scholarly journals Radioimmunoguided Surgery

2020 ◽  
Author(s):  
Keyword(s):  
Radioimmunoguided Surgery

Benefits of radioimmunoguided surgery for pelvic recurrence

2001 ◽  
Vol 27 (3) ◽  
pp. 298-301 ◽  
Author(s):  
R. Haddad ◽  
S. Avital ◽  
A. Troitsa ◽  
J. Chen ◽  
M. Baratz ◽  
...  
Keyword(s):  
Pelvic Recurrence ◽  
Radioimmunoguided Surgery

Radioimmunoguided surgery in primary colorectal carcinoma: An intraoperative prognostic tool and adjuvant to traditional staging

1995 ◽  
Vol 170 (4) ◽  
pp. 315-318 ◽  
Author(s):  
Mark W. Arnold ◽  
Donn C. Young ◽  
Charles L. Hitchcock ◽  
Schlomo Schneebaum ◽  
Edward W. Martin
Keyword(s):  
Colorectal Carcinoma ◽  
Radioimmunoguided Surgery ◽  
Prognostic Tool

Radioimmunoguided surgery after primary treatment of locally advanced breast cancer.

1996 ◽  
Vol 14 (5) ◽  
pp. 1599-1603 ◽  
Author(s):  
P Percivale ◽  
S Bertoglio ◽  
P Meszaros ◽  
G Canavese ◽  
F Cafiero ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Primary Tumor ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Advanced Breast ◽  
Primary Chemotherapy ◽  
Radioimmunoguided Surgery ◽  
Group A ◽  
Group B

PURPOSE To assess the role of radioimmunoguided surgery (RIGS) using a handheld intraoperative gamma-detecting probe (GDP) to identify neoplastic disease after primary chemotherapy in locally advanced breast cancer (LABC) patients injected with iodine 125-labeled monoclonal antibodies (MAbs). PATIENTS AND METHODS Twenty-one patients with histologically documented LABC were treated with a combined modality approach. After three courses of primary chemotherapy and before modified radical mastectomy, the 125I-radiolabeled MAbs B72.3 (anti-TAG72) and FO23C5 (anti-carcinoembryonic antigen [CEA]) were administered to 11 patients (group A) and 10 patients (group B), respectively. At surgery, a GDP was used to locate the primary tumor and to assess possible tumor multicentricity and the presence of ipsilateral axillary metastases. Routine pathologic examination was performed in neoplastic and normal tissue specimens of all 21 patients. In addition, immunohistochemical assay for TAG72 and CEA expression was performed. RESULTS In group A patients, RIGS identified primary tumor in seven of 11 patients (63.3%) and unpalpable multicentric tumor lesions were located in two of four (50%). Positive axillary lymph nodes were histologically documented in eight of 11 patients (72.7%) and RIGS identified three of eight (37.5%). In group B, RIGS located the primary tumor lesion in four of 10 patients (40%); in two cases, the tumor was not clinically evident. Multicentricity was observed in one of two patients and lymph node involvement in three of nine (33.3%). No false-positive results were observed in either group A or B. CONCLUSION RIGS appears to be a safe and reliable technique. However, the MAbs used in this study are not sufficiently specific. RIGS represents a technique for which the full potential for intraoperative assessment of breast cancer lesions can be reached when more specific antibodies become readily available.

Radioimmunoguided surgery for recurrent colorectal cancer manifested by isolated CEA elevation

1999 ◽  
Vol 35 ◽  
pp. S76
Author(s):  
S. Avital ◽  
R. Haddad ◽  
A. Troitsa ◽  
H. Kashtan ◽  
E. Brazovsky ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Recurrent Colorectal Cancer ◽  
Radioimmunoguided Surgery

Assessment of disseminated pancreatic cancer: A comparison of traditional exploratory laparotomy and radioimmunoguided surgery

Surgery ◽  
1997 ◽  
Vol 122 (5) ◽  
pp. 867-873 ◽  
Author(s):  
Gregory J LaValle ◽  
Deborah A Martinez ◽  
Denise Sobel ◽  
Barry DeYoung ◽  
Edward W Martin
Keyword(s):  
Pancreatic Cancer ◽  
Exploratory Laparotomy ◽  
Radioimmunoguided Surgery
Sign in / Sign up

Export Citation Format

Share Document