Enhancement of colorectal tumor targeting using a novel biparatopic monoclonal antibody against carcinoembryonic antigen in experimental radioimmunoguided surgery

2002 ◽  
Vol 97 (4) ◽  
pp. 542-547 ◽  
Author(s):  
Jin C. Kim ◽  
Seon A. Roh ◽  
Kum H. Koo ◽  
Jang H. Ryu ◽  
Hyun K. Hong ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Carcinoembryonic Antigen ◽  
Tumor Targeting ◽  
Colorectal Tumor ◽  
Radioimmunoguided Surgery

scholarly journals Clinical evaluation of tumor targeting with the anticarcinoembryonic antigen murine monoclonal antibody fragment, MN-14 F(ab)2

Cancer ◽  
1996 ◽  
Vol 78 (1) ◽  
pp. 157-168 ◽  
Author(s):  
Malik Juweid ◽  
Robert M. Sharkey ◽  
Thomas M. Behr ◽  
Lawrence C. Swayne ◽  
Robert Dunn ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Clinical Evaluation ◽  
Tumor Targeting ◽  
Antibody Fragment ◽  
Murine Monoclonal Antibody

Tumor targeting therapy using peplomycin-conjugated ST433 monoclonal antibody in nude mice

1988 ◽  
Vol 10 ◽  
pp. 30
Author(s):  
K. Shibuya ◽  
T. Someno ◽  
F. Abe ◽  
T. Setoh ◽  
S. Fukushima ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Nude Mice ◽  
Tumor Targeting ◽  
Targeting Therapy

RADIOIMMUNOIMAGING OF TUMORS WITH INDIUM-111 LABELED F(abʼ)2 ANTI-CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY.

1986 ◽  
Vol 11 (Supplement) ◽  
pp. P14
Author(s):  
Walter Haindl ◽  
Samuel E. Halpern ◽  
Robert O. Dillman ◽  
Phillip L. Hagan ◽  
Jacquelyn Beauregard ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Carcinoembryonic Antigen ◽  
Indium 111

scholarly journals Highly sensitive biomarker biosensor for early detection of cancer biomarkers

2021 ◽  
Author(s):  
Jaydev Upponi ◽  
Tiziana Musacchio ◽  
Salome Siavoshi ◽  
Asanterabi Malima ◽  
Cihan Yilmaz ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Early Detection ◽  
Carcinoembryonic Antigen ◽  
Early Detection Of Cancer ◽  
Cancer Biomarkers ◽  
Diagnostic Tools ◽  
Detection Systems ◽  
Highly Sensitive ◽  
Current Detection ◽  
Insufficient Sensitivity

Abstract Biomarkers are emerging as potentially important diagnostic tools for cancer and many other diseases. However, many current detection systems for suffer from insufficient sensitivity. To address this concern, we developed a highly sensitive biosensor, featuring monoclonal antibody-coated polystyrene nanobeads assembled in the trenches of a microchip, for the detection of cancer biomarkers. These biosensors detected nucleosomes and carcinoembryonic antigen in serum at concentrations of 62.5 and 15.6 pg/mL, respectively. Very low detection limits that suggest such devices might be beneficial for the early detection of tumors and for monitoring of patients in remission.

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