TH-C-T-6C-04: Estimation of Tumor Dose Enhancement Due to Gold Nanoparticles During Typical Radiation Treatments: A Preliminary Monte Carlo Study

2005 ◽  
Vol 32 (6Part21) ◽  
pp. 2162-2162 ◽  
Author(s):  
S H Cho
Keyword(s):  
Gold Nanoparticles ◽  
Monte Carlo ◽  
Monte Carlo Study ◽  
Dose Enhancement ◽  
Radiation Treatments

A Monte Carlo study on tissue dose enhancement in brachytherapy: a comparison between gadolinium and gold nanoparticles

2012 ◽  
Vol 35 (2) ◽  
pp. 177-185 ◽  
Author(s):  
Mohammad Taghi Bahreyni Toossi ◽  
Mahdi Ghorbani ◽  
Mohammad Mehrpouyan ◽  
Fateme Akbari ◽  
Leila Sobhkhiz Sabet ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Monte Carlo ◽  
Monte Carlo Study ◽  
Dose Enhancement ◽  
Tissue Dose

scholarly journals A Monte Carlo study on the radio-sensitization effect of gold nanoparticles in brachytherapy of prostate by 103Pd seeds

2019 ◽  
Vol 25 (2) ◽  
pp. 87-92
Author(s):  
Amir Ghasemi Jangjoo ◽  
Hosein Ghiasi ◽  
Asghar Mesbahi
Keyword(s):  
Gold Nanoparticles ◽  
Monte Carlo ◽  
Tumor Volume ◽  
Monte Carlo Study ◽  
Enhancement Effect ◽  
Prostate Brachytherapy ◽  
Monte Carlo Code ◽  
Dose Enhancement ◽  
Computational Phantom ◽  
Good Agreement

Abstract 103Pd seed is being used for prostate brachytherapy. Additionally, the dose enhancement effect of gold nanoparticles (GNP) has been reported in previous studies. The aim of this study was to characterize the dosimetric effect of gold nanoparticles in brachytherapy with a 103Pd source. Two brachytherapy seeds including 103 Pd source was simulated using MCNPX Monte Carlo code. The seeds’ models were validated by comparing the MC with reported results. Then, GNPs (10 nm in diameter) with a concentration of 7mg Au/g were simulated uniformly inside the prostate of a humanoid computational phantom. Additionally, the dose enhancement factor (DEF) of nanoparticles was calculated for both modeled brachytherapy seeds. A good agreement was found between the MC calculated and the reported dosimetric parameters. For both seeds, an average DEF of 23% was obtained in tumor volume for prostate brachytherapy. The application of GNPs in conjunction with 103Pd seed in brachytherapy can enhance the delivered dose to the tumor and consequently leads to better treatment outcome.

An investigation of the effect of gold nanoparticles with different concentrations on increasing absorbed dose: an empirical and simulation study

2018 ◽  
Vol 18 (02) ◽  
pp. 191-197
Author(s):  
Masoumeh Hoseinnezhad ◽  
Mohammad Mahdavi ◽  
Seyyed R. M. Mahdavi ◽  
Mobarake Mahdavizade
Keyword(s):  
Monte Carlo Simulation ◽  
Gold Nanoparticles ◽  
Monte Carlo ◽  
Absorbed Dose ◽  
Simulation Method ◽  
Dose Enhancement ◽  
Depth Dose ◽  
Optical Ct ◽  
Ct System ◽  
Monte Carlo Simulation Model

AbstractPurposeThe purpose of this study was to determine the dose enhancement factor (DEF) of gold nanoparticles in a dosimeter gel and construct percentage depth dose curves, using the Optical CT system and the Monte Carlo simulation model, to determine the effect of increasing the dose caused by increasing the concentration of gold nanoparticles at depths in the gel.Materials and methodsThe Magic-f Gel was made based on the relevant protocol in the physics lab. To determine the amount of the increase in the absorbed dose, the gold nanoparticles were added to the gel and irradiated. An increase in the dose after adding nanoparticles to the gel vials was estimated both with the Optical CT system and by the Monte Carlo simulation method.ResultsDose enhancement curves for doses of 2, 4 and 6 Gy were prepared for gel vials without adding nanoparticles, and nanoparticle gels at concentrations 0·17, 3 and 6 mM. Also, the DEF was estimated. For the 0·17 mM molar gel, the DEF for 2, 4 and 6 Gy was 0·7, 0·743 and 0·801, respectively. For the 3 mM gel, it was 1·98, 2·5 and 2·2, and for the 6 mM gel, it was 37·4, 4·24 and 4·71, respectively.ConclusionThe enhancement of the dose after adding gold nanoparticles was confirmed both by experimental data and by simulation data.

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