Cold Sore

2020 ◽  
Author(s):  
Keyword(s):  
Cold Sore

scholarly journals High-Dose, Short-Duration, Early Valacyclovir Therapy for Episodic Treatment of Cold Sores: Results of Two Randomized, Placebo-Controlled, Multicenter Studies

2003 ◽  
Vol 47 (3) ◽  
pp. 1072-1080 ◽  
Author(s):  
Spotswood L. Spruance ◽  
Terry M. Jones ◽  
Mark M. Blatter ◽  
Mauricio Vargas-Cortes ◽  
Judy Barber ◽  
...  
Keyword(s):  
Day Treatment ◽  
High Dose ◽  
Herpes Labialis ◽  
Lesion Development ◽  
Multicenter Studies ◽  
Double Blind ◽  
Cold Sore ◽  
Treatment Groups ◽  
The Mean ◽  
Cold Sores

ABSTRACT Oral valacyclovir is better absorbed than oral acyclovir, increasing acyclovir bioavailability three- to fivefold. This provides the opportunity to explore whether high systemic acyclovir concentrations are effective in the treatment of cold sores (herpes labialis). Two randomized, double-blind, placebo-controlled studies were conducted. Subjects were provided with 2 g of valacyclovir twice daily for 1 day (1-day treatment), 2 g of valacyclovir twice daily for 1 day and then 1 g of valacyclovir twice daily for 1 day (2-day treatment), or a matching placebo and instructed to initiate treatment upon the first symptoms of a cold sore. In study 1, the median duration of the episode (primary endpoint) was reduced by 1.0 day (P = 0.001) with 1-day treatment and 0.5 days (P = 0.009) with 2-day treatment compared to placebo. Similarly, the mean duration of the episode was statistically significantly reduced by 1.1 days with 1-day treatment and 0.7 days with 2-day treatment compared to placebo. The proportion of subjects in whom cold sore lesion development was prevented and/or blocked was increased by 6.4% (P = 0.096) with 1-day treatment and 8.5% (P = 0.061) with 2-day treatment compared to placebo. The time to lesion healing and time to cessation of pain and/or discomfort were statistically significantly reduced with valacyclovir compared to placebo. In study 2, results similar to those in study 1 were obtained. AEs were similar across treatment groups. These studies provide evidence supporting a simple, 1-day valacyclovir treatment regimen for cold sores that is safe and effective. The 1-day valacyclovir regimen offers patients a unique and convenient dosing alternative compared to available topical therapies.

scholarly journals Protocol for a randomised controlled trial of 90% kanuka honey versus 5% aciclovir for the treatment of herpes simplex labialis in the community setting

BMJ Open ◽  
2017 ◽  
Vol 7 (8) ◽  
pp. e017766 ◽  
Author(s):  
Alex Semprini ◽  
Joseph Singer ◽  
Nicholas Shortt ◽  
Irene Braithwaite ◽  
Richard Beasley
Keyword(s):  
New Zealand ◽  
Herpes Simplex ◽  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
Healing Time ◽  
Research Network ◽  
Cold Sore ◽  
Cold Sores ◽  
Randomised Controlled ◽  
Medical Grade

IntroductionWorldwide, about 90% of people are infected with the herpes simplex virus, 30% of whom will experience recurrent herpes simplex labialis, commonly referred to as ‘cold sores’, which can last up to 10 days. The most common treatment is aciclovir cream which reduces healing time by just half a day compared with no specific treatment. This is a protocol for a randomised controlled trial (RCT) to determine the efficacy of medical grade kanuka honey-based topical treatment (Honevo) in reducing the healing time and pain of cold sores, compared with topical aciclovir treatment (Viraban).Methods and analysisThis open-label, parallel-group, active comparator superiority RCT will compare the efficacy of medical grade kanuka honey with 5% aciclovir cream in the treatment of cold sores in the setting of a pharmacy research network of 60 sites throughout New Zealand. Adults presenting with a cold sore (N=950) will be randomised by pharmacy-based investigators. The pharmacy-based investigators will dispense the investigational product to randomised participants and both study groups apply the treatment five times daily until their skin returns to normal or for 14 days, whichever occurs first. In response to a daily SMS message, participants complete an assessment of their cold sore healing, with reference to a visual guide, and transmit it to the investigators by a smartphone eDiary in real time. The primary outcome variable is time (in days) from randomisation to return to normal skin. Secondary endpoints include total healing time stratified by stage of the lesion at onset of treatment, highest pain severity and time to pain resolution.Ethics and disseminationNew Zealand Ethics Registration 15/NTB/93. Results will be published in a peer-reviewed medical journal, presented at academic meetings and reported to participants.Trial registration numberAustralia New Zealand Clinical Trials Registry: ACTRN12615000648527, pre-results.SCOTT Registration: 15/SCOTT/14Protocol version4.0 (12 June 2017)

Cold sore therapy

2020 ◽  
Vol 151 (12) ◽  
pp. 886
Author(s):  
Gerald W. Spencer
Keyword(s):  
Cold Sore

scholarly journals Vaccines, Repurposed Drugs and Alternative Biomedicines for the Management and Prevention of COVID-19

2021 ◽  
Author(s):  
Jeyalakshmi Kandhavelu ◽  
Ramesh Veeriah ◽  
Kumar Subramanian ◽  
Priyatharsini Rajendran ◽  
Olli Yli-Harja ◽  
...  
Keyword(s):  
Disease Management ◽  
Severe Acute Respiratory Syndrome ◽  
Developmental Stage ◽  
Value Added ◽  
Modern Medicine ◽  
Clinical Validation ◽  
Cold Sore ◽  
Alternative Approach ◽  
Repurposed Drugs ◽  
Value Added Products

The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) popularly called as COVID-19, is a pandemic having affected >200 countries. Globally, quarantine measures have been implemented to slow down the spread of the virus. Yet, the available vaccines and drugs for treating COVID-19 are still in design and developmental stage, requiring clinical validation. This review is focused on the progress in the development of medicines against SARS-CoV-2. As an alternative approach, both conventional and traditional biomedicines are also reported to be in practice, to treat the SARS-CoV-2 infected patients. Considering the therapeutic values of the folk medicines, this review focuses on the usage of high value added products from plants, against COVID-19 in managing the symptoms like fever, cough, cold, sore throat, respiratory disorders and kidney dysfunctions enlisting a few used since time immemorial. It is ardently hoped that scientific intervention of such traditional plants can be integrated to harmonise with modern medicine, to ensure its dosage and safety in augmenting disease management.

FROM A SIMPLE COLD SORE TO SEVERE CYSTIC LUNG DISEASE

CHEST Journal ◽  
2018 ◽  
Vol 154 (4) ◽  
pp. 156A
Author(s):  
RITU MODI ◽  
MARSHA ANTOINE ◽  
HASSAN AL KHALISY ◽  
BASHAR SHARMA ◽  
IOANA AMZUTA
Keyword(s):  
Lung Disease ◽  
Cold Sore ◽  
Cystic Lung ◽  
Cystic Lung Disease
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