Quality of evidence in drug compendia supporting off-label use of typical and atypical antipsychotic medications

2012 ◽  
Vol 24 (3) ◽  
pp. 137-146 ◽  
Author(s):  
Richard P. Paczynski ◽  
G. Caleb Alexander ◽  
Vernon M. Chinchilli ◽  
Stefan P. Kruszewski
Keyword(s):  
Atypical Antipsychotic ◽  
Off Label Use ◽  
Antipsychotic Medications ◽  
Quality Of Evidence ◽  
Off Label ◽  
Atypical Antipsychotic Medications ◽  
Label Use

scholarly journals Increasing off-label use of antipsychotic medications in the United States, 1995-2008

2011 ◽  
Vol 20 (2) ◽  
pp. 177-184 ◽  
Author(s):  
G. C. Alexander ◽  
S. A. Gallagher ◽  
A. Mascola ◽  
R. M. Moloney ◽  
R. S. Stafford
Keyword(s):  
United States ◽  
The United States ◽  
Off Label Use ◽  
Antipsychotic Medications ◽  
Off Label ◽  
Label Use

Off-Label Use of Antidepressant, Anticonvulsant, and Antipsychotic Medications Among Georgia Medicaid Enrollees in 2001

2006 ◽  
Vol 67 (06) ◽  
pp. 972-982 ◽  
Author(s):  
Hua Chen ◽  
Jaxk H. Reeves ◽  
Jack E. Fincham ◽  
William K. Kennedy ◽  
Jeffrey H. Dorfman ◽  
...  
Keyword(s):  
Off Label Use ◽  
Antipsychotic Medications ◽  
Off Label ◽  
Label Use

scholarly journals Benefits of Switching from Typical to Atypical Antipsychotic Medications: A Longitudinal Study in a Community-Based Setting

2002 ◽  
Vol 47 (9) ◽  
pp. 870-874 ◽  
Author(s):  
Peter E Cook ◽  
Joel O Goldberg ◽  
Ryan J Van Lieshout
Keyword(s):  
Quality Of Life ◽  
Atypical Antipsychotic ◽  
Negative Symptoms ◽  
Mental Health Program ◽  
Community Support ◽  
Antipsychotic Medications ◽  
Crisis Services ◽  
Utilization Data ◽  
Atypical Antipsychotic Medications

Objective: This study examines the clinical and resource utilization effects of switching stable outpatients with schizophrenia from a typical to an atypical antipsychotic medication. Method: We monitored 43 schizophrenia patients from a community mental health program who tolerated switching from typical to atypical antipsychotic medications. We used the Positive and Negative Syndrome Scale (PANSS), Lehman Quality of Life Interview (QOL), and service utilization data for 2 years before and 2 years after the switch. Results: The switch to atypical antipsychotics was associated with significant improvements in positive symptoms, in general psychopathology, and in quality of life. Resource requirements, including case-management and crisis services and hospitalization days, were significantly reduced. We observed no changes in the sample's already low levels of negative symptoms. Conclusions: In stable outpatients with schizophrenia in a real-world setting, switching to an atypical antipsychotic can result in sustained, significant improvement in clinical response and quality of life, as well as in reduced need for hospitalization and community support,.

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