scholarly journals Imaging and neuropsychological correlates of white matter lesions in different subtypes of Mild Cognitive Impairment: A systematic review

2017 ◽  
Vol 41 (1) ◽  
pp. 189-204 ◽  
Author(s):  
Charlene L.M. Lam ◽  
Jenny Yiend ◽  
Tatia M.C. Lee
Keyword(s):  
Systematic Review ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
White Matter Lesions ◽  
Neuropsychological Correlates

scholarly journals Education Modulates the Impact of White Matter Lesions on the Risk of Mild Cognitive Impairment and Dementia

2014 ◽  
Vol 22 (11) ◽  
pp. 1336-1345 ◽  
Author(s):  
Marion Mortamais ◽  
Florence Portet ◽  
Adam M. Brickman ◽  
Frank A. Provenzano ◽  
Jordan Muraskin ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
White Matter Lesions ◽  
The Impact

scholarly journals Do cerebral white matter lesions influence the rate of progression from mild cognitive impairment to dementia?

2012 ◽  
Vol 25 (1) ◽  
pp. 120-127 ◽  
Author(s):  
Michael E. Devine ◽  
J. Andres Saez Fonseca ◽  
Zuzana Walker
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
White Matter Lesions ◽  
Cerebral White Matter ◽  
Brain Scans ◽  
Mri Brain ◽  
Cerebral White Matter Lesions ◽  
Ct And Mri

ABSTRACTBackground: Cerebral white matter lesions (WML), evident on CT and MRI brain scans, are histopathologically heterogeneous but associated with vascular risk factors and thought mainly to indicate ischemic damage. There has been disagreement over their clinical prognostic value in predicting conversion from mild cognitive impairment (MCI) to dementia.Methods: We scrutinised and rated CT and MRI brain scans for degree of WML in a memory clinic cohort of 129 patients with at least 1 year of follow-up. We examined the relationship between WML severity and time until conversion to dementia for all MCI patients and for amnestic (aMCI) and non-amnestic (naMCI) subgroups separately.Results: Five-year outcome data were available for 87 (67%) of the 129 patients. The proportion of patients converting to dementia was 25% at 1 year and 76% at 5 years. Patients with aMCI converted to dementia significantly earlier than those with naMCI. WML severity was not associated with time to conversion to dementia for either MCI patients in general or aMCI patients in particular. Among naMCI patients, there was a tendency for those with a low degree of WML to survive without dementia for longer than those with a high degree of WML. However, this was not statistically significant.Conclusions: MCI subtype is a significant independent predictor of conversion to dementia, with aMCI patients having higher risk than naMCI for conversion throughout the 5-year follow-up period. WML severity does not influence conversion to dementia for aMCI but might accelerate progression in naMCI.

scholarly journals White-matter lesions along the cholinergic tracts are related to cortical sources of EEG rhythms in amnesic mild cognitive impairment

2009 ◽  
Vol 30 (5) ◽  
pp. 1431-1443 ◽  
Author(s):  
Claudio Babiloni ◽  
Michela Pievani ◽  
Fabrizio Vecchio ◽  
Cristina Geroldi ◽  
Fabrizio Eusebi ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
White Matter Lesions ◽  
Eeg Rhythms ◽  
Cortical Sources ◽  
Amnesic Mild Cognitive Impairment

White matter lesions and the cholinergic deficit in aging and mild cognitive impairment

2017 ◽  
Vol 53 ◽  
pp. 27-35 ◽  
Author(s):  
Nils Richter ◽  
Anne Michel ◽  
Oezguer A. Onur ◽  
Lutz Kracht ◽  
Markus Dietlein ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
White Matter Lesions ◽  
Cholinergic Deficit

scholarly journals Spatial Distribution of Cerebral White Matter Lesions Predicts Progression to Mild Cognitive Impairment and Dementia

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e56972 ◽  
Author(s):  
Marion Mortamais ◽  
Christelle Reynes ◽  
Adam M. Brickman ◽  
Frank A. Provenzano ◽  
Jordan Muraskin ◽  
...  
Keyword(s):  
Spatial Distribution ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
White Matter Lesions ◽  
Cerebral White Matter ◽  
Cerebral White Matter Lesions
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