scholarly journals Recombinant Ornithodoros moubata Saliva-derived Small Protein Complement C5 Inhibitor

2020 ◽  
Author(s):  
2018 ◽  
Author(s):  
Adrian Cernescu ◽  
Michał Szuwarzyński ◽  
Urszula Kwolek ◽  
Karol Wolski ◽  
Paweł Wydro ◽  
...  

<div><div>Scattering-mode Scanning Near-Field Optical Microscopy (sSNOM) allows one to obtain absorption spectra in the mid-IR region for samples as small as 20 nm in size. This configuration has made it possible to measure FTIR spectra of the protein complement of membranes. (Amenabar 2013) We now show that mid-IR sSNOM has the sensitivity required to measure spectra of phospholipids in individual bilayers in the spectral range 800 cm<sup>-1</sup>–1400 cm<sup>-1</sup>. We have observed the main absorption bands of the dipalmitoylphosphatidylcholine headgroups in this spectral region above noise level. We have also mapped the phosphate absorption band at 1070 cm<sup>-1</sup> simultaneously with the AFM topography. We have shown that we could achieve sufficient contrast to discriminate between single and multiple phospholipid bilayers and other structures, such as liposomes. This work opens the way to further research that uses nano-IR spectroscopy to describe the biochemistry of cell membranes and model systems.</div></div><div></div>


Author(s):  
Angeles C. Tecalco–Cruz

Abstract:: Human interferon–stimulated gene 15 (ISG15) is a 15–kDa ubiquitin–like protein that can be detected as either free ISG15 or covalently associated with its target proteins through a process termed ISGylation. Interestingly, extracellular free ISG15 has been proposed as a cytokine–like protein, whereas ISGylation is a posttranslational modification. ISG15 is a small protein with implications in some biological processes and pathologies that include cancer. This review highlights the findings of both free ISG15 and protein ISGylation involved in several molecular pathways, emerging as central elements in some cancer types.


1992 ◽  
Vol 153 (1) ◽  
pp. 31-39 ◽  
Author(s):  
Catherine Thompson-Coffe ◽  
Brett A. Wagner ◽  
Alan R. Orr

2021 ◽  
Vol 555 ◽  
pp. 175-181
Author(s):  
Honghui Wang ◽  
Jingjing Dong ◽  
Gaozhi Li ◽  
Yingjun Tan ◽  
Hai Zhao ◽  
...  

2020 ◽  
Vol 119 (3) ◽  
pp. 593-604
Author(s):  
John N. Werner ◽  
Handuo Shi ◽  
Jen Hsin ◽  
Kerwyn Casey Huang ◽  
Zemer Gitai ◽  
...  
Keyword(s):  

2021 ◽  
Vol 143 (3) ◽  
pp. 1447-1457
Author(s):  
Sandhya Bhatia ◽  
Guruswamy Krishnamoorthy ◽  
Jayant B. Udgaonkar

Author(s):  
Xiaofeng Cai ◽  
Caiyun Li ◽  
Koji Ichinose ◽  
Yali Jiang ◽  
Ming Liu ◽  
...  

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