Monte Carlo study of the dose enhancement effect of gold nanoparticles during X-ray therapies and evaluation of the anti-angiogenic effect on tumour capillary vessels

2013 ◽  
Vol 21 (2) ◽  
pp. 237-247 ◽  
Author(s):  
Ernesto Amato ◽  
Antonio Italiano ◽  
Salvatore Leotta ◽  
Stefano Pergolizzi ◽  
Lorenzo Torrisi
Keyword(s):  
Gold Nanoparticles ◽  
Monte Carlo ◽  
Monte Carlo Study ◽  
Enhancement Effect ◽  
Dose Enhancement ◽  
X Ray ◽  
Angiogenic Effect

scholarly journals A Monte Carlo study on the radio-sensitization effect of gold nanoparticles in brachytherapy of prostate by 103Pd seeds

2019 ◽  
Vol 25 (2) ◽  
pp. 87-92
Author(s):  
Amir Ghasemi Jangjoo ◽  
Hosein Ghiasi ◽  
Asghar Mesbahi
Keyword(s):  
Gold Nanoparticles ◽  
Monte Carlo ◽  
Tumor Volume ◽  
Monte Carlo Study ◽  
Enhancement Effect ◽  
Prostate Brachytherapy ◽  
Monte Carlo Code ◽  
Dose Enhancement ◽  
Computational Phantom ◽  
Good Agreement

Abstract 103Pd seed is being used for prostate brachytherapy. Additionally, the dose enhancement effect of gold nanoparticles (GNP) has been reported in previous studies. The aim of this study was to characterize the dosimetric effect of gold nanoparticles in brachytherapy with a 103Pd source. Two brachytherapy seeds including 103 Pd source was simulated using MCNPX Monte Carlo code. The seeds’ models were validated by comparing the MC with reported results. Then, GNPs (10 nm in diameter) with a concentration of 7mg Au/g were simulated uniformly inside the prostate of a humanoid computational phantom. Additionally, the dose enhancement factor (DEF) of nanoparticles was calculated for both modeled brachytherapy seeds. A good agreement was found between the MC calculated and the reported dosimetric parameters. For both seeds, an average DEF of 23% was obtained in tumor volume for prostate brachytherapy. The application of GNPs in conjunction with 103Pd seed in brachytherapy can enhance the delivered dose to the tumor and consequently leads to better treatment outcome.

Monte Carlo study on mega volt X-ray targets for dose enhancement

2015 ◽  
Vol 31 ◽  
pp. S8
Author(s):  
S. Mutsakanyi ◽  
F.C.P. Du Plessis
Keyword(s):  
Monte Carlo ◽  
Monte Carlo Study ◽  
Dose Enhancement ◽  
X Ray
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