Hematopoietic and Lymphoid System Disorder

The etiology of Parkinson’s disease (PD), a progressive nervous system disorder that affects movement, is still unknown; both genetic and environmental factor are believed to be involved in onset of the disease and its development. Herpes simplex virus type 1 (HSV-1), in particular, is suspected to have a role in PD. Paired Immunoglobulin-like type 2 receptor alpha (PILRA) is an inhibitory receptor that down-regulates inflammation and is expressed on innate immune cells. The PILRA rs1859788 polymorphism is protective against Alzheimer’s disease, even in relation with HSV-1 antibody titers, but no data are available in PD. We analyzed HSV-1 antibody titers and PILRA rs1859788 in PD (n = 51) and age-and sex-matched healthy controls (HC; n = 73). Results showed that HSV-1, but not cytomegalovirus (CMV) or human herpes virus type 6 (HHV-6) antibody titers were significantly higher in PD compared to HC (p = 0.045). The rs1859788 polymorphism was not differentially distributed between PD and HC, but the minor allele A was more frequently carried by PD (68%) compared to HC (50%) (p = 0.06). Notably, the rs1859788 minor allele A was statically more frequent in male PD (65%) compared to male HC (37%) (p = 0.036). Finally, no relation was found between HSV-1 antibody titers and PILRA genotype. Results herein suggest an involvement of HSV-1 in PD and indicate a possible interaction between PILRA gene polymorphisms and this neuropathology.

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The Physiological Role of the Lymphoid System

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)62935-7 ◽

1970 ◽

Vol 245 (15) ◽

pp. 3906-3910

Author(s):

Asit K. Lahiri ◽

William M. Mitchell ◽

Victor A. Najjar

Keyword(s):

Physiological Role ◽

Lymphoid System

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Redistribution of HIV outside the lymphoid system with onset of AIDS

The Lancet ◽

10.1016/s0140-6736(94)91222-x ◽

1994 ◽

Vol 343 (8894) ◽

pp. 382-385 ◽

Cited By ~ 65

Author(s):

Y.K Donaldson ◽

P Simmonds ◽

A Busuttil ◽

J.E Bell ◽

J.W Ironside ◽

...

Keyword(s):

Lymphoid System

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Paroxysmal localized Hyperhidrosis, a case-report: When excessive sweating occurs in combination with severe headaches

Cephalalgia ◽

10.1177/03331024211006843 ◽

2021 ◽

pp. 033310242110068

Author(s):

Marleen H van Coevorden ◽

Mariëtte WCJ Schoofs ◽

Jeroen Venhovens

Keyword(s):

Nervous System ◽

Case Report ◽

Autonomic Nervous System ◽

Diagnostic Testing ◽

Abdominal Ultrasound ◽

Severe Headache ◽

Excessive Sweating ◽

Autonomic Nervous ◽

Underlying Disorder ◽

System Disorder

Background Paroxysmal localized hyperhidrosis is a rare disorder of the central autonomic nervous system. No association between paroxysmal hyperhidrosis and severe headache has been previously described in literature. Case description: A 65-year-old woman with idiopathic paroxysmal localized hyperhidrosis combined with severe holocranial headache attacks is described in this case report. Extensive diagnostic testing by means of laboratory examinations, 24-hour urinalyses, chest X-ray, abdominal ultrasound and computed tomography scans, and brain and spinal cord magnetic resonance imaging could not identify an underlying disorder. A diagnosis of idiopathic paroxysmal localized hyperhidrosis was made, and the patient was successfully treated with clonidine 0.075 mg three times a day, without any side effects. Conclusion Paroxysmal localized hyperhidrosis is a rare central autonomic nervous system disorder that can occur in combination with severe headache. Both the headache and paroxysmal hyperhidrosis complaints were treated effectively with clonidine in the patient described in this case-report.

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