A Three-year randomized sham-controlled trial of low magnitude mechanical stimulation in an elderly sample: the ‘VIBES' trial

2013 ◽  
Author(s):  
Douglas Kiel ◽  
Marian Hannan ◽  
Emily Sisson ◽  
Mary Bouxsein ◽  
Bruce Barton ◽  
...  
Keyword(s):  
Mechanical Stimulation ◽  
Controlled Trial ◽  
Low Magnitude

scholarly journals Low-Magnitude Mechanical Stimulation to Improve Bone Density in Persons of Advanced Age: A Randomized, Placebo-Controlled Trial

2015 ◽  
Vol 30 (7) ◽  
pp. 1319-1328 ◽  
Author(s):  
Douglas P Kiel ◽  
Marian T Hannan ◽  
Bruce A Barton ◽  
Mary L Bouxsein ◽  
Emily Sisson ◽  
...  
Keyword(s):  
Bone Density ◽  
Mechanical Stimulation ◽  
Controlled Trial ◽  
Advanced Age ◽  
Low Magnitude

The effect of low magnitude mechanical stimulation (LMMS) on bone density in patients with Rett syndrome: A pilot and feasibility study

2014 ◽  
Vol 7 (2) ◽  
pp. 167-178 ◽  
Author(s):  
Sarah Y. Afzal ◽  
Anna R. Wender ◽  
Mary D. Jones ◽  
Ellen B. Fung ◽  
Elaine L. Pico
Keyword(s):  
Bone Density ◽  
Rett Syndrome ◽  
Feasibility Study ◽  
Mechanical Stimulation ◽  
Low Magnitude

scholarly journals Influence of high-frequency cyclical stimulation on the bone fracture-healing process: mathematical and experimental models

2011 ◽  
Vol 369 (1954) ◽  
pp. 4278-4294 ◽  
Author(s):  
María José Gómez-Benito ◽  
Libardo Andrés González-Torres ◽  
Esther Reina-Romo ◽  
Jorge Grasa ◽  
Belén Seral ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Bone Healing ◽  
Mechanical Stimulation ◽  
Bone Fracture ◽  
High Frequency ◽  
Endochondral Ossification ◽  
Healing Process ◽  
Bone Fracture Healing ◽  
Bone Healing Process ◽  
Low Magnitude

Mechanical stimulation affects the evolution of healthy and fractured bone. However, the effect of applying cyclical mechanical stimuli on bone healing has not yet been fully clarified. The aim of the present study was to determine the influence of a high-frequency and low-magnitude cyclical displacement of the fractured fragments on the bone-healing process. This subject is studied experimentally and computationally for a sheep long bone. On the one hand, the mathematical computational study indicates that mechanical stimulation at high frequencies can stimulate and accelerate the process of chondrogenesis and endochondral ossification and consequently the bony union of the fracture. This is probably achieved by the interstitial fluid flow, which can move nutrients and waste from one place to another in the callus. This movement of fluid modifies the mechanical stimulus on the cells attached to the extracellular matrix. On the other hand, the experimental study was carried out using two sheep groups. In the first group, static fixators were implanted, while, in the second one, identical devices were used, but with an additional vibrator. This vibrator allowed a cyclic displacement with low magnitude and high frequency (LMHF) to be applied to the fractured zone every day; the frequency of stimulation was chosen from mechano-biological model predictions. Analysing the results obtained for the control and stimulated groups, we observed improvements in the bone-healing process in the stimulated group. Therefore, in this study, we show the potential of computer mechano-biological models to guide and define better mechanical conditions for experiments in order to improve bone fracture healing. In fact, both experimental and computational studies indicated improvements in the healing process in the LMHF mechanically stimulated fractures. In both studies, these improvements could be associated with the promotion of endochondral ossification and an increase in the rate of cell proliferation and tissue synthesis.

scholarly journals Effects of low-magnitude, high-frequency mechanical stimulation in the rat osteopenia model

2009 ◽  
Vol 20 (12) ◽  
pp. 1999-2008 ◽  
Author(s):  
S. Sehmisch ◽  
R. Galal ◽  
L. Kolios ◽  
M. Tezval ◽  
C. Dullin ◽  
...  
Keyword(s):  
Mechanical Stimulation ◽  
High Frequency ◽  
Low Magnitude

scholarly journals Effect of Low-Magnitude Mechanical Stimuli on Bone Density and Structure in Pediatric Crohn's Disease: A Randomized Placebo-Controlled Trial

2016 ◽  
Vol 31 (6) ◽  
pp. 1177-1188 ◽  
Author(s):  
Mary B Leonard ◽  
Justine Shults ◽  
Jin Long ◽  
Robert N Baldassano ◽  
J Keenan Brown ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Bone Density ◽  
Crohn's Disease ◽  
Controlled Trial ◽  
Mechanical Stimuli ◽  
Low Magnitude

scholarly journals The long-term residual effects of low-magnitude mechanical stimulation therapy on skeletal health

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Kyle A. Bodnyk ◽  
Kyle S. Kuchynsky ◽  
Megan Balgemann ◽  
Brooke Stephens ◽  
Richard T. Hart
Keyword(s):  
Mechanical Stimulation ◽  
Residual Effects ◽  
Skeletal Health ◽  
Low Magnitude
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