Short-term vestibular responses to repeated rotations

2000 ◽  
Vol 10 (1) ◽  
pp. 17-23
Author(s):  
Seung Cheol Ahn ◽  
Chae Yong Lee ◽  
Dong Wook Kim ◽  
Moo Hoo Lee
Keyword(s):  
Time Constant ◽  
Phase Changes ◽  
Short Term ◽  
Mean Values ◽  
Ocular Reflex ◽  
Group I ◽  
Vestibulo Ocular Reflex ◽  
The Mean ◽  
Group Ii ◽  
Sinusoidal Rotations

To investigate the short-term vestibular habituation, we performed the 4 successive velocity step tests on 28 volunteers, the peak velocity of which was 100 deg/sec with acceleration and deceleration of 100 deg / sec 2 . As the repeated rotations might alter the vestibulo-ocular reflex (VOR), sinusoidal rotations at a frequency of 0.16 Hz were also given before and after the 4 successive velocity step tests to investigate the changes of gain and phase of VOR. The 28 volunteers were divided into two groups, group I and II, according to their responses to repeated rotations. In group I (25 subjects, mean age 23.7 year), the mean values of the slow cumulative eye position (SCEP), the time integral of eye velocity during nystagmus, was reduced after each trial of the 4-successive velocity step tests as follows; 403.4 ± 29 degree (1st trial), 346.2 ± 37 degree (2nd trial), 278.3 ± 33 degree (3rd trial) and 256.6 ± 36 degree (4th trial). The time constant of the nystagmus was also reduced as follows; 12.9 ± 0.78 second (1st trial), 12 ± 0.63 second (2nd trial), 9.7 ± 0.78 second (3rd trial) and 9.9 ± 0.54 second (4th trial). In group II (3 subjects, mean age 28.3 year), the mean values of SCEP gradually increased; 774.3 ± 135 degree (1st trial), 1127 ± 178 degree (2nd trial), 1096.3 ± 123.4 degree (3rd trial) and 1225.7 ± 199.7 degree (4th trial). The time constant of the nystagmus increased; 15.7 ± 2.7 second (1st trial), 22 ± 4.5 second (2nd trial), 22.3 ± 3.3 second (3rd trial) and 23.3 ± 5.7 second (4th trial). The gain of vestibulo-ocular reflex (VOR) induced by sinusoidal rotations at a frequency 0.16 Hz increased in both groups: 0.59 ± 0.03 to 0.78 ± 0.06 (group I) and 0.65 ± 0.07 to 1.15 ± 0.06 (group II). Phase changes were also observed. In group I, the phase was shifted from 0.6 ± 0.6 degree to − 0.40 ± 0.6 degree. In group II, the phase was shifted from 3.67 ± 1.86 degree to − 0.33 ± 0.33 degree. The repeated rotation did not induce a common nystagmic response in all subjects. Thus, person to person variations should be considered in short term vestibular habituation.

Acoustic Rhinometry of Asian Noses

2008 ◽  
Vol 22 (6) ◽  
pp. 617-620 ◽  
Author(s):  
Pongsakorn Tantilipikorn ◽  
Perapun Jareoncharsri ◽  
Siriporn Voraprayoon ◽  
Chaweewan Bunnag ◽  
Peter A. Clement
Keyword(s):  
Reference Value ◽  
Acoustic Rhinometry ◽  
Cross Sectional ◽  
Mean Values ◽  
Thai Subjects ◽  
Group I ◽  
The Mean ◽  
Group Ii ◽  
Black Populations ◽  
Female Subjects

Background Each ethnic group has different nasal cavity geometries. The reference value of the minimal cross-sectional area (MCA) and the nasal volume (NV) is mandatory for rhinologic evaluation in regular practice and for research. This study was designed to study the normal value of acoustic rhinometry (AR) in Asian subjects in comparison with other ethnic groups. Methods AR was performed in 135 healthy Thai subjects. Subjects were divided into two groups: group I, with normal anterior rhinoscopic appearance; group II included subjects with asymptomatic, slightly deviated nasal septa. Results The mean of the MCA was 0.61 ± 0.60 cm2 before decongestion and 0.64 ± 0.14 cm2 after decongestion. The mean distance from the nostril to the point of MCA (D) was 1.66 ± 0.59 cm before decongestion and 1.41 ± 0.74 cm after decongestion. The mean of the NV measured between 0 and 4 cm was 3.66 ± 0.67 cm3 before decongestion and 4.18 ± 0.75 cm3 after decongestion. Before decongestion, there were no significant differences in the mean of the MCA, D, and NV between group I and group II subjects; however, there were significant differences in mean MCA and NV after decongestion. There were no differences in the parameters between male and female subjects before decongestion, except for the D, but after decongestion the mean values of the MCA, D, and NV were significantly higher in male subjects compared with female subjects. Conclusion The results of this study can be used as a reference value for Asian ethnicities. Thai subjects had measurements comparable with those of the European study and somewhat different from the study in black populations.

scholarly journals Assessment of Oral Hygiene in Patients Using Fixed and Removable Dentures Treated at the University Dental Clinic in Krakow

2021 ◽  
Vol 18 (22) ◽  
pp. 11986
Author(s):  
Joanna Ryniewicz ◽  
Magdalena Orczykowska ◽  
Krzysztof Gronkiewicz ◽  
Małgorzata Pihut
Keyword(s):  
Oral Hygiene ◽  
Access To Health Care ◽  
Plaque Index ◽  
Dental Clinic ◽  
Mean Values ◽  
Group I ◽  
The Mean ◽  
Group Ii ◽  
The University ◽  
Dental Prosthetics

Apart from local lesions, the presence of dental plaque may also have an effect on health, especially in people with general diseases. The aim of this project was to assess the oral hygiene of patients prosthetically treated at the Dental Prosthetics Clinic of the University Dental Clinic in Krakow (Poland) using fixed and removable dentures and to determine the demographic relationships and data related to the education of the respondents. The research material consisted of 120 patients who used fixed (group I) and removable (group II) restorations. Basic dental examinations and oral hygiene examinations were carried out with the use of the API (Approximal Plaque Index) and PI (Plaque Index) plaque indices. This study presents the percentage of respondents in terms of sex, place of residence, and education. The mean PI (plaque index) values were 46.73% (Group I) and 50.05% (Group II). (p = 0.4839). The mean values of API (Approximal Plaque Index) amounted to 65.14% (Group I) and 68.94% (Group II) (p = 0.4695). Patients using dentures showed insufficient oral hygiene, and the hygiene status of patients did not depend on the type of dentures used. The group that is most often treated with prosthetics is women with secondary education. The most numerous group of patients at the Dental Prosthetics Clinic are people living in large cities which results from easier access to health care.

Labiolingual and mesiodistal positioning of maxillary permanent incisors during the eruption process

2001 ◽  
Vol 25 (1) ◽  
pp. 13-21 ◽  
Author(s):  
Osmar Aparecido Cuoghi ◽  
Francisco Antonio Bertoz ◽  
Marcos Rogerio de Mendonca ◽  
Eduardo Cesar Almada Santos ◽  
An Tien Li
Keyword(s):  
Mixed Dentition ◽  
Mean Values ◽  
Group Iii ◽  
Lower Border ◽  
Group I ◽  
Normal Occlusion ◽  
The Mean ◽  
Group Ii

This study aimed to establish radiographical parameters concerning the tipping, the labiolingual positioning and the angulation of the maxillary permanent incisors in the mixed dentition. Three groups of 20 cephalograms and 20 orthopantomographic radiographs taken from children aging from 7 to 12 years old, with normal occlusion were compared. The Group I presented only the eruption of the central permanent incisors, the Group II presented both the central and lateral permanent incisors and the Group III presented central, lateral incisors and permanent canine teeth. The tipping and the labiolingual positioning were measured, respectively, using U1/PP and U1↔AVERT. Mesiodistally, the angles between the teeth axis and the line that touched the lower border of the orbit in the orthopantomographic radiographs were measured. The mean values of tipping, labiolingual positioning and angulation of the central and lateral incisors obtained from Groups I, II and III were respectively 112°, 1.2mm, 90.4° and 91.7°; 112°, 2.6mm, 89.5° and 96.8° and. 114°, 2.7mm, 87.4° and 92.6°. The tipping levels were similar for all groups, the mean values of the labiolingual positioning were significantly different at 5% when Group I was compared to both Groups II and III.And the mean values of the angulation were significantly different 5% for the central incisors between Groups I and III, and at 1% for the lateral incisors between Groups I and II, and, II and III.

scholarly journals Multidisciplinary approach in combating childhood obesity

2016 ◽  
Vol 3 (1) ◽  
Author(s):  
Dr.G. G. Kavitha Shree ◽  
Dr.M.R. Premalatha ◽  
Dr.K. Jothilakshmi
Keyword(s):  
Childhood Obesity ◽  
Behavioral Intervention ◽  
Education Program ◽  
Short Term ◽  
Group I ◽  
The Mean ◽  
Group Ii ◽  
Significant Change ◽  
One Year

The study demonstrated the beneficial effect of a multidisciplinary dietary-behavioral-physical intervention on childhood obesity among totally selected 618 school children. Children were classified as Group-I who received both education program and fitness exercise (N=228- Long-term behavioral intervention) and Group-II who were exposed only to education program (N=390 Short-term behavioral intervention). It was found that 28.3 per cent were overweight and 7.9 per cent were obese as per International Obesity Task Force (IOTF) standards at the beginning of study. The initial mean Body Mass Index (BMI) was 21.6+3.9 in Group-I and 21.9+3.4 in Group-II. The BMI reduced to 21.4+3.8 in Group-I and 21.8+3.5 in Group-II after six months at the first phase. After one year, the mean BMI of Group-I reduced significantly to 20.8+ 3.5 (P = 0.0001) due to long-term interventions, whereas the mean BMI of Group-II increased after one year. There was significant reduction in Waist Hip Ratio from initial to final among Group-I alone. There was no significant change in the Pulse Rate among both groups at the end of the study. After one year, among Group-I children, 6.6 per cent with high Blood Pressure and 4.4 per cent who had low BP shifted to normal BP showing a significant change whereas there was no significant change in Group-II. Peak expiratory flow rate improved significantly only in Group-I. There was significant influence of fitness exercise intervention on the fitness level test scores among Group-I after one year but there was no significant changes in Group-II. Thus the study revealed that only long-term combined multidisciplinary interventions can have positive influence in combating childhood obesity than short-term interventions.

scholarly journals Short-term Comparison of Refractive Errors between Two Different Age Groups after LASEK for Moderate Myopia

2021 ◽  
Vol 62 (11) ◽  
pp. 1478-1482
Author(s):  
Mi Jeong Kim ◽  
Ji Seon An ◽  
Ja Yoon Moon ◽  
Hee Young Kim ◽  
Jin Seok Choi ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Age Groups ◽  
Refractive Errors ◽  
Age Group ◽  
Short Term ◽  
Corrected Visual Acuity ◽  
Group I ◽  
The Mean ◽  
Group Ii

Purpose: To investigate the safety of laser epithelial keratomileusis (LASEK) by drawing a comparison between two groups divided according to age (18-19 vs. 20-21 years old).Methods: The study was conducted as a retrospective analysis including 339 patients (678 eyes) who underwent LASEK between January 2017 and April 2020. Patients were divided by age group, group I (18-19 years old) and group II (20-21 years old). The objectives of the study included determination of visual acuity and refractive errors before and at 1, 3, and 6 months after the procedure.Results: The preoperative mean spherical equivalents (SEs) were -4.73 ± 0.88 diopters (D) in group I and -4.58 ± 0.87 D in group II (p = 0.34). At 1 month postoperatively, mean SEs were 0.32 ± 0.46 D in group I and 0.26 ± 0.59 D in group II (p = 0.18). At 3 months postoperatively, the mean SEs were 0.30 ± 0.47 D in group I and 0.28 ± 0.50 D in group II (p = 0.67). At 6 months postoperatively, the mean SEs were 0.15 ± 0.47 D in group I and 0.14 ± 0.50 D in group II (p = 0.89). There were no significant differences in postoperative best corrected visual acuity between group I and group II at 1, 3, or 6 months (p = 0.20, p = 0.13, and p = 0.11, respectively).Conclusions: There were no significant differences in postoperative mean SE or safety of LASEK between moderate myopia patients 18-19 years old and those 20-21 years old.

Effect of the short-term progestagen treatments plus PMSG prior ram introduction on the estrus synchronization and the fertility of Ile de France ewes

2011 ◽  
Vol 27 (3) ◽  
pp. 1157-1166 ◽  
Author(s):  
N. Metodiev ◽  
E. Raicheva
Keyword(s):  
Control Group ◽  
Estrus Synchronization ◽  
Mating Season ◽  
Short Term ◽  
Group I ◽  
Group Control ◽  
The Mean ◽  
Group Ii ◽  
In The Beginning

The aim of the present study was to evaluate the effect of the short-term progestagen treatments plus PMSG prior ram introduction on the estrus synchronization and the fertility of Ile de France ewes in the beginning of mating season. The study was carried out with 36 pure-bred ewes (aged 4-6 years) during April 2009. The ewes were divided in 3 groups (n=12 for each group): group I - vaginal sponge impregnated with 30mg FGA for six days, as at the time of placement of sponge 125 ?g cloprostenolum was put i.m At the time of removal of the sponge 250 UI PMSG was put i.m.; group II- the same as the I group, but without cloprostenolum treatment: III group - control. The teasers were introduced to ewes 24h after the sponge removal and ewes in estrus was inseminated artificially. The following parameters were studied: effect of estrus synchronization (EES) ewes in estrus was recorded twice daily for the first 6 days after sponge removal; onset, end and duration of estrus for group I and II, fertility (at first estrus) and fecundity (calculated after lambing). The data for fertility and fecundity for the control group was obtained as ewes were fertilized during 30 days from the begging of the breeding. A significant effect of both schemes to estrus synchronization was determined F=33,33, P<0,001). The EES, fertility and fecundity for group I, II and III were - 91,66%, 63,64% and 142,0%; 91,66%, 45,45% and 140,0 %; 8,33%, 91,66% and 140,0% respectively. The mean onset, end and duration of estrus was 51,27 h, 77,45 h and 27,27h for the I group and 57,82h, 87,27h and 29,45 h respectively for the II group. We conclude that the scheme applied for the first group is better to use for estrus synchronization in the beginning of mating season.

scholarly journals Vectoelectronystagmography in children with dyslexia and learning disorder

Revista CEFAC ◽  
2018 ◽  
Vol 20 (4) ◽  
pp. 442-449 ◽  
Author(s):  
Ana Carla Leite Romero ◽  
Mariana Banzato Stenico ◽  
Letícia Sampaio de Oliveira ◽  
Eloisa Sartori Franco ◽  
Simone Aparecida Capellini ◽  
...  
Keyword(s):  
Optokinetic Nystagmus ◽  
Saccadic Eye Movements ◽  
Learning Disorders ◽  
Control Group ◽  
Learning Disorder ◽  
Group Iii ◽  
Ocular Reflex ◽  
Group I ◽  
Vestibulo Ocular Reflex ◽  
Group Ii

ABSTRACT Objective: to describe and compare the results of ocular (saccadic, screening, and optokinetic) tests of vectoelectronystagmography among the groups with dyslexia, learning disorder and control. Methods: 28 male and female students aged 8 to 11 years participated in this study. They were divided into three groups: Group I, 10 students with dyslexia, Group II, 9 students with learning disorders and Group III, 9 students with no learning disorders. In this research, digital vectoelectronystagmography - ocular test - was performed. Results: saccadic movement, optokinetic nystagmus, and pendular tracking tests were found to show subtle differences among the three groups. Comparing the saccadic eye movements and the optokinetic nystagmus tests, it was observed that the movement in the left eye was slower for Group I, and even slower for Group II. It was also observed that GI and GII were slower for the pendular tracking of luminous stimulus in relation to the control group. Conclusion: in general, there are differences among the groups in the vectoelectronystagmography, which indicated slower tracking and vestibulo-ocular reflex in children with dyslexia and learning disorders.

Vitamin B3 (Niacin) in Diet Act as Protective Negotiator for Development of Myocardial Infarction

2021 ◽  
Vol 15 (5) ◽  
pp. 1127-1129
Author(s):  
A. R. Memon ◽  
M. Akram ◽  
U. Bhatti ◽  
A. S. Khan ◽  
K. Rani ◽  
...  
Keyword(s):  
Angina Pectoris ◽  
Statin Therapy ◽  
Serum Cholesterol ◽  
Hdl Cholesterol ◽  
Vitamin B3 ◽  
Mean Values ◽  
Cholesterol Levels ◽  
Group I ◽  
The Mean ◽  
Group Ii

Background: Vitamin B3 (Niacin) is known to decrease LDL‐cholesterol, and triglycerides, and increase HDL‐cholesterol levels. The evidence of benefits with niacin monotherapy or add‐on to statin‐based therapy is controversial. Aim: To determine the effects of vitamin B3 with statins on lipid profile of patients of angina pectoris with dyslpidemia. Study Design: Randomized control trial study. Place and Duration of Study: Department of Biochemistry, Shaikha Fatima Institute of Nursing & Health Sciences (SFINHS), Lahore with collaboration of Cardiology OPD of Shaikh Zayed Hospital Lahore from 1st November 2019 to 31st January 2020. Methodology: Seventy four diagnosed cases of angina pectoris with dyslipidemia were recruited with age range from 30 to 50 years. They were divided into two groups; Group I contained 36 patients as controlled group which was given treatment of angina with Tab. Rovista (statin) 10mg at dinner for treatment of dyslipidemia and Group II contained 38 patients as case study group which was given treatment of angina with Tab. Rovista (statin) 10 mg at dinner and tablet Vitamin B3 500 mg with single OD dose at day time for treatment of dyslipidemia for 8 weeks. Results: The mean serum cholesterol levels at zero level (before the start of treatment) of group I was 244 mg/dl and group II was 246 mg/dl, LDL of group I was 169 mg/dl while group II was 170 mg/dl and HDL of group I was 20 mg/dl while group II was 19 mg/dl . After the treatment group I which taken only statins for treatment of dyslipidemia the mean serum cholesterol levels was 210 mg/dl, LDL was 144 mg/dl and HDL was 26 mg/dl while the mean values of group II (taken statin as well as vitamin B3) serum cholesterol level was 192 mg/dl, LDL was 122 mg/dl and HDL was 44 mg/dl. The results shown there were significant effects of statin therapy along with vitamin B3 on serum LDL and serum HDL levels. Conclusion: There were significant effects of statin therapy along with vitamin B3 on serum LDL and Serum HDL levels. Key Words: Vitamin B3, Serum Cholesterol, Serum LDL &HDL

scholarly journals High-dose MTX110 (soluble panobinostat) safely administered into the fourth ventricle in a nonhuman primate model

2020 ◽  
Vol 26 (2) ◽  
pp. 127-135 ◽  
Author(s):  
David I. Sandberg ◽  
Natasha Kharas ◽  
Bangning Yu ◽  
Christopher F. Janssen ◽  
Amanda Trimble ◽  
...  
Keyword(s):  
Fourth Ventricle ◽  
Nonhuman Primates ◽  
High Dose ◽  
Normal Brain ◽  
Short Term ◽  
Group I ◽  
Mri Scans ◽  
The Mean ◽  
Group Ii

OBJECTIVEChemotherapy infusions directly into the fourth ventricle may play a role in treating malignant fourth-ventricular tumors. This study tested the safety and pharmacokinetics of short-term and long-term administration of MTX110 (soluble panobinostat; Midatech Pharma) into the fourth ventricle of nonhuman primates.METHODSFour rhesus macaque monkeys underwent posterior fossa craniectomy and catheter insertion into the fourth ventricle. In group I (n = 2), catheters were externalized and lumbar drain catheters were placed simultaneously to assess CSF distribution after short-term infusions. MTX110 (0.5 ml of 300 μM panobinostat solution) was infused into the fourth ventricle daily for 5 consecutive days. Serial CSF and serum panobinostat levels were measured. In group II (n = 2), fourth-ventricle catheters were connected to a subcutaneously placed port for subsequent long-term infusions. Four cycles of MTX110, each consisting of 5 daily infusions (0.5 ml of 300 μM panobinostat solution), were administered over 8 weeks. Animals underwent detailed neurological evaluations, MRI scans, and postmortem histological analyses.RESULTSNo neurological deficits occurred after intraventricular MTX110 infusions. MRI scans showed catheter placement within the fourth ventricle in all 4 animals, with extension to the cerebral aqueduct in 1 animal and into the third ventricle in 1 animal. There were no MRI signal changes in the brainstem, cerebellum, or elsewhere in the brains of any of the animals. Histologically, normal brain cytoarchitecture was preserved with only focal mild postsurgical changes in all animals. Panobinostat was undetectable in serum samples collected 2 and 4 hours after infusions in all samples in both groups. In group I, the mean peak panobinostat level in the fourth-ventricle CSF (6242 ng/ml) was significantly higher than that in the lumbar CSF (9 ng/ml; p < 0.0001). In group II, the mean peak CSF panobinostat level (11,042 ng/ml) was significantly higher than the mean trough CSF panobinostat level (33 ng/ml; p < 0.0001).CONCLUSIONSMTX110 can be safely infused into the fourth ventricle in nonhuman primates at supratherapeutic doses. Postinfusion CSF panobinostat levels peak immediately in the fourth ventricle and then rapidly decrease over 24 hours. Panobinostat is detectable at low levels in CSF measured from the lumbar cistern up to 4 hours after infusions. These results will provide background data for a pilot clinical trial in patients with recurrent medulloblastoma.

Dynamics of the human linear vestibulo-ocular reflex at medium frequency and modification by short-term training

2000 ◽  
Vol 10 (6) ◽  
pp. 271-282 ◽  
Author(s):  
Mark Shelhamer ◽  
Dale C. Roberts ◽  
David S. Zee
Keyword(s):  
Slow Component ◽  
Phase Changes ◽  
Slow Phase ◽  
Medium Frequency ◽  
Short Term ◽  
Ocular Reflex ◽  
Short Term Adaptation ◽  
Vestibulo Ocular Reflex ◽  
Catch Up ◽  
Saccadic Responses

We study here the effect of a short-term training paradigm on the gain and phase of the human translational VOR (the linear VOR: LVOR). Subjects were exposed to lateral sinusoidal translations on a sled, at 0.5 Hz, 0.3 g peak acceleration. With subjects tracking a remembered target at 1.2 m, the LVOR (slow-phase) under these conditions typically has a phase lead or lag, and a gain that falls short of compensatory. To induce short-term adaptation (training), we presented an earth-fixed visual scene at 1.2 m during sinusoidal translation ( × 1 viewing) for 20 minutes, so as to drive the LVOR toward compensatory phase and gain. We examined both the slow-phase and the saccadic responses to these stimuli. Testing after training showed changes in slow-component gain and phase which were mostly but not always in the compensatory direction. These changes were more consistent in naive subjects than in subjects who had previous LVOR experience. Changes in gain were seen with step as well as sinusoidal test stimuli; gain changes were not correlated with vergence changes. There was a strong correlation between gain changes and phase changes across subjects. Fast phases (catch-up saccades) formed a large component of the LVOR under our testing conditions (approximately 30% of the changes in gain but not in phase due to training.

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