scholarly journals Spatial Distribution of Cerebral White Matter Lesions Predicts Progression to Mild Cognitive Impairment and Dementia

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e56972 ◽  
Author(s):  
Marion Mortamais ◽  
Christelle Reynes ◽  
Adam M. Brickman ◽  
Frank A. Provenzano ◽  
Jordan Muraskin ◽  
...  
Keyword(s):  
Spatial Distribution ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
White Matter Lesions ◽  
Cerebral White Matter ◽  
Cerebral White Matter Lesions

scholarly journals Do cerebral white matter lesions influence the rate of progression from mild cognitive impairment to dementia?

2012 ◽  
Vol 25 (1) ◽  
pp. 120-127 ◽  
Author(s):  
Michael E. Devine ◽  
J. Andres Saez Fonseca ◽  
Zuzana Walker
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
White Matter Lesions ◽  
Cerebral White Matter ◽  
Brain Scans ◽  
Mri Brain ◽  
Cerebral White Matter Lesions ◽  
Ct And Mri

ABSTRACTBackground: Cerebral white matter lesions (WML), evident on CT and MRI brain scans, are histopathologically heterogeneous but associated with vascular risk factors and thought mainly to indicate ischemic damage. There has been disagreement over their clinical prognostic value in predicting conversion from mild cognitive impairment (MCI) to dementia.Methods: We scrutinised and rated CT and MRI brain scans for degree of WML in a memory clinic cohort of 129 patients with at least 1 year of follow-up. We examined the relationship between WML severity and time until conversion to dementia for all MCI patients and for amnestic (aMCI) and non-amnestic (naMCI) subgroups separately.Results: Five-year outcome data were available for 87 (67%) of the 129 patients. The proportion of patients converting to dementia was 25% at 1 year and 76% at 5 years. Patients with aMCI converted to dementia significantly earlier than those with naMCI. WML severity was not associated with time to conversion to dementia for either MCI patients in general or aMCI patients in particular. Among naMCI patients, there was a tendency for those with a low degree of WML to survive without dementia for longer than those with a high degree of WML. However, this was not statistically significant.Conclusions: MCI subtype is a significant independent predictor of conversion to dementia, with aMCI patients having higher risk than naMCI for conversion throughout the 5-year follow-up period. WML severity does not influence conversion to dementia for aMCI but might accelerate progression in naMCI.

scholarly journals White Matter Lesions and Cognitive Impairment as Silent Cerebral Disease in Hypertension

2006 ◽  
Vol 6 ◽  
pp. 494-501 ◽  
Author(s):  
Cristina Sierra ◽  
Antonio Coca
Keyword(s):  
Blood Pressure ◽  
Cognitive Impairment ◽  
White Matter ◽  
Indirect Evidence ◽  
White Matter Lesions ◽  
Cerebral White Matter ◽  
Cognitive Changes ◽  
Cerebral Disease ◽  
Functional Changes ◽  
Cerebral White Matter Lesions

Although the pathogenesis and clinical significance of cerebral white matter lesions remain controversial, it is well established that age and hypertension are the most important factors related to the presence of these lesions. Hypertension is known to be the most important factor for developing stroke and vascular dementia. In addition, the presence of cerebral white matter lesions is an important prognostic factor for the development of stroke, and also for cognitive impairment and dementia. The mechanisms underlying hypertension-related cognitive changes are complex and are not yet fully understood. Correlations between cerebral white matter lesions and elevated blood pressure provide indirect evidence that structural and functional changes in the brain over time may lead to lowered cognitive functioning when blood pressure control is poor or lacking.Some authors have suggested that the presence of white matter lesions in hypertensive patients could be considered an early marker of brain damage.

Increased adiponectin is associated with cerebral white matter lesions in the elderly with cognitive impairment

2018 ◽  
Vol 33 (4) ◽  
pp. 1385-1388 ◽  
Author(s):  
Youshi Fujita ◽  
Takashi Toyomoto ◽  
Tomomi Sakoh-Goshima ◽  
Yutaka Kohno ◽  
Masafumi Okada ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
White Matter ◽  
White Matter Lesions ◽  
The Elderly ◽  
Cerebral White Matter ◽  
Cerebral White Matter Lesions

scholarly journals Cerebral White Matter Lesions, Gait, and the Risk of Incident Falls

Stroke ◽  
2009 ◽  
Vol 40 (1) ◽  
pp. 175-180 ◽  
Author(s):  
Velandai Srikanth ◽  
Richard Beare ◽  
Leigh Blizzard ◽  
Thanh Phan ◽  
Jennifer Stapleton ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Lesions ◽  
Cerebral White Matter ◽  
Cerebral White Matter Lesions
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