◽  
Yu Yang ◽  
Salomon Amar
Keyword(s):  
Gene Expression ◽  
Ccl2 Gene

scholarly journals Upregulation of IL-6, IL-8 and CCL2 gene expression after acute inflammation: Correlation to clinical pain

Pain ◽  
2009 ◽  
Vol 142 (3) ◽  
pp. 275-283 ◽  
Author(s):  
Xiao-Min Wang ◽  
May Hamza ◽  
Tian-Xia Wu ◽  
Raymond A. Dionne
Keyword(s):  
Gene Expression ◽  
Acute Inflammation ◽  
Clinical Pain ◽  
Ccl2 Gene

No association between CCL2 gene polymorphisms and risk of inflammatory demyelinating diseases in a Korean population

2014 ◽  
Vol 84 (2) ◽  
pp. 223-228 ◽  
Author(s):  
S. Namgoong ◽  
J. S. Bae ◽  
H. S. Cheong ◽  
J.-H. Kim ◽  
J. Y. Kim ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Demyelinating Diseases ◽  
Korean Population ◽  
Ccl2 Gene

scholarly journals Study of ultrasound-guided ropivacaine combined with butorphanol continuous paravertebral block to prevent pain syndrome by evaluating ccl2 gene expression after radical mastectomy

2022 ◽  
Vol 67 (4) ◽  
pp. 264-273
Author(s):  
Xiaochen Ji ◽  
Wenbin Cui ◽  
Shiqiang Shan ◽  
Xiaomeng Liu ◽  
Lixian Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Radical Mastectomy ◽  
Pain Syndrome ◽  
Lymph Node Biopsy ◽  
Paravertebral Block ◽  
Control Group ◽  
Observation Group ◽  
Ultrasound Guided ◽  
Ccl2 Gene

This study aimed to investigate the clinical effect of ultrasound-guided ropivacaine combined with butorphanol continuous paravertebral block in preventing postoperative pain syndrome of breast cancer. For this purpose, 100 women treated for breast cancer from April 2018 to July 2019 were enrolled as research objects. Surgical procedures included local sentinel lymph node biopsy, mastectomy, sentinel lymph node biopsy for mastectomy, modified radical mastectomy, and implantation. The selected patients were randomly divided into two groups: control group (routine operation anesthesia; n = 50) and observation group (ultrasound-guided thoracic paravertebral block before induction of ropivacaine+butorphanol anesthesia; n = 50). The Real-time PCR technique was performed to evaluate CCL2 gene expression. VAS scores were recorded during the postoperative period. Compared with the control group, the observation group had lower VAS scores at six h, 24h, and 48h (P<0.05). The pain effect of the observation group was less than that of the control group. The observation group had better analgesic effects after anesthesia. The observation group had a lower incidence of pain syndrome at the 6th, 8th, and 12th months (P<0.05), and the incidence of pain syndrome in the two groups decreased with the extension of time. The observation group had lower levels of related factors (P<0.05), and the observation group had lower traumatic stress responses. The protein expression of IL-6, IL-17, and CRP in the observation group was lower than that in the control group (P<0.05). The results of CCL2 gene expression also showed that gene expression in the control group increased significantly (P=0.0047). Since the expression of this gene is one of the factors that stimulate pain signals in the body, the method used in the present study was able to reduce the amount of pain significantly. Therefore, the combination of ropivacaine combined with butorphanol ultrasound-assisted paravertebral block can reduce the intensity of postoperative pain in patients with breast cancer surgery, decrease the incidence of pain syndrome, and increase pain tolerance.

Combinations of Polymorphic Markers of Chemokine Genes, Their Receptors and Acute Phase Protein Genes As Potential Predictors of Coronary Heart Diseases

Acta Naturae ◽  
2016 ◽  
Vol 8 (1) ◽  
pp. 111-116 ◽  
Author(s):  
T. R. Nasibullin ◽  
L. F. Yagafarova ◽  
I. R. Yagafarov ◽  
Ya. R. Timasheva ◽  
V. V. Erdman ◽  
...  
Keyword(s):  
Acute Phase Protein ◽  
Heart Diseases ◽  
Polymorphic Markers ◽  
Coronary Heart Diseases ◽  
The Monte Carlo Method ◽  
Ccr2 Gene ◽  
Increased Risk ◽  
Phase Protein ◽  
Ccl2 Gene ◽  
Main Factor

Atherosclerosis, the main factor in the development of coronary heart diseases (CHD), is an inflammatory response to endothelial layer damage in the arterial bed. We have analyzed the association between CHD and the polymorphic markers of genes that control the synthesis of proteins involved in the processes of adhesion and chemotaxis of immunocompetent cells: rs1024611 (-2518AG, CCL2 gene), rs1799864 (V64I, CCR2 gene), rs3732378 (T280M, CX3CR1 gene), rs1136743 (A70V, SAA1 gene), and rs1205 (2042CT, CRP gene) in 217 patients with CHD and 250 controls. Using the Monte Carlo method and Markov chains (APSampler), we revealed a combination of alleles/genotypes associated with both a reduced and increased risk of CHD. The most significant alleles/genotypes areSAA1*T/T+CRP*C+CX3CR1*G/A (Pperm = 0.0056, OR = 0.07 95%CI 0.009-0.55),SAA1*T+CRP*T+CCR2*G/A+CX3CR1*G (Pperm = 0.0063, OR = 14.58 95%CI 1.88-113.04), SAA1*T+CCR2*A+CCL2* G/G (Pperm = 0.0351, OR = 10.77 95%CI 1.35-85.74).

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