No association between CCL2 gene polymorphisms and risk of inflammatory demyelinating diseases in a Korean population

2014 ◽  
Vol 84 (2) ◽  
pp. 223-228 ◽  
Author(s):  
S. Namgoong ◽  
J. S. Bae ◽  
H. S. Cheong ◽  
J.-H. Kim ◽  
J. Y. Kim ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Demyelinating Diseases ◽  
Korean Population ◽  
Ccl2 Gene

scholarly journals Association Between Toll-Like Receptors/CD14 Gene Polymorphisms and Inflammatory Bowel Disease in Korean Population

2012 ◽  
Vol 27 (1) ◽  
pp. 72 ◽  
Author(s):  
Eun Jung Kim ◽  
Woo Chul Chung ◽  
Kang-Moon Lee ◽  
Chang Nyol Paik ◽  
Sung Hoon Jung ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Gene Polymorphisms ◽  
Korean Population ◽  
Toll Like Receptors ◽  
Inflammatory Bowel ◽  
Cd14 Gene

scholarly journals No association of prion protein gene polymorphisms with Alzheimer's disease in Korean population

2006 ◽  
Vol 38 (6) ◽  
pp. 727-731 ◽  
Author(s):  
Kyungsook Ahn ◽  
Eunkyung Kim ◽  
Young-A Kwon ◽  
Doh Kwan Kim ◽  
Jong-Eun Lee ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Prion Protein ◽  
Gene Polymorphisms ◽  
Protein Gene ◽  
Korean Population ◽  
Prion Protein Gene

The relationships between endothelial nitric oxide synthase polymorphisms and the formation of intracranial aneurysms in the Korean population

2011 ◽  
Vol 30 (6) ◽  
pp. E23 ◽  
Author(s):  
Tae Gon Kim ◽  
Nam Keun Kim ◽  
Min Jung Baek ◽  
Ryoung Huh ◽  
Sang Sup Chung ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Patient Group ◽  
Endothelial Nitric Oxide Synthase ◽  
Gene Polymorphisms ◽  
Intracranial Aneurysms ◽  
Korean Population ◽  
Enos Gene ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Object Some genetic factors are known to be associated with the formation of cerebral aneurysms in the Caucasian population. One of these factors is endothelial nitric oxide synthase (eNOS) gene polymorphisms. Endothelial nitric oxide synthase genes encode eNOS, which synthesizes NO from l-arginine. There continues to be controversy about the relationships between eNOS gene polymorphisms and the formation of intracranial aneurysms. In this study, the authors evaluated these relationships in the Korean population. Methods Three eNOS polymorphisms (eNOS 27VNTR, T786C, and G894T) were genotyped in 96 patients with ruptured aneurysms, 53 patients with unruptured aneurysms, and in 121 volunteers via polymerase chain reaction–restriction fragment length polymorphism analysis. Results The mean ages of the patients and healthy volunteers were 52.9 ± 12.3 years and 55.2 ± 9.1 years, respectively. The patient group was composed of 56 men and 93 women, and the healthy volunteer group was composed of 46 men and 75 women. Only the incidence of smoking history was significantly higher in the patient group than in the control group (p = 0.001). The genotypic frequencies for the 3 eNOS gene polymorphisms were in agreement with those predicted by Hardy-Weinberg equilibrium. There were no significant associations between the eNOS recessive models and the formation of an aneurysm. The authors found no genotypic differences between similar races among patients with aneurysms. Conclusions The present study shows that eNOS 27VNTR, T786C, and G894T polymorphisms cannot be used as indicators of the formation of intracranial aneurysms in Korean patients. To confirm these findings an additional analyses might need to be performed using a larger sample size. There were no differences in the genotypic distributions and allelic frequencies between similar races among patients with aneurysms, which were the same in previously reported normal populations.

Association between OPG, RANK and RANKL gene polymorphisms and susceptibility to acute coronary syndrome in Korean population

2012 ◽  
Vol 91 (1) ◽  
pp. 87-89 ◽  
Author(s):  
WON-SEOK CHOE ◽  
HACK-LYOUNG KIM ◽  
JUNG-KYU HAN ◽  
YOUNG-EUN CHOI ◽  
BORAMI SEO ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Gene Polymorphisms ◽  
Korean Population ◽  
Coronary Syndrome
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