scholarly journals Antibiotic Lock Therapy

2020 ◽  
Author(s):  
Keyword(s):  
Lock Therapy ◽  
Antibiotic Lock

scholarly journals β-Lactam antibiotics and vancomycin inhibit the growth of planktonic and biofilm Candida spp.: An additional benefit of antibiotic-lock therapy?

2015 ◽  
Vol 45 (4) ◽  
pp. 420-423 ◽  
Author(s):  
José J.C. Sidrim ◽  
Carlos E.C. Teixeira ◽  
Rossana A. Cordeiro ◽  
Raimunda S.N. Brilhante ◽  
Débora S.C.M. Castelo-Branco ◽  
...  
Keyword(s):  
Additional Benefit ◽  
Candida Spp ◽  
Lock Therapy ◽  
Antibiotic Lock

Successful prevention of tunneled central catheter infection by antibiotic lock therapy using cefazolin and gentamicin

2012 ◽  
Vol 45 (5) ◽  
pp. 1405-1413 ◽  
Author(s):  
T. N. V. Silva ◽  
M. L. Mendes ◽  
J. M. G. Abrão ◽  
J. T. Caramori ◽  
D. Ponce
Keyword(s):  
Central Catheter ◽  
Catheter Infection ◽  
Lock Therapy ◽  
Antibiotic Lock ◽  
Successful Prevention

Antibiotic-lock therapy in central venous catheter colonization in patients with intestinal failure

2007 ◽  
Vol 54 (4) ◽  
pp. 415-416
Author(s):  
A. Diamanti ◽  
M.S. Basso ◽  
M. Castro ◽  
A. Calce ◽  
M. Gambarara
Keyword(s):  
Central Venous Catheter ◽  
Intestinal Failure ◽  
Venous Catheter ◽  
Catheter Colonization ◽  
Central Venous ◽  
Lock Therapy ◽  
Antibiotic Lock

scholarly journals High-Dose Daptomycin Is Effective as an Antibiotic Lock Therapy in a Rabbit Model of Staphylococcus epidermidis Catheter-Related Infection

2017 ◽  
Vol 62 (2) ◽  
Author(s):  
Jana Basas ◽  
Marta Palau ◽  
Carlos Ratia ◽  
José L. del Pozo ◽  
María Teresa Martín-Gómez ◽  
...  
Keyword(s):  
Staphylococcus Epidermidis ◽  
Rabbit Model ◽  
Bloodstream Infections ◽  
High Dose ◽  
Coagulase Negative Staphylococci ◽  
Poor Patient ◽  
Lock Therapy ◽  
Antibiotic Lock ◽  
High Treatment

ABSTRACT Long-term catheter-related bloodstream infections (CRBSIs) involving coagulase-negative staphylococci are associated with poor patient outcomes, increased hospitalization, and high treatment costs. The use of vancomycin lock therapy has been an important step forward in treatment of these biofilms, although failures occur in 20% of patients. In this study, we report that a high dose of daptomycin lock therapy may offer a therapeutic advantage for these CRBSIs in just 24 h of treatment.

Role of Antibiotic Lock Therapy for the Treatment of Catheter-Related Bloodstream Infections

2009 ◽  
Vol 32 (9) ◽  
pp. 678-688 ◽  
Author(s):  
Jose L Del Pozo
Keyword(s):  
Antimicrobial Agents ◽  
Therapeutic Option ◽  
Bloodstream Infections ◽  
Resistance Pattern ◽  
Published Data ◽  
Sufficient Power ◽  
Lock Therapy ◽  
Antibiotic Lock ◽  
The Stability ◽  
Systemic Antibiotics

Catheter-related bloodstream infections are often difficult to treat because they are caused by organisms that embed themselves in a bio film layer on the catheter surface, resulting in an increased resistance to antimicrobial agents. Systemic antibiotics are usually administered but, although generally effective in eliminating circulating bacteria, they frequently fail to sterilize the line, leaving the patient at a continuing risk of complications or recurrence. A successful approach to managing these infections requires making an appropriate decision regarding whether the catheter should be removed or retained using antibiotic lock therapy; and choosing the type and duration of antimicrobial therapy based on the type of organism and its resistance pattern. Studies that have evaluated antibiotic lock therapy have varied in the types of antibiotics and concentrations used, the addition of heparin to the solutions, and dwell times in the catheter lumen. Guidelines from the Infectious Diseases Society of America include use of antibiotic lock therapy as a therapeutic option for intraluminal infections when the device is not removed and, although not routine, as prophylaxis for catheter-related infection in select patient populations. However, there are no published guidelines on the concentration of heparin or antibiotics that should be used, and minimal published data on the stability of heparin combinations with antibiotics. It is to be hoped that antibiotic locks will be subject to randomized controlled trials of sufficient power to confirm or refute their use.

scholarly journals 2117. Catheter-related Bacteremia in Hemodialysis Patients on Antibiotic Lock Therapy: Are Antibiotic Locks Ineffective?

2018 ◽  
Vol 5 (suppl_1) ◽  
pp. S621-S621
Author(s):  
Amar Krishna ◽  
Bhagyashri Navalkele ◽  
Suganya Chandramohan ◽  
Teena Chopra
Keyword(s):  
Hemodialysis Patients ◽  
Lock Therapy ◽  
Antibiotic Lock

1624 Antibiotic lock therapy with vancomycin and daptomycin for cathether salvage in long-term catheter

2015 ◽  
Vol 51 ◽  
pp. S246-S247
Author(s):  
B. López Garcýa ◽  
S. Ortonobes Roig ◽  
S. Servitja ◽  
S. Grau ◽  
I. Tusquets ◽  
...  
Keyword(s):  
Lock Therapy ◽  
Antibiotic Lock

Daptomycin is effective as antibiotic-lock therapy in a model of Staphylococcus aureus catheter-related infection

2014 ◽  
Vol 68 (6) ◽  
pp. 548-552 ◽  
Author(s):  
Yolanda Meije ◽  
Benito Almirante ◽  
José Luis Del Pozo ◽  
María Teresa Martín ◽  
Nuria Fernández-Hidalgo ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Catheter Related Infection ◽  
Lock Therapy ◽  
Antibiotic Lock
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