scholarly journals Cysteine Peptidase Gene

2020 ◽  
Author(s):  
Keyword(s):  
Cysteine Peptidase

Cysteine Peptidase Inhibitors in Trypanosomatid Parasites

2013 ◽  
Vol 20 (25) ◽  
pp. 3152-3173 ◽  
Author(s):  
A. Lima ◽  
F. Reis ◽  
T. Costa
Keyword(s):  
Peptidase Inhibitors ◽  
Cysteine Peptidase ◽  
Trypanosomatid Parasites

scholarly journals Recombinant expression and characterization of a cysteine peptidase from Xanthomonas citri subsp citri

2012 ◽  
Vol 11 (4) ◽  
pp. 4043-4057 ◽  
Author(s):  
A. Soares-Costa ◽  
R.S. Silveira ◽  
M.T.M. Novo ◽  
M.F.M. Alves ◽  
A.K. Carmona ◽  
...  
Keyword(s):  
Recombinant Expression ◽  
Xanthomonas Citri ◽  
Cysteine Peptidase

scholarly journals Identification of Lead Compounds Targeting the Cathepsin B-Like Enzyme of Eimeria tenella

2011 ◽  
Vol 56 (3) ◽  
pp. 1190-1201 ◽  
Author(s):  
Marie Schaeffer ◽  
Joerg Schroeder ◽  
Anja R. Heckeroth ◽  
Sandra Noack ◽  
Michael Gassel ◽  
...  
Keyword(s):  
Cathepsin B ◽  
Biochemical Characterization ◽  
Single Copy ◽  
Eimeria Tenella ◽  
Genome Database ◽  
Content Type ◽  
Cysteine Peptidase ◽  
Peptidase Inhibitor ◽  
Mature Enzyme ◽  
Novel Drug

ABSTRACTCysteine peptidases have been implicated in the development and pathogenesis ofEimeria. We have identified a single-copy cathepsin B-like cysteine peptidase gene in the genome database ofEimeria tenella(EtCatB). Molecular modeling of the predicted protein suggested that it differs significantly from host enzymes and could be a good drug target. EtCatB was expressed and secreted as a soluble, active, glycosylated mature enzyme fromPichia pastoris. Biochemical characterization of the recombinant enzyme confirmed that it is cathepsin B-like. Screening of a focused library against the enzyme identified three inhibitors (a nitrile, a thiosemicarbazone, and an oxazolone) that can be used as leads for novel drug discovery againstEimeria. The oxazolone scaffold is a novel cysteine peptidase inhibitor; it may thus find widespread use.

scholarly journals Probing the Activity Modification Space of the Cysteine Peptidase Cathepsin K with Novel Allosteric Modifiers

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e106642 ◽  
Author(s):  
Marko Novinec ◽  
Brigita Lenarčič ◽  
Antonio Baici
Keyword(s):  
Cathepsin K ◽  
Cysteine Peptidase

scholarly journals Inhibitor of Cysteine Peptidase Does Not Influence the Development of Leishmania mexicana in Lutzomyia longipalpis

2009 ◽  
Vol 46 (3) ◽  
pp. 605-609 ◽  
Author(s):  
Lucie Jecna ◽  
Anna Svarovska ◽  
Sebastien Besteiro ◽  
Jeremy C. Mottram ◽  
Graham H. Coombs ◽  
...  
Keyword(s):  
Lutzomyia Longipalpis ◽  
Leishmania Mexicana ◽  
Cysteine Peptidase

scholarly journals The Structure ofLeishmania mexicanaICP Provides Evidence for Convergent Evolution of Cysteine Peptidase Inhibitors

2005 ◽  
Vol 281 (9) ◽  
pp. 5821-5828 ◽  
Author(s):  
Brian O. Smith ◽  
Nichola C. Picken ◽  
Gareth D. Westrop ◽  
Krystyna Bromek ◽  
Jeremy C. Mottram ◽  
...  
Keyword(s):  
Convergent Evolution ◽  
Peptidase Inhibitors ◽  
Cysteine Peptidase

scholarly journals Cysteine Peptidase B Regulates Leishmania mexicana Virulence through the Modulation of GP63 Expression

2016 ◽  
Vol 12 (5) ◽  
pp. e1005658 ◽  
Author(s):  
Pierre-André Casgrain ◽  
Caroline Martel ◽  
W. Robert McMaster ◽  
Jeremy C. Mottram ◽  
Martin Olivier ◽  
...  
Keyword(s):  
Leishmania Mexicana ◽  
Cysteine Peptidase
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