scholarly journals Frontal Lobe and Parietal Lobe Ependymal Tumor

2020 ◽  
Author(s):  
Keyword(s):  
Frontal Lobe ◽  
Parietal Lobe ◽  
Ependymal Tumor

An explainable Artificial Intelligence approach to study MCI to AD conversion via HD-EEG processing

2021 ◽  
pp. 155005942110636
Author(s):  
Francesco Carlo Morabito ◽  
Cosimo Ieracitano ◽  
Nadia Mammone
Keyword(s):  
Artificial Intelligence ◽  
Frontal Lobe ◽  
Parietal Lobe ◽  
Classification Performance ◽  
Head Region ◽  
Left Frontal Lobe ◽  
Performance Accuracy ◽  
Power Spectral ◽  
Explainable Artificial Intelligence

An explainable Artificial Intelligence (xAI) approach is proposed to longitudinally monitor subjects affected by Mild Cognitive Impairment (MCI) by using high-density electroencephalography (HD-EEG). To this end, a group of MCI patients was enrolled at IRCCS Centro Neurolesi Bonino Pulejo of Messina (Italy) within a follow-up protocol that included two evaluations steps: T0 (first evaluation) and T1 (three months later). At T1, four MCI patients resulted converted to Alzheimer’s Disease (AD) and were included in the analysis as the goal of this work was to use xAI to detect individual changes in EEGs possibly related to the degeneration from MCI to AD. The proposed methodology consists in mapping segments of HD-EEG into channel-frequency maps by means of the power spectral density. Such maps are used as input to a Convolutional Neural Network (CNN), trained to label the maps as “T0” (MCI state) or “T1” (AD state). Experimental results reported high intra-subject classification performance (accuracy rate up to 98.97% (95% confidence interval: 98.68–99.26)). Subsequently, the explainability of the proposed CNN is explored via a Grad-CAM approach. The procedure allowed to detect which EEG-channels (i.e., head region) and range of frequencies (i.e., sub-bands) resulted more active in the progression to AD. The xAI analysis showed that the main information is included in the delta sub-band and that, limited to the analyzed dataset, the highest relevant areas are: the left-temporal and central-frontal lobe for Sb01, the parietal lobe for Sb02, the left-frontal lobe for Sb03 and the left-frontotemporal region for Sb04.

scholarly journals IMAGING OF INTRACRANIAL SPACE OCCUPYING LESIONS

2021 ◽  
Vol 5 (11) ◽  
Author(s):  
Saroj Kumari ◽  
Raghav Kumar
Keyword(s):  
Frontal Lobe ◽  
Parietal Lobe ◽  
Clinical Suspicion ◽  
Diverse Group ◽  
Resonance Imaging ◽  
Common Location ◽  
Intracranial Lesions ◽  
Anatomical Detail ◽  
Scanning Imaging ◽  
Clinical Departments

Introduction: With advanced MRI techniques such as perfusion, diffusion, and spectroscopy, it is now possible to differentiate between various intracranial lesions. Materials and Methods: This prospective cohort study was conducted on 50 patients referred by various clinical departments with clinical suspicion of intracranial space occupying lesions, evaluated by computed tomography & magnetic resonance imaging. Result: Solitary lesions were present in 35 patients (70%) & multiple lesions in 15 patients (30%). 68.00% lesions were Supratentorial & 32.00% infratentorial in location. Most common supratentorial location in adults was frontal lobe 40% followed by parietal lobe 30%. Most common supratentorial locations in children were frontal lobe. Infratentorially, cerebellum & posterior fossa were found to be most common location in adults & children respectively. Supratentorial lesions were most common both in adults & children. 60% lesions were intraaxial & 40 % extra axial in location. In adults, intraaxial lesions were more common than in children. Conclusion: Intracranial space occupying lesions comprise of a diverse group of lesions. With the introduction of CT & MRI scanning, imaging of lesions has acquired a new dimension whereby excellent anatomical detail in axial, sagittal & coronal planes as well as lesion characterization has become possible. Key words: Brain, CT, MRIs

Post-Stimulation Effect of Electroacupuncture at Yintang (EX-HN3) and GV20 on cerebral functional regions in healthy volunteers: A resting functional MRI study

2012 ◽  
Vol 30 (4) ◽  
pp. 307-315 ◽  
Author(s):  
Yu Zheng ◽  
Shanshan Qu ◽  
Na Wang ◽  
Limin Liu ◽  
Guanzhong Zhang ◽  
...  
Keyword(s):  
Frontal Lobe ◽  
Temporal Lobe ◽  
Parietal Lobe ◽  
Occipital Lobe ◽  
Cingulate Gyrus ◽  
Left Frontal Lobe ◽  
Posterior Cingulate Gyrus ◽  
Functional Regions ◽  
Limbic Lobe ◽  
The Right

Objective The aim of the present work was to observe the activation/deactivation of cerebral functional regions after electroacupuncture (EA) at Yintang (EX-HN3) and GV20 by functional MRI (fMRI). Design A total of 12 healthy volunteers were stimulated by EA at Yintang and GV20 for 30 min. Resting-state fMRI scans were performed before EA, and at 5 and 15 min after needle removal. Statistical parametric mapping was used to preprocess initial data, and regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) were analysed. Results ReHo at 5 min post stimulation showed increases in the left temporal lobe and cerebellum and decreases in the left parietal lobe, occipital lobe and right precuneus. At 15 min post stimulation, ReHo showed increases in the left fusiform gyrus; lingual gyrus; middle temporal gyrus; postcentral gyrus; limbic lobe; cingulate gyrus; paracentral lobule; cerebellum, posterior lobe, declive; right cuneus and cerebellum, anterior lobe, culmen. It also showed decreases in the left frontal lobe, parietal lobe, right temporal lobe, frontal lobe, parietal lobe and right cingulate gyrus. ALFF at 5 min post stimulation showed increases in the right temporal lobe, but decreases in the right limbic lobe and posterior cingulate gyrus. At 15 min post stimulation ALFF showed increases in the left frontal lobe, parietal lobe, occipital lobe, right temporal lobe, parietal lobe, occipital lobe and cerebellum, but decreases in the left frontal lobe, anterior cingulate gyrus, right frontal lobe and posterior cingulate gyrus. Conclusions After EA stimulation at Yintang and GV20, which are associated with psychiatric disorder treatments, changes were localised in the frontal lobe, cingulate gyrus and cerebellum. Changes were higher in number and intensity at 15 min than at 5 min after needle removal, demonstrating lasting and strong after-effects of EA on cerebral functional regions.

scholarly journals Stable complexes of neuropsychiatric symptoms in patients with vascular dementia with different localization of brain pathological focuses

2020 ◽  
pp. 44-50
Author(s):  
Oleksandr Zlobin
Keyword(s):  
Vascular Dementia ◽  
Frontal Lobe ◽  
Temporal Lobe ◽  
Sleep Disturbances ◽  
Parietal Lobe ◽  
Neuropsychiatric Symptoms ◽  
Occipital Lobe ◽  
Pathological Process ◽  
Therapeutic Interventions ◽  
Affective Symptoms

The aim of the study was to determine the stable complexes of neuropsychiatric symptoms inherent in patients with vascular dementia with different localization of brain damage. 157 people with a diagnosis of vascular dementia were examined. Group 1 included 22 people with localization of the pathological process in the frontal lobe, group 2 — 18 patients with lesions of the temporal lobe, group 3 — 17 patients with lesions of the parietal lobe, group 4 — 15 patients with lesions of the occipital lobe, group 5 — 68 people with total defeat. All contingents are post-stroke patients over 50 years old, the average age is 68.12 years. Research methods: clinical-psychopathological, clinical-instrumental, experimental-psychological, anamnestic, clinical-statistical. The stable complexes (clusters) of neuropsychiatric symptoms inherent in patients with vascular dementia with different localization of brain lesions were determined. Revealing the following stable associations “localization — cluster”: frontal lobe — subpsychotic cluster (delusion — hallucinations — euphoria — agitation — depression); temporal lobe — asthenoanxiotic cluster (anxiety — irritability — agitation — sleep disturbances — apathy); parietal lobe — excitable-depressive cluster (depression — agitation — irritability — sleep disturbances); occipital lobe — affectocentric cluster (anxiety — depression — agitation — irritability); total defeat — asthenopathoideatoric cluster (apathy — irritability — agitation — anxiety — delirium). The identification of the association allows one to confidently determine the nature of the expected neuropsychiatric symptoms immediately after obtaining neuroimaging data regarding the localization of the lesion, which creates optimal conditions for the timely formation of a program of appropriate therapeutic interventions. Key words: vascular dementia, psychopathology, affective symptoms, neuropsychiatric symptoms, geriatric psychiatry

scholarly journals A Meta-Analysis of Alzheimer’s Disease Brain Transcriptomic Data

2018 ◽  
Author(s):  
Hamel Patel ◽  
Richard J.B Dobson ◽  
Stephen J Newhouse
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Frontal Lobe ◽  
Temporal Lobe ◽  
Parietal Lobe ◽  
Meta Analysis ◽  
Differential Expression Analysis ◽  
Brain Regions ◽  
Biological Pathways ◽  
Transcriptomic Changes

ABSTRACTBackgroundMicroarray technologies have identified imbalances in the expression of specific genes and biological pathways in Alzheimer’s disease (AD) brains. However, there is a lack of reproducibility across individual AD studies, and many related neurodegenerative and mental health disorders exhibit similar perturbations. We are yet to identify robust transcriptomic changes specific to AD brains.Methods and ResultsTwenty-two AD, eight Schizophrenia, five Bipolar Disorder, four Huntington's disease, two Major Depressive Disorder and one Parkinson’s disease dataset totalling 2667 samples and mapping to four different brain regions (Temporal lobe, Frontal lobe, Parietal lobe and Cerebellum) were analysed. Differential expression analysis was performed independently in each dataset, followed by meta-analysis using a combining p-value method known as Adaptively Weighted with One-sided Correction. This identified 323, 435, 1023 and 828 differentially expressed genes specific to the AD temporal lobe, frontal lobe, parietal lobe and cerebellum brain regions respectively. Seven of these genes were consistently perturbed across all AD brain regions with SPCS1 gene expression pattern replicating in RNA-seq data. A further nineteen genes were perturbed specifically in AD brain regions affected by both plaques and tangles, suggesting possible involvement in AD neuropathology. Biological pathways involved in the “metabolism of proteins” and viral components were significantly enriched across AD brains.ConclusionThis study solely relied on publicly available microarray data, which too often lacks appropriate phenotypic information for robust data analysis and needs to be addressed by future studies. Nevertheless, with the information available, we were able to identify specific transcriptomic changes in AD brains which could make a significant contribution towards the understanding of AD disease mechanisms and may also provide new therapeutic targets.

scholarly journals A-249 Evidence for Frontal Lobe Involvement in the Visual Processing Streams

2020 ◽  
Vol 35 (6) ◽  
pp. 1044-1044
Author(s):  
Leonard S ◽  
Hall T
Keyword(s):  
Frontal Lobe ◽  
Visual Processing ◽  
Visual Memory ◽  
Word Reading ◽  
Parietal Lobe ◽  
Occipital Lobe ◽  
Current Case ◽  
Verbal Skills ◽  
Orbital Roof ◽  
Visual Spatial

Abstract Objective Extant literature supports the “Two-Stream Hypothesis” of visual processing including a ventral stream (connecting the occipital lobe to the temporal lobe) and a dorsal stream (connecting the occipital lobe to the parietal lobe), but is not traditionally believed to involve the frontal lobe. Method “Eddie”, a healthy 14-year-old male, sustained a penetrating brain injury by accidentally lodging a pool cue through his right orbital bones and piercing his right frontal lobe through to the skull. He was ambulatory, awake, and alert on arrival to the ED, with a laceration, swelling, and bleeding of the eyelid. A cranial CT revealed a complex orbital roof fracture, injury to the orbit, and right frontal contusions. Eddie underwent a right supraorbital craniotomy with repair of the orbital roof fracture and debridement of bony fragments. Post-operative MRI revealed right frontal parenchymal edema and patchy areas of contusion. Results Neuropsychological evaluation revealed a robust cognitive reserve including verbal skills, working memory, processing speed, and word reading skills in the high average. Eddie demonstrated significant discrepancies in visually mediated skills including relatively weaker visual–spatial skills (24 standard score (SS) points lower than verbal skills), fluid reasoning with visual problem-solving (30 SS points lower than verbal skills), low average judgment of line orientation, and a discrepancy between verbal and visual memory. He also demonstrated mild difficulties consistent with his right orbito-frontal injury including weaknesses regarding impulsivity, self-monitoring, planning, and task approach. Conclusions The current case demonstrates possible involvement of the frontal lobe in the visual processing pathways.

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