scholarly journals CD14 Gene

2020 ◽  
Author(s):  
Keyword(s):  
Cd14 Gene

Influence of promoter polymorphism in the CD14 gene on the course of Crohn's disease

2004 ◽  
Vol 42 (05) ◽  
Author(s):  
T Molnár ◽  
G Klausz ◽  
Z Gyulai ◽  
F Nagy ◽  
Y Mándy ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Promoter Polymorphism ◽  
Cd14 Gene

scholarly journals LPS-induced expression of CD14 in the TRIF pathway is epigenetically regulated by sulforaphane in porcine pulmonary alveolar macrophages

2016 ◽  
Vol 22 (8) ◽  
pp. 682-695 ◽  
Author(s):  
Qin Yang ◽  
Maren J Pröll ◽  
Dessie Salilew-Wondim ◽  
Rui Zhang ◽  
Dawit Tesfaye ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alveolar Macrophages ◽  
Methylation Status ◽  
Gene Body ◽  
Gene Body Methylation ◽  
Tnf Α ◽  
Pulmonary Alveolar Macrophages ◽  
Cluster Of Differentiation ◽  
Cd14 Gene

Pulmonary alveolar macrophages (AMs) are important in defense against bacterial lung inflammation. Cluster of differentiation 14 (CD14) is involved in recognizing bacterial lipopolysaccharide (LPS) through MyD88-dependent and TRIF pathways of innate immunity. Sulforaphane (SFN) shows anti-inflammatory activity and suppresses DNA methylation. To identify CD14 epigenetic changes by SFN in the LPS-induced TRIF pathway, an AMs model was investigated in vitro. CD14 gene expression was induced by 5 µg/ml LPS at the time point of 12 h and suppressed by 5 µM SFN. After 12 h of LPS stimulation, gene expression was significantly up-regulated, including TRIF, TRAF6, NF-κB, TRAF3, IRF7, TNF-α, IL-1β, IL-6, and IFN-β. LPS-induced TRAM, TRIF, RIPK1, TRAF3, TNF-α, IL-1β and IFN-β were suppressed by 5 µM SFN. Similarly, DNMT3a expression was increased by LPS but significantly down-regulated by 5 µM SFN. It showed positive correlation of CD14 gene body methylation with in LPS-stimulated AMs, and this methylation status was inhibited by SFN. This study suggests that SFN suppresses CD14 activation in bacterial inflammation through epigenetic regulation of CD14 gene body methylation associated with DNMT3a. The results provide insights into SFN-mediated epigenetic down-regulation of CD14 in LPS-induced TRIF pathway inflammation and may lead to new methods for controlling LPS-induced inflammation in pigs.

The Kinetic Expression of Lipopolysaccharide-Binding Protein and CD14 Gene in Obstructive Jaundice

2014 ◽  
Vol 28 (1) ◽  
pp. 18-23 ◽  
Author(s):  
Ching-Hua Tsai ◽  
Cheng-Hsi Yeh ◽  
Shyr-Ming Sheen-Chen ◽  
Chun-Ying Huang ◽  
Yueh-Wei Liu ◽  
...  
Keyword(s):  
Obstructive Jaundice ◽  
Binding Protein ◽  
Lipopolysaccharide Binding Protein ◽  
Kinetic Expression ◽  
Cd14 Gene ◽  
Lipopolysaccharide Binding

Suggestive evidence of association of C-159T functional polymorphism of the CD14 gene with atopic asthma in northern and northwestern Indian populations

2004 ◽  
Vol 56 (7) ◽  
pp. 544-547 ◽  
Author(s):  
Mamta Sharma ◽  
Jyotsna Batra ◽  
U. Mabalirajan ◽  
Sangeeta Goswami ◽  
Dipyaman Ganguly ◽  
...  
Keyword(s):  
Atopic Asthma ◽  
Functional Polymorphism ◽  
Indian Populations ◽  
Suggestive Evidence ◽  
Cd14 Gene

scholarly journals Association Between Toll-Like Receptors/CD14 Gene Polymorphisms and Inflammatory Bowel Disease in Korean Population

2012 ◽  
Vol 27 (1) ◽  
pp. 72 ◽  
Author(s):  
Eun Jung Kim ◽  
Woo Chul Chung ◽  
Kang-Moon Lee ◽  
Chang Nyol Paik ◽  
Sung Hoon Jung ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Gene Polymorphisms ◽  
Korean Population ◽  
Toll Like Receptors ◽  
Inflammatory Bowel ◽  
Cd14 Gene

scholarly journals Association between CD14 Gene Polymorphisms and Cancer Risk: A Meta-Analysis

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e100122 ◽  
Author(s):  
Jun Wang ◽  
Xufeng Guo ◽  
Shijie Yu ◽  
Jia Song ◽  
Jixiang Zhang ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Cd14 Gene

Porcine CD14 gene silencing partially inhibited the bacterial immune response mediated by TLR4 signaling pathway

Gene ◽  
2017 ◽  
Vol 628 ◽  
pp. 267-274
Author(s):  
Chaohui Dai ◽  
Haifei Wang ◽  
Guoqiang Zhu ◽  
Shenglong Wu ◽  
Wenbin Bao
Keyword(s):  
Immune Response ◽  
Gene Silencing ◽  
Signaling Pathway ◽  
Tlr4 Signaling ◽  
Tlr4 Signaling Pathway ◽  
Cd14 Gene
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