scholarly journals American trypanosomiasis

2020 ◽  
Author(s):  
Keyword(s):  
American Trypanosomiasis

Major Kinds of Drug Targets in Chagas Disease or American Trypanosomiasis

2019 ◽  
Vol 20 (11) ◽  
pp. 1203-1216 ◽  
Author(s):  
Vilma G. Duschak
Keyword(s):  
Chagas Disease ◽  
Latin American ◽  
Drug Targets ◽  
Defense Mechanisms ◽  
Cysteine Proteinase ◽  
Parasitic Infection ◽  
Etiologic Agent ◽  
World Health ◽  
American Trypanosomiasis ◽  
Group I

American Trypanosomiasis, a parasitic infection commonly named Chagas disease, affects millions of people all over Latin American countries. Presently, the World Health Organization (WHO) predicts that the number of international infected individuals extends to 7 to 8 million, assuming that more than 10,000 deaths occur annually. The transmission of the etiologic agent, Trypanosoma cruzi, through people migrating to non-endemic world nations makes it an emergent disease. The best promising targets for trypanocidal drugs may be classified into three main groups: Group I includes the main molecular targets that are considered among specific enzymes involved in the essential processes for parasite survival, principally Cruzipain, the major antigenic parasite cysteine proteinase. Group II involves biological pathways and their key specific enzymes, such as Sterol biosynthesis pathway, among others, specific antioxidant defense mechanisms, and bioenergetics ones. Group III includes the atypical organelles /structures present in the parasite relevant clinical forms, which are absent or considerably different from those present in mammals and biological processes related to them. These can be considered potential targets to develop drugs with extra effectiveness and fewer secondary effects than the currently used therapeutics. An improved distinction between the host and the parasite targets will help fight against this neglected disease.

Chagas's Disease (South American Trypanosomiasis)

1971 ◽  
Vol 57 (5) ◽  
pp. 966
Author(s):  
Robert G. Yaeger ◽  
M. A. Miles ◽  
Jean E. Rouse
Keyword(s):  
South American ◽  
American Trypanosomiasis

scholarly journals American trypanosomiasis (Chagas' disease) in conventional and germfree rats and mice

1987 ◽  
Vol 29 (5) ◽  
pp. 284-288 ◽  
Author(s):  
Marcelo E. Silva ◽  
Elizio A. Evangelista ◽  
Jacques R. Nicoli ◽  
Eduardo A. Bambirra ◽  
Enio C. Vieira
Keyword(s):  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Cardiac Failure ◽  
Sprague Dawley ◽  
American Trypanosomiasis ◽  
Sprague Dawley Rats ◽  
Rats And Mice ◽  
Germfree Rats

Germfree (GF) and conventional (CV) CFW (LOB) mice and Wistar and Sprague-Dawley rats were infected with Trypanosoma cruzi. The disease was more severe in the GF than in the CV animals as revealed by: (1) an earlier and more intense parasitemia; (2) a more precocious mortality; (3) a twice enlarged spleen: (4) a more intense cell and tissue parasitism; (5) visceral signs of cardiac failure.

American Trypanosomiasis (Chagas Disease)

2012 ◽  
Vol 26 (2) ◽  
pp. 275-291 ◽  
Author(s):  
Anis Rassi ◽  
Anis Rassi ◽  
Joffre Marcondes de Rezende
Keyword(s):  
Chagas Disease ◽  
American Trypanosomiasis
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