scholarly journals Dietary effect of mead acid on DMBA‑induced breast cancer in female Sprague‑Dawley rats

2020 ◽  
Vol 1 (2) ◽  
pp. 1-1
Author(s):  
Yuichi Kinoshita ◽  
Masahiro Yoshioka ◽  
Yuko Emoto ◽  
Takashi  Yuri ◽  
Michiko Yuki ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Sprague Dawley ◽  
Mead Acid ◽  
Sprague Dawley Rats

scholarly journals Exploration of anti-breast cancer effects of Terminalia chebula extract on DMBA-induced mammary carcinoma in Sprague Dawley rats

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Deena Priscilla Henry ◽  
Jasmine Ranjan ◽  
Rajesh Kumar Murugan ◽  
Annapoorani Sivanantham ◽  
Manikandan Alagumuthu
Keyword(s):  
Breast Cancer ◽  
Plant Extract ◽  
Mammary Carcinoma ◽  
Future Perspective ◽  
Terminalia Chebula ◽  
Sprague Dawley ◽  
Analytical Technique ◽  
Isolation And Characterization ◽  
Sprague Dawley Rats ◽  
Mcf 7

Abstract Background Plant extracts are effectively acting as the natural medicinal cocktail, non-side effective, efficacious, and freely available. The present study aimed to unveil the pharmacological and medicinal effects of Terminalia chebula plant extract in 7,12-dimethylbenzanthracene (DMBA)-induced mammary carcinoma in Sprague Dawley rats. The plant extract obtained was subjected to in vivo antioxidant and anticancer studies in various concentrations after an analytical technique such as FTIR, GCMS, and HPLC-based chemo-profiling in Sprague Dawley rats. Results Apart from the antiproliferative effect on breast cancer cell line (MCF-7) and normal breast epithelial cells (MCF-10a), we have measured the changes in body weight, along with other tumor parameters such as tumor volume, tumor incidence, tumor weight, tumor burden, serum biochemical parameters, and histopathological findings of breast tissue. As the oxidative stress further enhances the development of cancer, the antioxidant property of the plant extract demonstrates its use against cancer treatment. One hundred fifty milligrams per milliliter (IC50 250 μg/mL) concentration of the ethanolic extract was vital for the proliferation of MCF-7 cell lines (Fig. 7a). Meanwhile, 300 μg/mL (IC50 150 μg/mL) was an effective dose to attain a maximum HDAC inhibition of 78%. Also, the normal liver and kidney functioning revealed the non-toxicity nature of the plant. Conclusion Terminalia chebula could be one of the effective naturally obtained anti-breast cancer medications. Isolation and characterization of individual bioactive compounds of T. chebula would be the future perspective.

Preventive effect of berberine against DMBA-induced breast cancer in female Sprague Dawley rats

2017 ◽  
Vol 92 ◽  
pp. 207-214 ◽  
Author(s):  
Kalyani Chowdary Karnam ◽  
Maheswara Ellutla ◽  
Lakshmi Narendra Bodduluru ◽  
Eshvendar Reddy Kasala ◽  
Shravan Kumar Uppulapu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Preventive Effect ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Antiproliferative and Apoptotic Effects of Shemamruthaa, a Herbal Preparation, in 7,12-Dimethylbenz(a)Anthracene-Induced Breast Cancer Rats

2015 ◽  
Vol 20 (4) ◽  
pp. 259-268 ◽  
Author(s):  
Ayyakkannu Purushothaman ◽  
Elumalai Nandhakumar ◽  
Palanivelu Shanthi ◽  
Thiruvaiyaru Panchanatham Sachidanandam
Keyword(s):  
Breast Cancer ◽  
Mammary Carcinoma ◽  
Nuclear Antigen ◽  
Herbal Preparation ◽  
Sprague Dawley ◽  
Protein Levels ◽  
Anticancer Effects ◽  
Sprague Dawley Rats ◽  
Apoptotic Effects ◽  
Proliferating Cell

A herbal preparation, Shemamruthaa (SM), was formulated to investigate the molecular mechanism by which it exhibits anticancer effects in mammary carcinoma bearing rats. Female Sprague-Dawley rats were used for the study, and mammary carcinoma was induced by administration of 7,12-dimethylbenz( a)anthracene, intragastrically. After 3 months of induction period, the rats were treated with SM (400 mg/kg body weight) for 14 days. Our study shows that SM-treated mammary carcinoma rats showed regression in tumor volume with concomitant increase in p53, Bax, caspase-3, and caspase-9 mRNA and protein levels compared with mammary carcinoma–induced rats. Proliferating cell nuclear antigen and anti-apoptotic Bcl-2 were markedly increased in mammary carcinoma–induced rats, whereas the SM treatment significantly decreased the expression of these proteins. The expression pattern of apoptotic signaling molecules analyzed in the present study signifies the therapeutic efficacy of SM against breast cancer.

Effects of Dehydroepiandrosterone on MNU-Induced Breast Cancer in Sprague-Dawley Rats

2006 ◽  
Vol 774 (1) ◽  
pp. 340-341 ◽  
Author(s):  
R. A. LUBET ◽  
D. M. McCORMICK ◽  
G. M. GORDON ◽  
C. GRUBBS ◽  
X-D LEI ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Mammary Tumors Growing in the Absence of Growth Hormone Are More Sensitive to Doxorubicin Than Wild-Type Tumors

Endocrinology ◽  
2021 ◽  
Vol 162 (4) ◽  
Author(s):  
Daniel D Lantvit ◽  
Christopher J Unterberger ◽  
Michelle Lazar ◽  
Paige D Arneson ◽  
Colin A Longhurst ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Hormone ◽  
Endogenous Growth ◽  
Mammary Tumors ◽  
Wild Type ◽  
Sprague Dawley ◽  
Doxorubicin Treatment ◽  
Sprague Dawley Rats ◽  
Almost All ◽  
Treat Breast Cancer

Abstract Previously, we reported that N-methyl-N-nitrosourea (MNU)-induced mammary tumors could be established in mutant spontaneous dwarf rats (SDRs), which lack endogenous growth hormone (GH) by supplementing with exogenous GH, and almost all such tumors regressed upon GH withdrawal. When the highly inbred SDR line was outcrossed to wild-type (WT) Sprague-Dawley rats, MNU-induced mammary tumors could still be established in resulting outbred SDRs by supplementing with exogenous GH. However, unlike tumors in inbred SDRs, 65% of mammary tumors established in outbred SDRs continued growth after GH withdrawal. We further tested whether these tumors were more sensitive to doxorubicin than their WT counterparts. To accomplish this, MNU-induced mammary tumors were established in WT rats and in SDRs supplemented with exogenous GH. Once mammary tumors reached 1 cm3 in size, exogenous GH was withdrawn from SDRs, and the subset that harbored tumors that continued or resumed growth in the absence of GH were selected for doxorubicin treatment. Doxorubicin was then administered in 6 injections over 2 weeks at 2.5 mg/kg or 1.25 mg/kg for both the WT and SDR groups. The SDR mammary tumors that had been growing in the absence of GH regressed at both doxorubicin doses while WT tumors continued to grow robustly. The regression of SDR mammary tumors treated with 1.25 mg/kg doxorubicin was accompanied by reduced proliferation and dramatically higher apoptosis relative to the WT mammary tumors treated with 1.25 mg/kg doxorubicin. These data suggest that downregulating GH signaling may decrease the doxorubicin dose necessary to effectively treat breast cancer.

Mammary tumors in Sprague Dawley rats induced by N-ethyl-N-nitrosourea for evaluating terahertz imaging of breast cancer

2021 ◽  
Vol 8 (02) ◽  
Author(s):  
Nagma Vohra ◽  
Tanny Chavez ◽  
Joel R. Troncoso ◽  
Narasimhan Rajaram ◽  
Jingxian Wu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mammary Tumors ◽  
Terahertz Imaging ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Free radical scavenging and antioxidant activity of D-pinitol against 7, 12 dimethylbenz (a) anthracene induced breast cancer in sprague dawley rats

2014 ◽  
Vol 4 (5) ◽  
pp. 384-390 ◽  
Author(s):  
Thamaraiselvan Rengarajan ◽  
Peramaiyan Rajendran ◽  
Natarajan Nandakumar ◽  
Maruthaiveeran Periyasamy Balasubramanian ◽  
Ikuo Nishigaki
Keyword(s):  
Breast Cancer ◽  
Antioxidant Activity ◽  
Free Radical ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Sprague Dawley ◽  
Sprague Dawley Rats
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