scholarly journals Mead Acid

2020 ◽  
Author(s):  
Keyword(s):  
Mead Acid

Trans isomeric octadecenoic acids are related inversely to arachidonic acid and DHA and positively related to mead acid in umbilical vessel wall lipids

Lipids ◽  
2002 ◽  
Vol 37 (10) ◽  
pp. 959-965 ◽  
Author(s):  
Tamás Decsi ◽  
Günther Boehm ◽  
H. M. Ria Tjoonk ◽  
Szilárd Molnár ◽  
D. A. Janneke Dijck-Brouwer ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Vessel Wall ◽  
Mead Acid ◽  
Umbilical Vessel ◽  
Octadecenoic Acids

scholarly journals Mead acid inhibits the growth of KPL-1 human breast cancer cells in vitro and in vivo

2014 ◽  
Vol 32 (4) ◽  
pp. 1385-1394 ◽  
Author(s):  
YUICHI KINOSHITA ◽  
KATSUHIKO YOSHIZAWA ◽  
KEI HAMAZAKI ◽  
YUKO EMOTO ◽  
TAKASHI YURI ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mead Acid

scholarly journals The Effects of Omega-3 Supplementation and Doxorubicin-Based Chemotherapy on the Murine Brain Lipidome

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 309-309
Author(s):  
Djawed Bennouna ◽  
Melissa Solano ◽  
Tonya Orchard ◽  
A Courtney DeVries ◽  
Maryam Lustberg ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Cognitive Decline ◽  
P Value ◽  
Breast Cancer Patients ◽  
Omega 3 ◽  
Chemotherapy Treatment ◽  
Resolvin D1 ◽  
Mead Acid ◽  
Funding Sources ◽  
P 16

Abstract Objectives To determine how omega-3 (n3-FA) supplementation may confer protection against lipid modifications following doxorubicin-based chemotherapy (DOX). Methods Ovariectomized C57BL/6 mice consumed a diet with 0% or 2% kcal supplemental EPA + DHA for 4 weeks, followed by two injections of either DOX (9 mg/kg) + cyclophosphamide (90 mg/kg), or vehicle. In study 1, animals were sacrificed at 4, 7, and 14 days after the last injection (n = 120) and in study 2, at 10 days after the last injection (n = 40). Whole brain from study 1 were analyzed by targeted methods (UHPLC-MS/MS), to quantify specialized pro-resolving mediators resolvin D1 (RvD1), resolvin D2 (RvD2), resolvin D3 (RvD3), resolvin D5 (RvD5), resolvin E1 (RvE1), maresin (MaR1), and protectin (PD1). In study 2, lipidomics analyses were performed on hippocampus to determine changes in the lipidome after n3-FA supplementation and chemotherapy injection. Results Study 1 results: RvD1 was present in all samples, but no significant differences in concentration were observed regardless of treatment or dietary group. RvD3, PD1 and MaR1 were detected in a subset of samples. Study 2 results: EPA + DHA (2%) supplementation favorably altered lipids associated with cognitive function (i.e., PE (P-16:0/20:5), PE (P-18:0/22:6, with adjusted p-value equal to 0.003 and 0.04 respectively), which have been previously negatively correlated with Alzheimer's and Parkinson's disease. Chemotherapy treatment increases omega-9 fatty acids (i.e., nervonic, gadoleic and mead acid) previously positively correlated with diseases of cognitive decline (e.g., Alzheimer's, Parkinson's). No chemo*n3-FA interaction was observed (p-value > 0.05). Conclusions N3-FA supplementation favorably altered lipids associated with cognitive function. DOX increased lipids associated with diseases of cognitive decline. Future investigations will determine if the same biomarkers of n-3 FA consumption and chemotherapy are observed in human breast cancer patients. Funding Sources This research was supported by a Foods for Health Discovery Themes Initiative SEEDS grant, NIH R01CA189947, NIH Award Number Grant P30 CA016058, OSU, and OSUCCC.

scholarly journals Potential Benefits of Ameliorating Metabolic and Nutritional Abnormalities in People With Profound Developmental Disabilities

2017 ◽  
Vol 10 ◽  
pp. 117863881771645
Author(s):  
Norris R Glick ◽  
Milton H Fischer
Keyword(s):  
Quality Of Life ◽  
Oxidative Stress ◽  
Amino Acids ◽  
Developmental Disabilities ◽  
Mead Acid ◽  
Other Substances ◽  
Adrenic Acid ◽  
Potential Benefits ◽  
Cell Implantation

Background: People with profound developmental disabilities have some of the most severe neurological impairments seen in society, have accelerated mortality due to huge medical challenges, and yet are often excluded from scientific studies. They actually have at least 2 layers of conditions: (1) the original disability and (2) multiple under-recognized and underexplored metabolic and nutritional imbalances involving minerals (calcium, zinc, and selenium), amino acids (taurine, tryptophan), fatty acids (linoleic acid, docosahexaenoic acid, arachidonic acid, adrenic acid, Mead acid, plasmalogens), carnitine, hormones (insulinlike growth factor 1), measures of oxidative stress, and likely other substances and systems. Summary: This review provides the first list of metabolic and nutritional abnormalities commonly found in people with profound developmental disabilities and, based on the quality of life effects of similar abnormalities in neurotypical people, indicates the potential effects of these abnormalities in this population which often cannot communicate symptoms. Key messages: We propose that improved understanding and management of these disturbed mechanisms would enhance the quality of life of people with profound developmental disabilities. Such insights may also apply to people with other conditions associated with disability, including some diseases requiring stem cell implantation and living in microgravity.

Studies on the metabolism of [1-14C]5.8.11-eicosatrienoic (Mead) acid in rat hepatocytes

1995 ◽  
Vol 1259 (1) ◽  
pp. 82-88 ◽  
Author(s):  
Kjetil Retterstøl ◽  
Bent Woldseth ◽  
Bjørn O. Christophersen
Keyword(s):  
Rat Hepatocytes ◽  
Mead Acid

scholarly journals Mead acid supplementation does not rescue rats from cataract and retinal degeneration induced by N-methyl-N-nitrosourea

2015 ◽  
Vol 28 (1) ◽  
pp. 11-20 ◽  
Author(s):  
Yuko Emoto ◽  
Katsuhiko Yoshizawa ◽  
Kei Hamazaki ◽  
Yuichi Kinoshita ◽  
Michiko Yuki ◽  
...  
Keyword(s):  
Retinal Degeneration ◽  
Mead Acid ◽  
Acid Supplementation

scholarly journals Dietary effect of mead acid on DMBA‑induced breast cancer in female Sprague‑Dawley rats

2020 ◽  
Vol 1 (2) ◽  
pp. 1-1
Author(s):  
Yuichi Kinoshita ◽  
Masahiro Yoshioka ◽  
Yuko Emoto ◽  
Takashi  Yuri ◽  
Michiko Yuki ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Sprague Dawley ◽  
Mead Acid ◽  
Sprague Dawley Rats

scholarly journals Suppressive effects of mead acid supplementation on acute liver damage derived from green tea extract

2021 ◽  
Vol 30 (1) ◽  
pp. 60-72
Author(s):  
Yuichi Kinoshita ◽  
Akiko Takenouchi ◽  
Momoka Chatani ◽  
Masahiro Yoshioka ◽  
Yuko Emoto ◽  
...  
Keyword(s):  
Green Tea ◽  
Liver Damage ◽  
Green Tea Extract ◽  
Acute Liver Damage ◽  
Mead Acid ◽  
Acid Supplementation ◽  
Tea Extract

Maternal-Fetal N-6 and N-3 Polyunsaturated Fatty Acids Gradient in Plasma and Red Cell Phospholipids

2001 ◽  
Vol 71 (5) ◽  
pp. 286-292 ◽  
Author(s):  
Y. Min ◽  
K. Ghebremeskel ◽  
M. A. Crawford ◽  
J. H. Nam ◽  
A. Kim ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Physiological Response ◽  
Venous Blood ◽  
Fatty Acid Distribution ◽  
Maternal Blood ◽  
Fat Intake ◽  
Red Cell ◽  
High Fat ◽  
Mead Acid ◽  
Korean Mothers

Fatty acid distribution was investigated in ethnically and economically homogenous Korean mothers (n = 40) and neonates. Venous blood, maternal before delivery and cord, was obtained. Choline (CPG) and ethanolamine (EPG) phosphoglycerides and sphingomyelin (SM) were assayed. Mean arachidonic acid (AA) level was higher in plasma CPG and SM (p < 0.0001), and red cell CPG (p < 0.0001), EPG (p < 0.0001) and SM (p = 0.005) of the neonates. Similarly, the neonates had higher proportions of docosahexaenoic acid (DHA) in plasma CPG (p < 0.0001) and red cell CPG (p = 0.001) and EPG (p = 0.036). In contrast, linoleic and alpha-linolenic acids were significantly higher in maternal blood. Mead acid was elevated in plasma CPG (p < 0.0001) and red cell CPG and EPG (p < 0.0001) of the neonates. Consistent with data from high-fat-intake populations, our subjects, whose traditional diet is low in fat, exhibited maternal-fetal gradient in AA and DHA in plasma and red cell phospholipids. This may be due to an imbalance between supply and maternal and fetal requirements, and/or a physiological response to pregnancy. Prenatal nutritional constraint is associated with impaired development and a risk of chronic diseases in adults. AA and DHA are vital nutrients. Hence, there is a need to investigate whether the discrepancy between maternal and neonatal AA and DHA is a manifestation of nutritional insufficiency.

scholarly journals Plasma and Red Blood Cell PUFAs in Home Parenteral Nutrition Paediatric Patients—Effects of Lipid Emulsions

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3748
Author(s):  
Antonella Lezo ◽  
Valentina D’Onofrio ◽  
Maria Paola Puccinelli ◽  
Teresa Capriati ◽  
Antonella De Francesco ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Blood Cell ◽  
Parenteral Nutrition ◽  
Fish Oil ◽  
Red Blood Cell ◽  
Healthy Children ◽  
Lipid Emulsions ◽  
Mead Acid ◽  
Paediatric Patients

Background: Mixed lipid emulsions (LE) containing fish oil present several advantages compared to the sole soybean oil LE, but little is known about the safety of essential fatty acids (EFA) profile in paediatric patients on long-term Parenteral Nutrition (PN). Aim of the study: to assess glycerophosfolipid polyunsaturated fatty acids (PUFA) levels on plasma and red blood cell (RBC) membrane of children on long term PN with composite LE containing fish oil (SMOF), and to compare it with a group receiving olive oil LE (Clinoleic®) and to the reference range for age, previously determined on a group of healthy children. Results: A total of 38 patients were enrolled, median age 5.56 (0.9–21.86) years, 15 receiving Clinoleic®, 23 receiving SMOF. Patients on SMOF showed significantly higher levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), lower levels of arachidonic acid (ARA) and Mead acid (MEAD)/ARA ratio in plasma and RBC compared with patients on Clinoleic® and with healthy children. Triene:tetraene (T:T) ratio of both groups of patients did not differ from that of healthy children-median plasma (MEAD/ARA: 0.01, interquartile rage (IQR) 0.01, p = 0.61 and 0.02, IQR 0.02, p = 0.6 in SMOF and Clinoleic® patients, respectively), and was considerably lower than Holman index (>0.21). SMOF patients showed no statistically significant differences in growth parameters compared with Clinoleic® patients. Patients of both groups showed stiffness class F0-F1 of liver stiffness measure (LSM) 5.6 (IQR 0.85) in SMOF patients and 5.3 (IQR 0.90) in Clinoleic® patients, p = 0.58), indicating absence of liver fibrosis. Conclusions: Fatty acids, measured as concentrations (mg/L), revealed specific PUFA profile of PN patients and could be an accurate method to evaluate nutritional status and eventually to detect essential fatty acid deficiency (EFAD). SMOF patients showed significantly higher EPA, DHA and lower ARA concentrations compared to Clinoleic® patients. Both LEs showed similar hepatic evolution and growth.

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