scholarly journals Pepsinogen A Measurement

2020 ◽  
Author(s):  
Keyword(s):  
Pepsinogen A

scholarly journals Diagnostic value of serum pepsinogen C in patients with raised serum concentrations of pepsinogen A.

Gut ◽  
1993 ◽  
Vol 34 (10) ◽  
pp. 1315-1318 ◽  
Author(s):  
I Biemond ◽  
J Kreuning ◽  
J B Jansen ◽  
C B Lamers
Keyword(s):  
Diagnostic Value ◽  
Serum Pepsinogen ◽  
Serum Concentrations ◽  
Pepsinogen C ◽  
Pepsinogen A

Transcription Regulation of Human and Porcine Pepsinogen A

1995 ◽  
pp. 67-75 ◽  
Author(s):  
G. Pals ◽  
P. H. S. Meijerink ◽  
J. Defize ◽  
J. P. Bebelman ◽  
M. Strunk ◽  
...  
Keyword(s):  
Transcription Regulation ◽  
Pepsinogen A

The Effect of Acute and Chronic Protein Loading on Urinary Pepsinogen A Excretion

Nephron ◽  
1991 ◽  
Vol 59 (2) ◽  
pp. 239-243 ◽  
Author(s):  
M.A.G.J. ten Dam ◽  
G.J. van Kamp ◽  
A. Kok ◽  
S.G.M. Meuwissen ◽  
A.J.M. Donker ◽  
...  
Keyword(s):  
Protein Loading ◽  
Pepsinogen A

Stimulation of gastric proteases in the neonatal pig by a rise in adrenocortical secretion at parturition

1995 ◽  
Vol 7 (5) ◽  
pp. 1293 ◽  
Author(s):  
PT Sangild
Keyword(s):  
Adrenocorticotropic Hormone ◽  
Perinatal Period ◽  
Postnatal Period ◽  
Late Gestation ◽  
Cortisol Secretion ◽  
Adrenocortical Activity ◽  
Pepsinogen A ◽  
Newborn Pigs ◽  
Neonatal Pig ◽  
Stimulation Of

In many species adrenocortical activity and glucocorticoid secretion increase in late gestation and reach a peak at birth. In this study, we investigated the hypothesis that glucocorticoids stimulate the synthesis of gastric protease zymogens in the perinatal period of pigs. Pigs were delivered by Caesarean section 3-4 days prior to term (to circumvent the natural cortisol surge) and treated daily with either saline (n = 11), metyrapone (an inhibitor of cortisol synthesis, n = 12), adrenocorticotropic hormone (ACTH, n = 14) or cortisol-acetate (n = 6). The pigs were killed at 3 or 6-7 days of age and concentrations of protease zymogens in gastric mucosal extracts determined by electroimmunoassay. Zymogen contents were also determined in control (untreated) pigs from one week before birth to four weeks after birth. In control pigs, concentration of prochymosin increased rapidly before term, peaked at birth, and decreased in the postnatal period; concentrations of pepsinogen A, pepsinogen B and progastricsin were low in newborn pigs and increased in the weeks after birth. Caesarean-delivered pigs injected with saline had lower concentrations of prochymosin and pepsinogen A at 6-7 days than vaginally delivered pigs of the same postnatal age. The concentrations of these zymogens were further reduced after metyrapone treatment (depressed cortisol secretion) but were increased after treatment with ACTH (stimulated cortisol secretion) or cortisol-acetate (exogenous glucocorticoid). No consistent effects were observed for the two minor gastric protease zymogens in the pig, pepsinogen B and progastricsin. The results suggest that the normal pre-partum surge in circulating cortisol stimulates the development of the major gastric protease zymogens in the pig, prochymosin and pepsinogen A.

scholarly journals Gastric chief cell-specific transcription of the pepsinogen A gene

1993 ◽  
Vol 213 (3) ◽  
pp. 1283-1296 ◽  
Author(s):  
Peter H. S. MEIJERINK ◽  
Jan-Paul BEBELMAN ◽  
Anja M. OLDENBURG ◽  
Jacques DEFIZE ◽  
Rudi J. PLANTA ◽  
...  
Keyword(s):  
Chief Cell ◽  
Pepsinogen A

Tubular reabsorption of pepsinogen isozymogens in man studied by the inhibition of tubular protein reabsorption with dibasic amino acids

1991 ◽  
Vol 80 (2) ◽  
pp. 161-166 ◽  
Author(s):  
M. A. G. J. ten Dam ◽  
A. Zwiers ◽  
J. B. A. Crusius ◽  
G. Pals ◽  
G. J. van Kamp ◽  
...  
Keyword(s):  
Body Weight ◽  
Specific Binding ◽  
Tubular Reabsorption ◽  
Radioisotope Method ◽  
Pepsinogen C ◽  
Pepsinogen A ◽  
Fractional Clearance ◽  
Arginine Hydrochloride ◽  
Identical Amino Acid Sequence ◽  
Protein Reabsorption

1. The fractional clearances of pepsinogen A (PGA), pepsinogen C (PGC) and the main PGA isozymogens, i.e. PGA-3, PGA-4 and PGA-5, were measured in 13 healthy male volunteers before and during blockade of tubular protein reabsorption by intravenous infusion of either l-arginine hydrochloride (n = 8; 0.5 g h−1 kg−1 body weight) or an equimolar amount of l-lysine hydrochloride (n = 5; 0.44 g h−1 kg−1 body weight). Glomerular filtration rate was measured by a radioisotope method. 2. The fractional baseline clearance of PGC (1 ± 1%) was lower than that of PGA (20 ± 10%). In addition, the fractional clearance of the PGA isozymogens appeared to be different: the fractional clearance of PGA-5 (7 ± 3%) was lower than that of PGA-4 (18 ± 9%), and the fractional clearance of PGA-4 was lower than that of PGA-3 (30 ± 10%). These differences in fractional clearance between PGA isozymogens decreased during infusion of both arginine and lysine. 3. Pepsinogens are freely filtered proteins. It can therefore be concluded that the differences in fractional clearance between PGA isozymogens imply differences in tubular reabsorption. This is remarkable as PGA isozymogens are proteins with an almost identical amino acid sequence and electric charge. The disappearance of the differences in tubular reabsorption during arginine and lysine infusion suggests that PGA isozymogens differ in affinity for negatively charged binding sites in the tubular cell membrane. In order to explain the low fractional clearance of PGC compared with that of PGA and the less marked effect of arginine or lysine infusion on the fractional clearance of PGC, an additional PGC-specific binding site has to be postulated.

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