Gemistocytic Astrocytoma, IDH-Mutant

Cerebral Gemistocytic Astrocytoma in a Cat

Japanese Journal of Veterinary Anesthesia & Surgery ◽

10.2327/jvas.41.23 ◽

2010 ◽

Vol 41 (1) ◽

pp. 23-27

Author(s):

Takeshi AIKAWA ◽

Taishi TAKAHASHI ◽

Hiroshi FUJITA ◽

Mitsuhiro SHIBATA ◽

Takeo MINAMI

Keyword(s):

Gemistocytic Astrocytoma

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Congenital gemistocytic astrocytoma in a fetus

Child s Nervous System ◽

10.1007/s00381-004-1109-x ◽

2005 ◽

Vol 22 (2) ◽

pp. 168-171 ◽

Cited By ~ 8

Author(s):

Michimasa Nozaki ◽

Akiko Ohnishi ◽

Takamitsu Fujimaki ◽

Kazuo Nagashima ◽

Kazutoshi Cho ◽

...

Keyword(s):

Gemistocytic Astrocytoma

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High-Grade Residual Tumor: Morphofunctional MR Follow-Up in Gemistocytic Astrocytoma

Imaging Gliomas After Treatment ◽

10.1007/978-3-030-31210-7_26 ◽

2019 ◽

pp. 135-138

Author(s):

Francesco Fabbiano ◽

Alessandro Stecco ◽

Sara Zizzari ◽

Gerardo Di Nardo ◽

Anthony Azubuike Obaze ◽

...

Keyword(s):

Residual Tumor ◽

High Grade ◽

Gemistocytic Astrocytoma

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Low-Grade Gemistocytic Morphology in H3 G34R-Mutant Gliomas and Concurrent K27M Mutation: Clinicopathologic Findings

Journal of Neuropathology & Experimental Neurology ◽

10.1093/jnen/nlaa101 ◽

2020 ◽

Vol 79 (10) ◽

pp. 1038-1043

Author(s):

Meaghan Morris ◽

Meghan Driscoll ◽

John W Henson ◽

Charles Cobbs ◽

LiQun Jiang ◽

...

Keyword(s):

Histone H3 ◽

Low Grade ◽

High Grade ◽

K27m Mutation ◽

Gemistocytic Astrocytoma ◽

First Case ◽

Clinicopathologic Findings ◽

Tumor Phenotype ◽

High Grade Gliomas ◽

H3 K27m Mutations

Abstract Mutations in histone H3 are key molecular drivers of pediatric and young adult high-grade gliomas. Histone H3 G34R mutations occur in hemispheric high-grade gliomas and H3 K27M mutations occur in aggressive, though histologically diverse, midline gliomas. Here, we report 2 rare cases of histologically low-grade gliomas with gemistocytic morphology and sequencing-confirmed histone H3 G34R mutations. One case is a histologically low-grade gemistocytic astrocytoma with a G34R-mutation in H3F3A. The second case is a histologically low-grade gemistocytic astrocytoma with co-occurring K27M and G34R mutations in HIST1H3B. Review of prior histone H3-mutant gliomas sequenced at our institution shows a divergent clinical and immunohistochemical pattern in the 2 cases. The first case is similar to prior histone H3 G34R-mutant tumors, while the second case most closely resembles prior histone H3 K27M-mutant gliomas. These represent novel cases of sequencing-confirmed histone H3 G34R-mutant gliomas with low-grade histology and add to the known rare cases of G34R-mutant tumors with gemistocytic morphology. Although K27M and G34R mutations are thought to be mutually exclusive, we document combined K27M and G34R mutations in HIST1H3B and present evidence suggesting the K27M-mutation drove tumor phenotype in this dual mutant glioma.

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A gemistocytic astrocytoma demonstrated high intensity on MR images

Neuroradiology ◽

10.1007/bf00588571 ◽

1990 ◽

Vol 32 (2) ◽

pp. 166-167 ◽

Cited By ~ 15

Author(s):

K. Abe ◽

H. Hasegawa ◽

Y. Kobayashi ◽

H. Fujimura ◽

S. Yorifuji ◽

...

Keyword(s):

High Intensity ◽

Mr Images ◽

Gemistocytic Astrocytoma

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Migration of cerebral sparganosis to the ipsilateral cerebellar hemisphere

Acta Parasitologica ◽

10.2478/s11686-009-0035-1 ◽

2009 ◽

Vol 54 (3) ◽

Cited By ~ 3

Author(s):

Ki Eom ◽

Tae Kim

Keyword(s):

Frontal Lobe ◽

Serological Test ◽

Cerebellar Hemisphere ◽

Subtotal Resection ◽

Histopathological Diagnosis ◽

Left Frontal Lobe ◽

Gemistocytic Astrocytoma ◽

Post Surgery ◽

Live Worm ◽

Cerebral Sparganosis

AbstractWe report the case of a 52-year-old man in whom multiple conglomerated ring-enhanced lesions in the left frontal lobe were revealed on magnetic resonance imaging (MRI); further, he presented with headache. Subtotal resection of the mass was performed and the histopathological diagnosis of gemistocytic astrocytoma was made. He received postoperative radiotherapy of remnant mass. Six months post-surgery, new multiple lesions were developed on the left cerebellum and the lesion yielded radiological findings that were quite similar to those of the lesion previously observed in the left frontal lobe. Total resection was performed with the aid of neuronavigation and a live yellow 10-cm-long worm with an active scolex was found. A pathologist identified the worm as a sparganum of Spirometra mansoni. This suggests that the live worm may have moved to the ipsilateral cerebellum due to the stimulus from the surgery and radiation on the frontal lobe. Although this case presented characteristic MRI findings of sparganosis, we did not conduct a serological test; therefore, we misdiagnosed sparganosis as gemistocytic astrocytoma. To the best of our knowledge, this is the first report of the ipsilateral transtentorial migration of cerebral sparganosis.

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