scholarly journals Cytochrome P450 2A6

2020 ◽  
Author(s):  
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 2A6

Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes

Xenobiotica ◽  
2009 ◽  
Vol 00 (00) ◽  
pp. 090901052053001-8
Author(s):  
K. Murai ◽  
H. Yamazaki ◽  
K. Nakagawa ◽  
R. Kawai ◽  
T. Kamataki
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Cytochrome P450 2A6

Associations of CYP2A6 Gene Polymorphism with Smoking Status Among Jordanians: Gender-Related Differences

2019 ◽  
Vol 20 (9) ◽  
pp. 765-770 ◽  
Author(s):  
Hana M. Hammad ◽  
Amer Imraish ◽  
Belal Azab ◽  
Al M. Best ◽  
Yousef S. Khader ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Genetic Polymorphism ◽  
Smoking Status ◽  
Hepatic Enzyme ◽  
Nicotine Metabolism ◽  
Significant Frequency ◽  
Cytochrome P450 2A6 ◽  
Study Population ◽  
Major Metabolic Pathway ◽  
Cyp2a6 Gene

Background: Cytochrome P450 2A6 enzyme (CYP2A6), an essential hepatic enzyme involved in the metabolism of drugs, is responsible for a major metabolic pathway of nicotine. Variation in the activity of polymorphic CYP2A6 alleles has been implicated in inter-individual differences in nicotine metabolism. Aims: The objective of the current study was to assess the association between the smoking status and the cytochrome P450 2A6 enzyme (CYP2A6) genotype in Jordanians. Methods: In the current study, 218 (117 Male and 101 female) healthy unrelated Jordanian volunteers were recruited. CYP2A6*1B, CYP2A6*4 and CYP2A6*9 were determined and correlated with subject smoking status. Results: *1A/*1A was the most common genetic polymorphism in the overall study population, with no significant frequency differences between smokers and non-smokers. When the population was divided according to gender, only male smokers showed a significant correlation between genotype and smoking status. Considering the CYP2A6*9 genotype, the results showed differences in distribution between smokers and non-smokers, but only women showed a significant association between CYP2A6*9 allele genotype and smoking status. Conclusion: The results of this study show that there is a significant association between CYP2A6*9 genotype and smoking status. They also show that CYP2A6 genotype is significantly influenced by gender.

Cytochrome P450 2A6 Phenotyping Based on Dietary Caffeine Intake in a Japanese Population of Non-smokers

2012 ◽  
Vol 6 (2) ◽  
pp. 67-72 ◽  
Author(s):  
Miyuki Kimura ◽  
Makiko Shimizu ◽  
Kazuma Kiyotani ◽  
Kazuko Nakagawa ◽  
Tetsuya Kamataki ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Japanese Population ◽  
Caffeine Intake ◽  
Cytochrome P450 2A6

scholarly journals Roles of cytochrome P450 2A6 in the oxidation of flavone, 4´-hydroxyflavone, and 4´-, 3´-, and 2´-methoxyflavones by human liver microsomes

Xenobiotica ◽  
2021 ◽  
pp. 1-47
Author(s):  
Haruna Nagayoshi ◽  
Norie Murayama ◽  
Shigeo Takenaka ◽  
Vitchan Kim ◽  
Donghak Kim ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cytochrome P450 2A6

scholarly journals Induction of Cytochrome P450 2A6 by Bilirubin in Human Hepatocytes

2013 ◽  
Vol 04 (02) ◽  
pp. 182-190 ◽  
Author(s):  
Hiromi Tanii ◽  
Yoshihisa Shitara ◽  
Mikako Torii ◽  
Shuichi Sekine ◽  
Hiroshi Iwata ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Hepatocytes ◽  
Cytochrome P450 2A6

Metabolism of bilirubin by human cytochrome P450 2A6

2012 ◽  
Vol 261 (1) ◽  
pp. 50-58 ◽  
Author(s):  
A'edah Abu-Bakar ◽  
Dionne M. Arthur ◽  
Anna S. Wikman ◽  
Minna Rahnasto ◽  
Risto O. Juvonen ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Cytochrome ◽  
Cytochrome P450 2A6 ◽  
Metabolism Of Bilirubin

scholarly journals Tumour suppressor protein p53 regulates the stress activated bilirubin oxidase cytochrome P450 2A6

2015 ◽  
Vol 289 (1) ◽  
pp. 30-39 ◽  
Author(s):  
Hao Hu ◽  
Ting Yu ◽  
Satu Arpiainen ◽  
Matti A. Lang ◽  
Jukka Hakkola ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Tumour Suppressor ◽  
Bilirubin Oxidase ◽  
Protein P53 ◽  
Tumour Suppressor Protein ◽  
Cytochrome P450 2A6

Differential inhibition of human cytochrome P450 2A6 and 2B6 by major phytocannabinoids

2011 ◽  
Vol 29 (2) ◽  
pp. 117-124 ◽  
Author(s):  
Satoshi Yamaori ◽  
Chikako Maeda ◽  
Ikuo Yamamoto ◽  
Kazuhito Watanabe
Keyword(s):  
Cytochrome P450 ◽  
Differential Inhibition ◽  
Human Cytochrome ◽  
Cytochrome P450 2A6

Exploring the structure characteristics and major channels of cytochrome P450 2A6, 2A13, and 2E1 with pilocarpine

Biopolymers ◽  
2018 ◽  
Vol 109 (4) ◽  
pp. e23108 ◽  
Author(s):  
Jing-Rong Fan ◽  
Heng Li ◽  
Hong-Xing Zhang ◽  
Qing-Chuan Zheng
Keyword(s):  
Cytochrome P450 ◽  
Structure Characteristics ◽  
Cytochrome P450 2A6
Sign in / Sign up

Export Citation Format

Share Document