The effect of low magnitude mechanical stimulation (LMMS) on bone density in patients with Rett syndrome: A pilot and feasibility study

2014 ◽  
Vol 7 (2) ◽  
pp. 167-178 ◽  
Author(s):  
Sarah Y. Afzal ◽  
Anna R. Wender ◽  
Mary D. Jones ◽  
Ellen B. Fung ◽  
Elaine L. Pico
Keyword(s):  
Bone Density ◽  
Rett Syndrome ◽  
Feasibility Study ◽  
Mechanical Stimulation ◽  
Low Magnitude

scholarly journals Low-Magnitude Mechanical Stimulation to Improve Bone Density in Persons of Advanced Age: A Randomized, Placebo-Controlled Trial

2015 ◽  
Vol 30 (7) ◽  
pp. 1319-1328 ◽  
Author(s):  
Douglas P Kiel ◽  
Marian T Hannan ◽  
Bruce A Barton ◽  
Mary L Bouxsein ◽  
Emily Sisson ◽  
...  
Keyword(s):  
Bone Density ◽  
Mechanical Stimulation ◽  
Controlled Trial ◽  
Advanced Age ◽  
Low Magnitude

A Three-year randomized sham-controlled trial of low magnitude mechanical stimulation in an elderly sample: the ‘VIBES' trial

2013 ◽  
Author(s):  
Douglas Kiel ◽  
Marian Hannan ◽  
Emily Sisson ◽  
Mary Bouxsein ◽  
Bruce Barton ◽  
...  
Keyword(s):  
Mechanical Stimulation ◽  
Controlled Trial ◽  
Low Magnitude

scholarly journals Influence of high-frequency cyclical stimulation on the bone fracture-healing process: mathematical and experimental models

2011 ◽  
Vol 369 (1954) ◽  
pp. 4278-4294 ◽  
Author(s):  
María José Gómez-Benito ◽  
Libardo Andrés González-Torres ◽  
Esther Reina-Romo ◽  
Jorge Grasa ◽  
Belén Seral ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Bone Healing ◽  
Mechanical Stimulation ◽  
Bone Fracture ◽  
High Frequency ◽  
Endochondral Ossification ◽  
Healing Process ◽  
Bone Fracture Healing ◽  
Bone Healing Process ◽  
Low Magnitude

Mechanical stimulation affects the evolution of healthy and fractured bone. However, the effect of applying cyclical mechanical stimuli on bone healing has not yet been fully clarified. The aim of the present study was to determine the influence of a high-frequency and low-magnitude cyclical displacement of the fractured fragments on the bone-healing process. This subject is studied experimentally and computationally for a sheep long bone. On the one hand, the mathematical computational study indicates that mechanical stimulation at high frequencies can stimulate and accelerate the process of chondrogenesis and endochondral ossification and consequently the bony union of the fracture. This is probably achieved by the interstitial fluid flow, which can move nutrients and waste from one place to another in the callus. This movement of fluid modifies the mechanical stimulus on the cells attached to the extracellular matrix. On the other hand, the experimental study was carried out using two sheep groups. In the first group, static fixators were implanted, while, in the second one, identical devices were used, but with an additional vibrator. This vibrator allowed a cyclic displacement with low magnitude and high frequency (LMHF) to be applied to the fractured zone every day; the frequency of stimulation was chosen from mechano-biological model predictions. Analysing the results obtained for the control and stimulated groups, we observed improvements in the bone-healing process in the stimulated group. Therefore, in this study, we show the potential of computer mechano-biological models to guide and define better mechanical conditions for experiments in order to improve bone fracture healing. In fact, both experimental and computational studies indicated improvements in the healing process in the LMHF mechanically stimulated fractures. In both studies, these improvements could be associated with the promotion of endochondral ossification and an increase in the rate of cell proliferation and tissue synthesis.

scholarly journals Effects of low-magnitude, high-frequency mechanical stimulation in the rat osteopenia model

2009 ◽  
Vol 20 (12) ◽  
pp. 1999-2008 ◽  
Author(s):  
S. Sehmisch ◽  
R. Galal ◽  
L. Kolios ◽  
M. Tezval ◽  
C. Dullin ◽  
...  
Keyword(s):  
Mechanical Stimulation ◽  
High Frequency ◽  
Low Magnitude

scholarly journals Role of CaMKK2 in Mechanically Induced Bone Formation

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Adam J. Warrick ◽  
Uma Sankar
Keyword(s):  
Protein Kinase ◽  
Bone Density ◽  
Bone Formation ◽  
Mechanical Stimulation ◽  
Internal Control ◽  
Molecular Mechanisms ◽  
Bone Growth ◽  
Lower Limbs ◽  
Alizarin Red ◽  
Bone Formation Rate

Background and Hypothesis: Mechanical stimulation of bone results in the translation of external forces into a cascade of structural and biochemical changes which work to increase bone density and decrease fracture healing time. The specific mechanisms contributing to these processes are areas of active investigation. Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) is a serine-threonine protein kinase with key roles in both the anabolic and catabolic pathways of bone remodeling. We hypothesize that the absence of CaMKK2 potentiates an increase in bone density as a response to mechanical stimulation. Experimental Design or Project Methods: The right ulna of anesthetized C57BL/6 mice were loaded for 220 cycles at 2 Hz and with peak forces specific to both sex and genotype. Loading was completed using an electro actuator (Bose ElectroForce 3200; EnduraTEC, Minnetonka, MN, USA) and was repeated on days 3, 5, 8 and 10 after the initial procedure. The non-loaded left ulna served as an internal control. Calcein and alizarin red were administered intraperitoneally on days 9 and 16 respectively. Mice were sacrificed on day 19 after the initial load; blood and long bones of the lower limbs were collected for analysis. Results: Bone volumetric analyses will be measured using microcomputed tomography, bone formation rate will be assessed using dynamic histomorphometry measurements of double fluorochrome labeling, and cellular and molecular mechanisms will be assessed using histology, immunohistochemistry and real-time reverse transcription-polymerase chain reaction. These data are currently forthcoming. Conclusion and Potential Impact: Clinical outcomes of conditions ranging from stress fractures to osteoporosis may be improved by an increased understanding of the mechanisms through which bone growth is augmented. Expanded knowledge of these pathways may provide opportunities for the development of novel therapies which decrease healing times in the event of injury and increase bone density to combat degenerative disease states.

scholarly journals THE SIMULATION OF MECHANICAL STIMULATION EFFECT ON BONE ELASTICITY LIMIT BASED ON FINITE ELEMENT METHOD (FEM)

2021 ◽  
Vol 83 (3) ◽  
pp. 21-27
Author(s):  
Khusnul Yakin ◽  
Ita Setyaningsih ◽  
Nurani Indha Rusmana ◽  
Mohammad Tirono ◽  
Rofiqul Umam
Keyword(s):  
Bone Density ◽  
Strain Rate ◽  
Mechanical Stimulation ◽  
Stress And Strain ◽  
Mechanical Stimuli ◽  
Elasticity Limit ◽  
Bone Properties ◽  
Strain And Strain Rate ◽  
Reversal Phase ◽  
The Difference

Osteoporosis is a disease  affecting bones which is characterized by decreased bone density;  bones become porous and  susceptible to fractures. Osteoporosis occurs because of an imbalance during bone remodeling phase between resorption and formation processes. This study aims to simulate the effects of mechanical stimulations on the femoral bone elasticity limit. It is hoped that these mechanical stimuli can provide information on bone elasticity limits. Initially, we constructed the femur in two layers using triangular elements. Then we entered the bone properties (Young’s modulus and Poisson’s ratio) based on the age of the femur. After that we  calculated the value of the stress, strain, and strain rate in the reversal phase. Next, we calculated the  bone density using the thermodynamic equation and calculation of the bone elasticity limit using particle swarm optimization (PSO) methods. The value of stress and strain caused by walking is higher than the value of stress and strain when standing still. In this case, the difference in activity results an increase in stress by 33.82% and an increase in strain and strain rate by 34.57%. Based on these simulation results, it can be concluded that mechanical stimulation can increase the limit of bone elasticity to 2.99% in cortical bone and 0.975% in trabecular bone. Bone elasticity limit can be used to determine the level of osteoporosis that occurs. The higher value of the bone elasticity, the smaller the possibility of osteoporosis.

scholarly journals Effect of Low-Magnitude Mechanical Stimuli on Bone Density and Structure in Pediatric Crohn's Disease: A Randomized Placebo-Controlled Trial

2016 ◽  
Vol 31 (6) ◽  
pp. 1177-1188 ◽  
Author(s):  
Mary B Leonard ◽  
Justine Shults ◽  
Jin Long ◽  
Robert N Baldassano ◽  
J Keenan Brown ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Bone Density ◽  
Crohn's Disease ◽  
Controlled Trial ◽  
Mechanical Stimuli ◽  
Low Magnitude

A Comparison of Lumbar Spine and Lateral Distal Femur Bone Density in Girls With Rett Syndrome

2020 ◽  
Author(s):  
Emily W. Gripp ◽  
H. Theodore Harcke ◽  
Steven J. Bachrach ◽  
Heidi H. Kecskemethy
Keyword(s):  
Lumbar Spine ◽  
Bone Density ◽  
Rett Syndrome ◽  
Distal Femur ◽  
Femur Bone
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