Nervous System Disorder

2020 ◽  
Author(s):  
Keyword(s):  
Nervous System ◽  
Nervous System Disorder ◽  
System Disorder

scholarly journals Autonomic Nervous System Disorder Due to Exposure RF Jamming

2020 ◽  
Vol 18 (2) ◽  
pp. 124-132
Author(s):  
Ibrahim T Ibrahim ◽  
◽  
Suad M Al-Deen ◽  
Ajial S Hassan
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
Nervous System Disorder ◽  
Autonomic Nervous ◽  
System Disorder

CLINICAL AND ELECTROPHYSIOLOGICAL CHARACTERISTICS OF 103 PATIENTS WITH SENSORY NEURONOPATHY

2015 ◽  
Vol 86 (11) ◽  
pp. e4.51-e4
Author(s):  
Timothy Lavin ◽  
Sarah Al-Bachari ◽  
David Yunus Gosal
Keyword(s):  
Nervous System ◽  
Dorsal Root ◽  
Neuroendocrine Tumours ◽  
Age Of Onset ◽  
Unknown Primary ◽  
Sensory Disturbance ◽  
Nervous System Disorder ◽  
Immunomodulatory Treatment ◽  
Sensory Neuronopathy ◽  
System Disorder

Sensory Neuronopathy (SN) represents a distinct peripheral nervous system disorder associated with degeneration of the Dorsal Root Ganglia. We present our retrospective review of 103 patients with an electro-clinical diagnosis of SN.Average age of onset was 54 yr. Aetiologies included Sjogrens (21%), Probable Inflammatory (16%), Idiopathic (29%), Inherited (20%), Toxic (5%) and paraneoplastic (9%).Of those with inherited SN (n=21); CANVAS syndrome 2/21, mitochrondrial cytopathy 9/21 with 4 confirmed POLG1 mutations, 3/21 presumed HSANIIb, Frederich's Ataxia 1/21 and 6/21 unidentified phenotypes.Clinically, acquired causes commonly presented with pain (62%), asymmetrical/non-length dependent sensory disturbance (91%) as compared to the inherited group who are more likely to present with gait disturbance without prominent sensory symptoms (52%).Of the cohort with presumed inflammatory disease, 29 patients were immunosuppressed with 12 patients responding to a combination of steroids and Mycophenolate. IVIG was not found to be beneficial with no sustained benefit in 7 patients.Paraneoplastic causes (n=9) included Breast (n=2), Neuroendocrine tumours (n=2), Carcinoid (n=2), Bowel (n=1), SCLC (n=1) and unknown primary (n=1) with only 4 Hu positiveConclusionsSensory neuronopathy is clinically and aetiologically pleomorphic. In cases with a suspected inflammatory cause it is worthwhile considering a trial of immunomodulatory treatment.

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