scholarly journals Heptanoic Acid

2020 ◽  
Author(s):  
Keyword(s):  
Heptanoic Acid

The Filter Loop Technique as a Method of Measuring Platelet Aggregation in the Flowing Blood of the Rat; the Inhibitory Activity of 5-oxo-l-cyclopentene-l-heptanoic Acid (AY-16,804) on Platelet Aggregation

1973 ◽  
Vol 30 (01) ◽  
pp. 138-147 ◽  
Author(s):  
Christopher R. Muirhead
Keyword(s):  
Platelet Aggregation ◽  
Prostaglandin E1 ◽  
Suitable Model ◽  
Heptanoic Acid ◽  
Simple Method ◽  
Loop Technique ◽  
Flowing Blood ◽  
Filter Loop

SummaryThe filter loop technique which measures platelet aggregation in vivo in the flowing-blood of the rat was compared to the optical density technique of Born which is carried out in vitro with platelet rich plasma. Using these two experimental models the effect on platelet aggregation of three known inhibitors sulfinpyrazone, dipyridamole and prostaglandin E1, and a novel compound 5-oxo-l-cyclopentene-l-heptanoic acid (AY-16, 804) was determined.The effects on platelet aggregation of the known inhibitors were consistent with information in the literature. Prostaglandin E1 was the most potent inhibitor in both techniques; sulfinpyrazone inhibited aggregation in both models but was less potent than prostaglandin E1. AY-16, 804 exhibited activity in vitro and in vivo similar to that of sulfinpyrazone. Dipyridamole did not inhibit platelet aggregation in vivo and did not inhibit aggregation in vitro in concentrations at which it remained soluble.The filter loop technique is a suitable model for measuring platelet aggregation in the flowing blood of the rat. It is a relatively simple method of determining aggregation and easily adapted to other species.

Solution concentration controlled self-assembling structure with host–guest recognition at the liquid–solid interface

2015 ◽  
Vol 17 (37) ◽  
pp. 24462-24467 ◽  
Author(s):  
Siqi Zhang ◽  
Junyong Zhang ◽  
Ke Deng ◽  
Jingli Xie ◽  
Wubiao Duan ◽  
...  
Keyword(s):  
Solution Concentration ◽  
Heptanoic Acid ◽  
Structural Variety ◽  
Solid Interface ◽  
Self Assembling

This work describes structural variety in the co-assembly of H3TTCA/COR controlled by the solution concentration of COR at the 1-heptanoic acid/HOPG interface.

7-(Disubstituted thiazolyl)-3,5-dihydroxy-6-heptenoic/heptanoic acid derivatives as HMG-COa reductase inhibitors

1994 ◽  
Vol 2 (8) ◽  
pp. 799-806
Author(s):  
Violetta Cecchetti ◽  
Amaldo Fravolini ◽  
Pier Giuseppe Pagella ◽  
Oriana Tabarrini ◽  
Andrea Temperini
Keyword(s):  
Heptanoic Acid ◽  
Hmg Coa Reductase ◽  
Reductase Inhibitors ◽  
Hmg Coa Reductase Inhibitors ◽  
Coa Reductase

scholarly journals Establishment of a Gastric Cell-Based Assay System for Exploring Inhibitors of Octanoylated Ghrelin Production

2013 ◽  
Vol 18 (9) ◽  
pp. 1035-1042 ◽  
Author(s):  
Shigeru Oiso ◽  
Miyuki Nobe ◽  
Yuhei Yamaguchi ◽  
Shigeru Umemoto ◽  
Kazuo Nakamura ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Butyric Acid ◽  
Posttranslational Modification ◽  
Culture Medium ◽  
Octanoic Acid ◽  
Assay System ◽  
Heptanoic Acid ◽  
Ags Cells ◽  
Gastric Cell ◽  
Low Levels

Ghrelin, a gastric hormone, is a growth hormone-releasing peptide. Its serine-3 acylation with octanoic acid is essential for its orexigenic activity, and therefore, inhibition of the acylation of ghrelin may help in decreasing appetite and preventing obesity. This study aimed to establish a human gastric cell-based assay system to evaluate candidate inhibitors of octanoylated ghrelin production. In human gastric carcinoma AGS cells, obligatory factors for the posttranslational modification of ghrelin, such as certain prohormone convertases responsible for processing of proghrelin to the mature ghrelin and the enzyme-catalyzing acyl-modification of ghrelin, were well expressed, but ghrelin was expressed at low levels. Accordingly, we transfected a ghrelin-expressing vector into AGS cells and isolated a stable ghrelin-expressing cell line (AGS-GHRL8). AGS-GHRL8 cells secreted octanoylated ghrelin in accordance with the concentrations of octanoic acid in the culture medium. Given that ingested heptanoic acid is used for the acyl-modification of ghrelin, we evaluated whether heptanoic acid inhibits production of octanoylated ghrelin in AGS-GHRL8 cells. Butyric acid was used as a control. Indeed, heptanoic acid predictably decreased the secretion of octanoylated ghrelin, whereas butyric acid did not. The AGS-GHRL8 line established in this study will facilitate the screening of inhibitors of octanoylated ghrelin production.

Reactivity and stability of supported Pd nanoparticles during the liquid-phase and gas-phase decarbonylation of heptanoic acid

2015 ◽  
Vol 504 ◽  
pp. 295-307 ◽  
Author(s):  
Juan A. Lopez-Ruiz ◽  
Hien N. Pham ◽  
Abhaya K. Datye ◽  
Robert J. Davis
Keyword(s):  
Liquid Phase ◽  
Gas Phase ◽  
Pd Nanoparticles ◽  
Heptanoic Acid ◽  
Supported Pd

scholarly journals Impact of Drying Method on the Evaluation of Fatty Acids and Their Derived Volatile Compounds in ‘Thompson Seedless’ Raisins

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 608 ◽  
Author(s):  
Dong Wang ◽  
Hafiz Umer Javed ◽  
Ying Shi ◽  
Safina Naz ◽  
Sajid Ali ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Principal Component Analysis ◽  
Volatile Compounds ◽  
Unsaturated Fatty Acids ◽  
Saturated Fatty Acids ◽  
Principal Component ◽  
Heptanoic Acid ◽  
Drying Method ◽  
Thompson Seedless ◽  
Air Drying

Air- and sun-dried raisins from Thompson Seedless (TS) grapes were analyzed under GC/MS to evaluate fatty acids (FAs) and their derived volatile compounds, coming from unsaturated fatty acids oxidation. A total of 16 FAs were identified in TS raisins, including 10 saturated fatty acids (SFAs) and 6 unsaturated fatty acids (USFAs). The contents of C18:0, C15:0, and C16:0 among SFAs and C18:3, C18:2 and C18:1 in USFAs were significantly higher. Furthermore, USFAs such as C16:1 and C20:1 were only identified in air-dried raisins. The principal component analysis showed the increased content of FAs and FA-derived compounds were in air-dried and sun-dried raisins, respectively. Among FA-derived compounds, 2-pentyl furan, 3-octen-2-one, 1-hexanol and heptanoic acid were more potent. This study shows that air-drying is more favorable for the production of fatty acids (SFAs and USFAs), whereas sun-drying is more advantageous in terms of fatty acid-derived volatiles.

Characterization of the Phase Behavior and Complexation in the Heptanoic Acid−Heptylamine−Water System

2001 ◽  
Vol 105 (33) ◽  
pp. 7944-7949 ◽  
Author(s):  
Stefan Karlsson ◽  
Juha Päivärinta ◽  
Rauno Friman ◽  
Antti Poso ◽  
Matti Hotokka ◽  
...  
Keyword(s):  
Phase Behavior ◽  
Water System ◽  
Heptanoic Acid

scholarly journals Flexible polyurethanes, renewable fuels, and flavorings from a microalgae oil waste stream

2020 ◽  
Vol 22 (10) ◽  
pp. 3088-3094 ◽  
Author(s):  
Thien An Phung Hai ◽  
Nitin Neelakantan ◽  
Marissa Tessman ◽  
Suryendra D. Sherman ◽  
Graham Griffin ◽  
...  
Keyword(s):  
Polyurethane Foam ◽  
Azelaic Acid ◽  
Waste Stream ◽  
Renewable Fuels ◽  
Heptanoic Acid ◽  
Microalgae Oil ◽  
Flexible Polyurethane Foam ◽  
Algae Oil ◽  
Flexible Polyurethane

To achieve sustainably-sourced polymers from algae, azelaic acid was prepared from an algae oil waste stream and converted into a flexible polyurethane foam. The heptanoic acid co-product was converted into both a flavoring and a renewable solvent.

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