scholarly journals Induction of Cytochrome P450 2A6 by Bilirubin in Human Hepatocytes

2013 ◽  
Vol 04 (02) ◽  
pp. 182-190 ◽  
Author(s):  
Hiromi Tanii ◽  
Yoshihisa Shitara ◽  
Mikako Torii ◽  
Shuichi Sekine ◽  
Hiroshi Iwata ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Hepatocytes ◽  
Cytochrome P450 2A6

Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes

Xenobiotica ◽  
2009 ◽  
Vol 00 (00) ◽  
pp. 090901052053001-8
Author(s):  
K. Murai ◽  
H. Yamazaki ◽  
K. Nakagawa ◽  
R. Kawai ◽  
T. Kamataki
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Cytochrome P450 2A6

Associations of CYP2A6 Gene Polymorphism with Smoking Status Among Jordanians: Gender-Related Differences

2019 ◽  
Vol 20 (9) ◽  
pp. 765-770 ◽  
Author(s):  
Hana M. Hammad ◽  
Amer Imraish ◽  
Belal Azab ◽  
Al M. Best ◽  
Yousef S. Khader ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Genetic Polymorphism ◽  
Smoking Status ◽  
Hepatic Enzyme ◽  
Nicotine Metabolism ◽  
Significant Frequency ◽  
Cytochrome P450 2A6 ◽  
Study Population ◽  
Major Metabolic Pathway ◽  
Cyp2a6 Gene

Background: Cytochrome P450 2A6 enzyme (CYP2A6), an essential hepatic enzyme involved in the metabolism of drugs, is responsible for a major metabolic pathway of nicotine. Variation in the activity of polymorphic CYP2A6 alleles has been implicated in inter-individual differences in nicotine metabolism. Aims: The objective of the current study was to assess the association between the smoking status and the cytochrome P450 2A6 enzyme (CYP2A6) genotype in Jordanians. Methods: In the current study, 218 (117 Male and 101 female) healthy unrelated Jordanian volunteers were recruited. CYP2A6*1B, CYP2A6*4 and CYP2A6*9 were determined and correlated with subject smoking status. Results: *1A/*1A was the most common genetic polymorphism in the overall study population, with no significant frequency differences between smokers and non-smokers. When the population was divided according to gender, only male smokers showed a significant correlation between genotype and smoking status. Considering the CYP2A6*9 genotype, the results showed differences in distribution between smokers and non-smokers, but only women showed a significant association between CYP2A6*9 allele genotype and smoking status. Conclusion: The results of this study show that there is a significant association between CYP2A6*9 genotype and smoking status. They also show that CYP2A6 genotype is significantly influenced by gender.

Cytochrome P450 2A6 Phenotyping Based on Dietary Caffeine Intake in a Japanese Population of Non-smokers

2012 ◽  
Vol 6 (2) ◽  
pp. 67-72 ◽  
Author(s):  
Miyuki Kimura ◽  
Makiko Shimizu ◽  
Kazuma Kiyotani ◽  
Kazuko Nakagawa ◽  
Tetsuya Kamataki ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Japanese Population ◽  
Caffeine Intake ◽  
Cytochrome P450 2A6

Effect of Pyrethrins on cytochrome P450 forms in cultured rat and human hepatocytes

Toxicology ◽  
2008 ◽  
Vol 243 (1-2) ◽  
pp. 84-95 ◽  
Author(s):  
Roger J. Price ◽  
Amanda M. Giddings ◽  
Mary P. Scott ◽  
David G. Walters ◽  
Charles C. Capen ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Hepatocytes

scholarly journals Roles of cytochrome P450 2A6 in the oxidation of flavone, 4´-hydroxyflavone, and 4´-, 3´-, and 2´-methoxyflavones by human liver microsomes

Xenobiotica ◽  
2021 ◽  
pp. 1-47
Author(s):  
Haruna Nagayoshi ◽  
Norie Murayama ◽  
Shigeo Takenaka ◽  
Vitchan Kim ◽  
Donghak Kim ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cytochrome P450 2A6

scholarly journals Peptide-based scaffolds for the culture and maintenance of primary human hepatocytes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Douglas MacPherson ◽  
Yaron Bram ◽  
Jiwoon Park ◽  
Robert E. Schwartz
Keyword(s):  
Cytochrome P450 ◽  
Human Hepatocytes ◽  
Peptide Ligand ◽  
3D Scaffold ◽  
Primary Human Hepatocytes ◽  
Peptide Component ◽  
Functional Peptide ◽  
Arginine Glycine Aspartic Acid ◽  
And Function ◽  
Cooperative Assembly

AbstractWe report here the use of a nanofibrous hydrogel as a 3D scaffold for the culture and maintenance of functional primary human hepatocytes. The system is based on the cooperative assembly of a fiber-forming peptide component, fluorenylmethyloxycarbonyl-diphenylalanine (Fmoc-FF), and the integrin-binding functional peptide ligand, Fmoc-arginine-glycine-aspartic acid (Fmoc-RGD) into a nanofibrous gel at physiological pH. This Fmoc-FF/RGD hydrogel was formulated to provide a biomimetic microenvironment with some critical features such as mechanical properties and nanofiber morphology, which were optimized to support hepatocyte culture. The material was shown to support maintenance and function of encapsulated primary human hepatocytes as indicated by actin staining, qRT-PCR, and functional cytochrome P450 assays. The designed gel was shown to outperform Matrigel in cytochrome P450 functional assays. The hydrogel may prove useful for liver development and disease models, as well as providing insights into the design of future implantable scaffolds for the regeneration of liver tissue in patients with liver disease.

Plateable cryopreserved human hepatocytes for the assessment of cytochrome P450 inducibility: experimental condition-related variables affecting their response to inducers

Xenobiotica ◽  
2012 ◽  
Vol 42 (10) ◽  
pp. 968-979 ◽  
Author(s):  
Eliane Alexandre ◽  
Audrey Baze ◽  
Céline Parmentier ◽  
Coraline Desbans ◽  
Dumrongsak Pekthong ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Hepatocytes
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